Propagation modes and source locations of the auroral kilometric radiation (AKR) identified by using the wave distribution function method

The propagation characteristics of Auroral Kilometric Radiation (AKR), the propagation mode, power flux as well as propagation direction, have been analyzed by applying the wave distribution function method to the Poynting Flux measurement data obtained by the PWS system onboard the Akebono (EXOS-D) satellite. The results revealed that the power flux of O-mode waves was about 10 percent of the X-mode wave intensity in strong AKR emissions. The X-mode AKR waves tend to fill inside the radiation cone of an auroral field line. On the other hand, O-mode AKR showed two different propagation directions, one was directed to almost 90° with respect to the local magnetic field and the other showed angle in the vicinity of 40°. It was shown that the source locations of O-mode AKR waves with the propagation angle of about 40° located close to the source of the intense X-mode AKR waves

Eucalyptus Leaf Extract Suppresses the Postprandial Elevation of Portal, Cardiac and Peripheral Fructose Concentrations after Sucrose Ingestion in Rats

Overintake of sucrose or fructose induces adiposity. Fructose undergoes a strong Maillard reaction, which worsens diabetic complications. To determine whether Eucalyptus globulus leaf extract (ELE) suppresses the postprandial elevation of serum fructose concentrations (SFCs) in the portal, cardiac, and peripheral blood after sucrose ingestion, we performed gas chromatography/mass spectrometry (GC/MS) and measured SFC without any interference by contaminating glucose in the samples. Fasting Wistar rats were orally administered water (control group) or ELE (ELE group) before sucrose ingestion. Blood was collected from the portal vein, heart, and tail. The increase in the SFCs in the portal and cardiac samples 30 min after sucrose ingestion was lower in the ELE group than in the control group. The coefficient of correlation between the SFCs in the portal and cardiac samples was 0.825. The peripheral SFC in the control group progressively increased and was 146 µmol/L at 60 min. This increase was significantly lower in the ELE group. In contrast, the serum glucose concentrations in the 2 groups were similar. ELE suppressed postprandial hyperfructosemia in the portal, cardiac, and peripheral circulations. ELE may counteract glycation caused by high blood fructose concentrations induced by the consumption of fructose-containing foods or drinks

Dynamical Generation of Fermion Mass and Magnetic Field in Three-Dimensional QED with Chern-Simons Term

We study dynamical symmetry breaking in three-dimensional QED with a Chern-Simons (CS) term, considering the screening effect of $N$ flavor fermions. We find a new phase of the vacuum, in which both the fermion mass and a magnetic field are dynamically generated, when the coefficient of the CS term $\kappa$ equals $N e^2/4 \pi$. The resultant vacuum becomes the finite-density state half-filled by fermions. For $\kappa=N e^2/2 \pi$, we find the fermion remains massless and only the magnetic field is induced. For $\kappa=0$, spontaneous magnetization does not occur and should be regarded as an external field.Comment: 8 pages, no figure, to be published in Phys. Rev. Let

Magnetization and dynamically induced finite densities in three-dimensional Chern-Simons QED

In (2+1)-dimensional QED with a Chern-Simons term, we show that spontaneous magnetization occurs in the context of finite density vacua, which are the lowest Landau levels fully or half occupied by fermions. Charge condensation is shown to appear so as to complement the fermion anti-fermion condensate, which breaks the flavor U(2N) symmetry and causes fermion mass generation. The solutions to the Schwinger-Dyson gap equation show that the fermion self-energy contributes to the induction of a finite fermion density and/or fermion mass. The magnetization can be supported by charge condensation for theories with the Chern-Simons coefficient $\kappa=N e^2/2 \pi$, and $\kappa=N e^2/4 \pi$, under the Gauss law constraint. For $\kappa=N e^2/4 \pi$, both the magnetic field and the fermion mass are simultaneously generated in the half-filled ground state, which breaks the U(2N) symmetry as well as the Lorentz symmetry.Comment: 47 pages, 5 figures, revtex; revised for publication in Nucl. Phys. B, added some references in section 1 and corrected typo

Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation

The aim of the present study is to clarify the functional expression and physiological role in brain neurons of carnitine/organic cation transporter OCTN1/SLC22A4, which accepts the naturally occurring antioxidant ergothioneine (ERGO) as a substrate in vivo. After intracerebroventricular administration, the distribution of [ 3H]ERGO in several brain regions of octn1 -/- mice was much lower than that in wild-type mice, whereas extracellular marker [ 14C]mannitol exhibited similar distribution in the two strains. The [ 3H]ERGO distribution in wild-type mice was well correlated with the amount of ERGO derived from food intake and the OCTN1 mRNA level in each brain region. Immunohistochemical analysis revealed colocalization of OCTN1 with neuronal cell markers microtubule-associated protein 2 (MAP2) and βIII-tubulin in mouse brain and primary cultured cortical neurons, respectively. Moreover, cultured cortical neurons exhibited time-dependent and saturable uptake of [ 3H]ERGO. These results demonstrate that OCTN1 is functionally expressed in brain neurons. The addition of ERGO simultaneously with serum to culture medium of cortical neurons attenuated mRNA and protein expressions of MAP2, βIII-tubulin and synapse formation marker synapsin I, and induced those of sex determining region Y-box 2 (Sox2), which is required to maintain the properties of undifferentiated neural stem cells. In neuronal model Neuro2a cells, knockdown of OCTN1 by siRNA reduced the uptake of [ 3H]ERGO with concomitant up-regulation of oxidative stress marker HO-1 and Sox2, and down-regulation of neurite outgrowth marker GAP43. Interestingly, the siRNA knockdown decreased the number of differentiated Neuro2a cells showing long neurites, but increased the total number of cells. Thus, OCTN1 is involved in cellular differentiation, but inhibits their proliferation, possibly via the regulation of cellular oxidative stress. This is the first evidence that OCTN1 plays a role in neuronal differentiation and proliferation, which are required for brain development. Crown Copyright © 2012

Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons.

The aim of the present study is to clarify the functional expression and physiological role in neural progenitor cells (NPCs) of carnitine/organic cation transporter OCTN1/SLC22A4, which accepts the naturally occurring food-derived antioxidant ergothioneine (ERGO) as a substrate in vivo. Real-time PCR analysis revealed that mRNA expression of OCTN1 was much higher than that of other organic cation transporters in mouse cultured cortical NPCs. Immunocytochemical analysis showed colocalization of OCTN1 with the NPC marker nestin in cultured NPCs and mouse embryonic carcinoma P19 cells differentiated into neural progenitor-like cells (P19-NPCs). These cells exhibited time-dependent [(3)H]ERGO uptake. These results demonstrate that OCTN1 is functionally expressed in murine NPCs. Cultured NPCs and P19-NPCs formed neurospheres from clusters of proliferating cells in a culture time-dependent manner. Exposure of cultured NPCs to ERGO or other antioxidants (edaravone and ascorbic acid) led to a significant decrease in the area of neurospheres with concomitant elimination of intracellular reactive oxygen species. Transfection of P19-NPCs with small interfering RNA for OCTN1 markedly promoted formation of neurospheres with a concomitant decrease of [(3)H]ERGO uptake. On the other hand, exposure of cultured NPCs to ERGO markedly increased the number of cells immunoreactive for the neuronal marker βIII-tubulin, but decreased the number immunoreactive for the astroglial marker glial fibrillary acidic protein (GFAP), with concomitant up-regulation of neuronal differentiation activator gene Math1. Interestingly, edaravone and ascorbic acid did not affect such differentiation of NPCs, in contrast to the case of proliferation. Knockdown of OCTN1 increased the number of cells immunoreactive for GFAP, but decreased the number immunoreactive for βIII-tubulin, with concomitant down-regulation of Math1 in P19-NPCs. Thus, OCTN1-mediated uptake of ERGO in NPCs inhibits cellular proliferation via regulation of oxidative stress, and also promotes cellular differentiation by modulating the expression of basic helix-loop-helix transcription factors via an unidentified mechanism different from antioxidant action