Supporting Professional Psychological Services and Research in Kyrgyzstan: A Collaboration with the Open Society Foundation & the Psychology Department of American University of Central Asia

This partnership between the Psychology Department of American University of Central Asia (AUCA), Bishkek, Kyrgyzstan, and the Department of Counseling and School Psychology began in 2005 through an Academic Fellowship program that provides support for Returning Scholars to their home countries. Dr. Sharon Horne of the Department of Counseling and School Psychology has been working closely with the department for nearly a decade, focusing research and teaching mentorship of junior faculty and students; engaged research; and the development of a professional psychology community. Working with 7 Returning Scholars and other colleagues at AUCA, their partnership has produced publications as well as joint presentations at many international conferences, and fostered student exchanges

Partnership & Participation : The Pearls, Pitfalls and Pinnacles

Explore how four agencies developed a formula for working in partnership to facilitate a dialogue between children and young people and decision makers

Dynamical modeling of the C iv broad line region of the z=2.805 multiply imaged quasar SDSS J2222+2745

P.W. and T.T. gratefully acknowledge support by the National Science Foundation through grant AST-1907208 "Collaborative Research: Establishing the foundations of black hole mass measurements of AGN across cosmic time" and by the Packard Foundation through a Packard Research Fellowship to T.T. Research at UC Irvine was supported by NSF grant AST-1907290. K.H. acknowledges support from STFC grant ST/R000824/1.We present the first ever models of a broad line region (BLR) at the peak of active galactic nucleus (AGN) activity using the multiply imaged z = 2.805 quasar SDSS J2222+2745. The modeled data consist of monthly spectra covering the broad C IV emission line over a 5.3 yr baseline. The models suggest a thick disk BLR that is inclined by degrees 40 degrees to the observer's line of sight and with an emissivity weighted median radius of = rmedian = 33.0(-2.1)(+2.44) light days. The kinematics are dominated by near-circular Keplerian motion with the remainder inflowing. The restframe lag one would measure from the models is taumedian = 36.4(-1.8)(+1.8) days, which is consistent with measurements based on cross-correlation. We show a possible geometry and transfer function based on the model fits and find that the model-produced velocity-resolved lags are consistent with those from cross-correlation. We measure a black hole mass of log10(MBH/M⊙) = 8.31(-0.06)(+0.07), which requires a scale factor of log10 (fmean,σ) = 0.20(-0.07)(+0.09.). This is the most precise MBH measurement for any AGN at cosmological distances and it demonstrates that the precision required for BH-host coevolution studies is attainable.PostprintPeer reviewe

Site-Selective Aliphatic C–H Chlorination Using N -Chloroamides Enables a Synthesis of Chlorolissoclimide

Methods for the practical, intermolecular functionalization of aliphatic C-H bonds remain a paramount goal of organic synthesis. Free radical alkane chlorination is an important industrial process for the production of small molecule chloroalkanes from simple hydrocarbons, yet applications to fine chemical synthesis are rare. Herein, we report a site-selective chlorination of aliphatic C-H bonds using readily available N-chloroamides and apply this transformation to a synthesis of chlorolissoclimide, a potently cytotoxic labdane diterpenoid. These reactions deliver alkyl chlorides in useful chemical yields with substrate as the limiting reagent. Notably, this approach tolerates substrate unsaturation that normally poses major challenges in chemoselective, aliphatic C-H functionalization. The sterically and electronically dictated site selectivities of the C-H chlorination are among the most selective alkane functionalizations known, providing a unique tool for chemical synthesis. The short synthesis of chlorolissoclimide features a high yielding, gram-scale radical C-H chlorination of sclareolide and a three-step/two-pot process for the introduction of the β-hydroxysuccinimide that is salient to all the lissoclimides and haterumaimides. Preliminary assays indicate that chlorolissoclimide and analogues are moderately active against aggressive melanoma and prostate cancer cell lines

Prospectus, November 18, 1975

PC NEWS IN BRIEF: TOYS FOR TOTS, SHOPPING TRIP, KARATE, LOU HENSON, CHEERLEADERS, BIO 200; Hurry, 3 days remain; IKE…What?; Off Campus offering; P.C. Women 4th in State; editorial; Roots & Radicals; Far Out Planet; Letter To The Editor; Student Achievement Recognition Award; Some - Dancers?; Stick it in your...; P.M. Student Coffee Hour; Tickets Available; Aides to host tea For C-U Teachers; Introducing, Wes Crum; Distaff Side; \u27Why can\u27t we be friends?\u27; Dog Wash; EA to meet; First Meeting; Photo Contest; ERA Rally Held; (IBEA) Meeting Held; Good News; Louisiana Funk at its greatest; Purlie; Furor shakes up Stu-Go; Cited for misconduct: Three members suspended; Discord within Stu-Go: Conference under fire; Finance Board not doing job; Alternatives to Stu-Go; McMullen Resigns; Gameroom Brings Big money; Broken Record?; StuGo States Pinball Project Progresses; Skylines: Black holes?; Parkland Events; Students Not Fascists; Vinyl Love; B and O preforms; Country Bouquet: The Grand Ole Opry ; Dear Bonnie; Classified; Moondogs demolish Wrecks; Fast Freddy\u27s football forecast; I.M. Basketball starts today; Basketball schedule; Games of November 22; Coach\u27s Corner; Parkland Athletes Earn International Acclaim; Karate Demo set for Nov. 20; Ken needs you; Sports Views; Blackhawks vs Broadstreet Bullies at Chicago Stadiumhttps://spark.parkland.edu/prospectus_1975/1002/thumbnail.jp

The Molecular Biogeography of the Indo-Pacific: Testing Hypotheses With Multispecies Genetic Patterns

Aim: To test hypothesized biogeographic partitions of the tropical Indo-Pacific Ocean with phylogeographic data from 56 taxa, and to evaluate the strength and nature of barriers emerging from this test. \u3eLocation: The Indo-Pacific Ocean. Time Period: Pliocene through the Holocene. Major Taxa Studied: Fifty-six marine species. Methods: We tested eight biogeographic hypotheses for partitioning of the Indo-Pacific using a novel modification to analysis of molecular variance. Putative barriers to gene flow emerging from this analysis were evaluated for pairwise ΦST, and these ΦST distributions were compared to distributions from randomized datasets and simple coalescent simulations of vicariance arising from the Last Glacial Maximum. We then weighed the relative contribution of distance versus environmental or geographic barriers to pairwise ΦST with a distance-based redundancy analysis (dbRDA). Results: We observed a diversity of outcomes, although the majority of species fit a few broad biogeographic regions. Repeated coalescent simulation of a simple vicariance model yielded a wide distribution of pairwise ΦST that was very similar to empirical distributions observed across five putative barriers to gene flow. Three of these barriers had median ΦST that were significantly larger than random expectation. Only 21 of 52 species analysed with dbRDA rejected the null model. Among these, 15 had overwater distance as a significant predictor of pairwise ΦST, while 11 were significant for geographic or environmental barriers other than distance. Main Conclusions: Although there is support for three previously described barriers, phylogeographic discordance in the Indo-Pacific Ocean indicates incongruity between processes shaping the distributions of diversity at the species and population levels. Among the many possible causes of this incongruity, genetic drift provides the most compelling explanation: given massive effective population sizes of Indo-Pacific species, even hard vicariance for tens of thousands of years can yield ΦST values that range from 0 to nearly 0.5

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study

Background: Lipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary heart disease remains less clear. Methods: We obtained data from 3313 patients with established coronary heart disease in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy. Results for plasma lipoprotein(a) concentrations were validated in five independent studies involving 10 195 patients with established coronary heart disease. Results for genetic associations were replicated through large-scale collaborative analysis in the GENIUS-CHD consortium, comprising 106 353 patients with established coronary heart disease and 19 332 deaths in 22 studies or cohorts. Findings: The median follow-up was 9·9 years. Increased severity of coronary heart disease was associated with lipoprotein(a) concentrations in plasma in the highest tertile (adjusted hazard radio [HR] 1·44, 95% CI 1·14–1·83) and the presence of either LPA SNP (1·88, 1·40–2·53). No associations were found in LURIC with all-cause mortality (highest tertile of lipoprotein(a) concentration in plasma 0·95, 0·81–1·11 and either LPA SNP 1·10, 0·92–1·31) or cardiovascular mortality (0·99, 0·81–1·2 and 1·13, 0·90–1·40, respectively) or in the validation studies. Interpretation: In patients with prevalent coronary heart disease, lipoprotein(a) concentrations and genetic variants showed no associations with mortality. We conclude that these variables are not useful risk factors to measure to predict progression to death after coronary heart disease is established. Funding: Seventh Framework Programme for Research and Technical Development (AtheroRemo and RiskyCAD), INTERREG IV Oberrhein Programme, Deutsche Nierenstiftung, Else-Kroener Fresenius Foundation, Deutsche Stiftung für Herzforschung, Deutsche Forschungsgemeinschaft, Saarland University, German Federal Ministry of Education and Research, Willy Robert Pitzer Foundation, and Waldburg-Zeil Clinics Isny