Making Tracks: The Case for Building a 21st Century Transportation Network in Maryland

Outlines how investing in public transit by building a regional rail system, expanding or linking rail and bus lines, and improving transit in smaller towns would reduce traffic, oil dependency, and global warming as well as create healthier communities

Joint inversion estimate of regional glacial isostatic adjustment in Antarctica considering a lateral varying Earth structure (ESA STSE Project REGINA)

A major uncertainty in determining the mass balance of the Antarctic ice sheet from measurements of satellite gravimetry, and to a lesser extent satellite altimetry, is the poorly known correction for the ongoing deformation of the solid Earth caused by glacial isostatic adjustment (GIA). Although much progress has been made in consistently modelling the ice-sheet evolution throughout the last glacial cycle, as well as the induced bedrock deformation caused by these load changes, forward models of GIA remain ambiguous due to the lack of observational constraints on the ice sheet's past extent and thickness and mantle rheology beneath the continent. As an alternative to forward modelling GIA, we estimate GIA from multiple space-geodetic observations: GRACE, Envisat/ICESat and GPS. Making use of the different sensitivities of the respective satellite observations to current and past surface mass (ice mass) change and solid Earth processes, we estimate GIA based on viscoelastic response functions to disc load forcing. We calculate and distribute the viscoelastic response functions according to estimates of the variability of lithosphere thickness and mantle viscosity in Antarctica. We compare our GIA estimate with published GIA corrections and evaluate its impact in determining the ice mass balance in Antarctica from GRACE and satellite altimetry. Particular focus is applied to the Amundsen Sea Sector in West Antarctica, where uplift rates of several cm/yr have been measured by GPS. We show that most of this uplift is caused by the rapid viscoelastic response to recent ice-load changes, enabled by the presence of a low-viscosity upper mantle in West Antarctica. This paper presents the second and final contribution summarizing the work carried out within a European Space Agency funded study, REGINA, (www.regina-science.eu)

Cancer vaccines with emphasis on a viral oncolysate melanoma vaccine

Biotherapy of malignant diseases has become the fourth treatment modality besides surgery, chemo- and radiotherapy. Whole cell melanoma vaccines with or without BCG and other adjuvants, purified ganglioside and shed antigens, recombinant viruses carrying tumor antigens, dendritic cells pulsed with antigenic peptides etc. are in clinical trials.Efficacious viral oncolysate vaccines induce the host to mount tumor-specific cytotoxic T-cell response and prevention of relapses is supported by clinical trials. The use of „polyvalent” whole cell vaccines vs. purified or genetically engineered single antigen vaccines is justified asi.only very few single tumor antigens are present in all tumors of a given histological type; andii.antigen modulation occurs in tumors rendering them resistant to immune attack generated by vaccine against a single antigen. Thus polyvalent vaccines immunize against several antigens vs. against a selected antigen

Motivation as a predictor of outcomes in school-based humanistic counselling

Recent years have seen a growth in the provision of counselling within UK secondary schools, and research indicates that it is associated with significant reductions in psychological distress. However, little is known about the moderators and mediators of positive therapeutic benefit. In the field of adult mental health, motivation has been found to be one of the strongest predictors of therapeutic outcomes, and it was hypothesised that this may also be a predictor of outcomes for young people in school-based counselling services. To assess the relationship between young people’s motivation for counselling and its effectiveness within a secondary school setting. Eighty-one young people (12 - 17 years old) who attended school-based humanistic counselling services in Scotland. Clients completed a measure of motivation for counselling at the commencement of their therapeutic work and a measure of psychological wellbeing at the commencement and termination of counselling. Motivation for counselling was not found to be significantly related to outcomes. The results indicate that the association between motivation and outcomes may be weaker in young people as compared with adults. However, a number of design factors may also account for the non-significant findings: insufficient participants, marginal reliability of the motivation measure and social desirability effects

Increasing Depression Screening and Treatment

Aims for Improvement Increase response to depression advisory in EHR from 39% (January 2021) to 60% or greater (March 2021) Increase referrals to behavioral health from baseline of 39/month (January 2021) by 25% (March 2021

High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells.

Progenitor human nasal epithelial cells (hNECs) are an essential cell source for the reconstruction of the respiratory pseudostratified columnar epithelium composed of multiple cell types in the context of infection studies and disease modeling. Hitherto, manual seeding has been the dominant method for creating nasal epithelial tissue models through biofabrication. However, this approach has limitations in terms of achieving the intricate three-dimensional (3D) structure of the natural nasal epithelium. 3D bioprinting has been utilized to reconstruct various epithelial tissue models, such as cutaneous, intestinal, alveolar, and bronchial epithelium, but there has been no attempt to use of 3D bioprinting technologies for reconstruction of the nasal epithelium. In this study, for the first time, we demonstrate the reconstruction of the nasal epithelium with the use of primary hNECs deposited on Transwell inserts via droplet-based bioprinting (DBB), which enabled high-throughput fabrication of the nasal epithelium in Transwell inserts of 24-well plates. DBB of progenitor hNECs ranging from one-tenth to one-half of the cell seeding density employed during the conventional cell seeding approach enabled a high degree of differentiation with the presence of cilia and tight-junctions over a 4 weeks air-liquid interface culture. Single cell RNA sequencing of these cultures identified five major epithelial cells populations, including basal, suprabasal, goblet, club, and ciliated cells. These cultures recapitulated the pseudostratified columnar epithelial architecture present in the native nasal epithelium and were permissive to respiratory virus infection. These results denote the potential of 3D bioprinting for high-throughput fabrication of nasal epithelial tissue models not only for infection studies but also for other purposes, such as disease modeling, immunological studies, and drug screening

GW4 Bridging the Gap

Bridging the Gap identified that realising the full benefits of Arts and Humanities research collaborations requires deeper consideration of research relationships as processes rather than just a means to an end. A processual approach demonstrates the potential role of Arts and Humanities research collaborations within a dynamic regional creative and cultural ecosystem can achieve a number of successes

Redes sociais, aplicativos e vídeos para pessoas com estomia intestinal, traqueostomia e cuidadores: das redes informais para as comunidades de prática

This article seeks to describe the evidence on social networks as informal online networks aimed at people with tracheostomy, intestinal ostomy and their caregivers, providing evidence of how online Communities of Practice (CPo) could use social networks, supported self-care apps and videos. An integrative review was carried out in all six stages, with a timeline search between 2010 and 2021 in the LILACS, PUBMED, CINAHL, SCOPUS and Web of Science databases. After analyzing 314 articles, the 17 articles included in the sample were explored in 4 categories, still using the framework of the social scientist Étienne Wenger, who coined the term CPo. Thus, there were only informal networks and not communities of practice, nor synchronous use of technological resources in them, so community patterns were sought in existing informal networks, considering the benefits generated for people with ostomy and caregivers when accessing videos, applications and software from future communities of practice. Finally, the seven principles to cultivate them for the profile studied are exposed, relying on the existing informal networks and a research agenda around this unexplored nationally and internationally.Este artigo busca descrever as evidências sobre redes sociais como redes informais online destinadas a pessoas com traqueostomia, estomia intestinal e seus cuidadores, lançando evidências de como Comunidades de Prática on-line (CPo) poderiam usar redes sociais, aplicativos de autocuidado apoiado e vídeos. Efetuou-se revisão integrativa na totalidade de seis etapas, com busca em linha temporal entre 2010 e 2021 nas bases LILACS, PUBMED, CINAHL, SCOPUS e Web of Science. Após análise de 314 artigos, os 17 artigos inclusos para a amostra foram explorados em 4 categorias empregando ainda o referencial do cientista social Étienne Wenger que cunhou o termo CPo. Destarte, verificaram-se apenas redes informais e não comunidades de prática, tampouco uso síncrono dos recursos tecnológicos nas mesmas, portanto buscaram-se padrões de comunidades nas redes informais existentes ponderando ainda os benefícios gerados as pessoas com estomia e cuidadores ao acessarem vídeos, aplicativos e softwares a partir de futuras comunidades de prática. Por fim, expõem-se os sete princípios para cultivá-las para o perfil estudado contando com as redes informais já existentes e uma agenda de pesquisa em torno deste recorte inexplorado nacionalmente e internacionalmente

Redes sociais, aplicativos e vídeos para pessoas com estomia intestinal, traqueostomia e cuidadores: das redes informais para as comunidades de prática

This article seeks to describe the evidence on social networks as informal online networks aimed at people with tracheostomy, intestinal ostomy and their caregivers, providing evidence of how online Communities of Practice (CPo) could use social networks, supported self-care apps and videos. An integrative review was carried out in all six stages, with a timeline search between 2010 and 2021 in the LILACS, PUBMED, CINAHL, SCOPUS and Web of Science databases. After analyzing 314 articles, the 17 articles included in the sample were explored in 4 categories, still using the framework of the social scientist Étienne Wenger, who coined the term CPo. Thus, there were only informal networks and not communities of practice, nor synchronous use of technological resources in them, so community patterns were sought in existing informal networks, considering the benefits generated for people with ostomy and caregivers when accessing videos, applications and software from future communities of practice. Finally, the seven principles to cultivate them for the profile studied are exposed, relying on the existing informal networks and a research agenda around this unexplored nationally and internationally.Este artigo busca descrever as evidências sobre redes sociais como redes informais online destinadas a pessoas com traqueostomia, estomia intestinal e seus cuidadores, lançando evidências de como Comunidades de Prática on-line (CPo) poderiam usar redes sociais, aplicativos de autocuidado apoiado e vídeos. Efetuou-se revisão integrativa na totalidade de seis etapas, com busca em linha temporal entre 2010 e 2021 nas bases LILACS, PUBMED, CINAHL, SCOPUS e Web of Science. Após análise de 314 artigos, os 17 artigos inclusos para a amostra foram explorados em 4 categorias empregando ainda o referencial do cientista social Étienne Wenger que cunhou o termo CPo. Destarte, verificaram-se apenas redes informais e não comunidades de prática, tampouco uso síncrono dos recursos tecnológicos nas mesmas, portanto buscaram-se padrões de comunidades nas redes informais existentes ponderando ainda os benefícios gerados as pessoas com estomia e cuidadores ao acessarem vídeos, aplicativos e softwares a partir de futuras comunidades de prática. Por fim, expõem-se os sete princípios para cultivá-las para o perfil estudado contando com as redes informais já existentes e uma agenda de pesquisa em torno deste recorte inexplorado nacionalmente e internacionalmente

Can aliphatic anchoring groups be utilised with dyes for p-type dye sensitized solar cells?

A series of novel laterally anchoring tetrahydroquinoline derivatives have been synthesized and investigated for their use in NiO-based p-type dye-sensitized solar cells. The kinetics of charge injection and recombination at the NiO-dye interface for these dyes have been thoroughly investigated using picosecond transient absorption and time-resolved infrared measurements. It was revealed that despite the anchoring unit being electronically decoupled from the dye structure, charge injection occurred on a sub picosecond timescale. However, rapid recombination was also observed due to the close proximity of the electron acceptor on the dyes to the NiO surface, ultimately limiting the performance of the p-DSCs