Associative analysis of spatial learning in environments with a distinctive shape

The aim of this thesis was to evaluate the proposal by Miller and Shettleworth (2007) that learning about geometric cues in environments with a distinctive shape is governed by a competitive learning rule (e.g., Rescorla & Wagner, 1972). To do this, in all experiments, rats were trained to locate a hidden platform by reference to the shape of a swimming pool. Chapter 2 (Experiments 1 -4) assessed whether a landmark suspended above the platform would overshadow learning about geometric cues. No overshadowing was recorded, even when the salience of the geometric cues was reduced. These findings are inconsistent with the model of Miller and Shettleworth (2007). In Chapter 3 (Experiments 5-7), a blocking paradigm was used. When rats were given extended pre-training with a landmark above the platform, only then did the landmark successfully block learning about geometric cues. However, some unexpected findings suggested that perhaps the spatial cues were competing for attention rather than associative strength. The experiments in Chapter 4 (Experiments 8 and 9) successfully demonstrated superconditioning of geometric cues by an inhibitory landmark providing convincing evidence that learning about geometric cues is governed by the principles of associative learning. Miller and ShettlewortiVs (2007) model however, failed to predict this outcome. Experiments 10-13 in Chapters 5 and 6 showed that associations formed between geometric and non-geometric cues. This outcome provides the basis for a viable explanation for potentiation and for the past failures to find cue competition in the spatial domain. The empirical findings of this thesis show that learning about geometric cues is not entirely void of associative processes as once thought. A number of recent models of spatial learning are discussed.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Associative analysis of spatial learning in environments with a distinctive shape.

The aim of this thesis was to evaluate the proposal by Miller and Shettleworth (2007) that learning about geometric cues in environments with a distinctive shape is governed by a competitive learning rule (e.g., Rescorla & Wagner, 1972). To do this, in all experiments, rats were trained to locate a hidden platform by reference to the shape of a swimming pool. Chapter 2 (Experiments 1 -4) assessed whether a landmark suspended above the platform would overshadow learning about geometric cues. No overshadowing was recorded, even when the salience of the geometric cues was reduced. These findings are inconsistent with the model of Miller and Shettleworth (2007). In Chapter 3 (Experiments 5-7), a blocking paradigm was used. When rats were given extended pre-training with a landmark above the platform, only then did the landmark successfully block learning about geometric cues. However, some unexpected findings suggested that perhaps the spatial cues were competing for attention rather than associative strength. The experiments in Chapter 4 (Experiments 8 and 9) successfully demonstrated superconditioning of geometric cues by an inhibitory landmark providing convincing evidence that learning about geometric cues is governed by the principles of associative learning. Miller and ShettlewortiVs (2007) model however, failed to predict this outcome. Experiments 10-13 in Chapters 5 and 6 showed that associations formed between geometric and non-geometric cues. This outcome provides the basis for a viable explanation for potentiation and for the past failures to find cue competition in the spatial domain. The empirical findings of this thesis show that learning about geometric cues is not entirely void of associative processes as once thought. A number of recent models of spatial learning are discussed

The effect of schizotypy on spatial learning in an environment with a distinctive shape

In two experiments, participants completed the Oxford-Liverpool Inventory of Feelings and Experiences measuring schizotypal traits across four dimensions (unusual experiences, cognitive disorganization, introvertive anhedonia, and impulsive non-conformity). They then took part in a virtual navigation task where they were required to learn about the position of a hidden goal with reference to geometric cues of a rectangular arena or rely on colored wall panels to find the hidden goal in a square-shaped arena. Unusual experience and cognitive disorganization were significant predictors of the use of geometric cues, but no significant predictors were found for the use of wall panels. Implications to hippocampal function and the clinical domain are considered

VPMS J1342+2840 - an unusual quasar from the variability and proper motion survey

We report the discovery of the highly peculiar, radio-loud quasar VPMS J1342+2840 (z ~ 1.3) from the variability and proper motion survey. We present spectroscopic, imaging and photometric observations. The unusual spectrum shows a strong depression of the continuum over a wide wavelength range in the blue part without the typical structures of broad absorption line (BAL) troughs. The image of the quasar is unresolved and there is no evidence for a foreground object on the line of sight. The broad-band spectral energy distribution is not consistent with obvious dust reddening with the standard SMC extinction curve. The downturn of the continuum flux of VPMS J1342+2840 at short wavelengths can be caused by dust reddening only if the reddening curve is steeper then the SMC curve in the ultraviolet and is very flat at longer wavelengths. Alternatively, the dominant spectral features can be explained by low-ionization BALs forming unusually wide, overlapping absorption troughs.Comment: 4 pages, 3 figures, accepted for publication in A&A Letter

The role of the hippocampus in passive and active spatial learning

Rats with lesions of the hippocampus or sham lesions were required in four experiments to escape from a square swimming pool by finding a submerged platform. Experiments 1 and 2 commenced with passive training in which rats were repeatedly placed on the platform in one corner—the correct corner—of a pool with distinctive walls. A test trial then revealed a strong preference for the correct corner in the sham but not the hippocampal group. Subsequent active training of being required to swim to the platform resulted in both groups acquiring a preference for the correct corner in the two experiments. In Experiments 3 and 4, rats were required to solve a discrimination between different panels pasted to the walls of the pool, by swimming to the middle of a correct panel. Hippocampal lesions prevented a discrimination being formed between panels of different lengths (Experiment 3), but not between panels showing lines of different orientations (Experiment 4); rats with sham lesions mastered both problems. It is suggested that an intact hippocampus is necessary for the formation of stimulus-goal associations that permit successful passive spatial leaning. It is further suggested that an intact hippocampus is not necessary for the formation of stimulus-response associations, except when they involve information about length or distance

Bursts, eclipses, dips and a refined position for the luminous low-mass X-ray binary in the globular cluster Terzan 6

GRS 1747-312 is a bright transient X-ray source in the globular cluster Terzan 6 with quasi-periodic outbursts approximately every 4.5 months. We carried out 2-60 keV target-of-opportunity observations during eight outbursts with the Proportional Counter Array on the RXTE satellite, for a total exposure time of 301 ks, and detect the first unambiguous thermonuclear X-ray bursts from this source. This identifies the compact accretor in this binary as a neutron star. The neutron star identification implies that twelve out of thirteen luminous (above 10^36 erg/s X-ray sources in Galactic globular clusters harbor neutron stars, with AC211's nature (in M15) remaining elusive. We observed 24 transitions of eclipses of the X-ray emitting region by the companion star and are able to improve the accuracy of the orbital period by a factor of 10^4. The period is P=0.514980303(7) d. We do not detect a period derivative with an upper limit of |\dot{P}/P|=3X10^-8 yr^{-1}. Archival Chandra data were analyzed to further refine the X-ray position, and the cluster's center of gravity was re-determined from optical data resulting in a correction amounting to 2 core radii. We find that GRS 1747-312 is 0.2+/-0.2 core radii from the cluster center.Comment: Accepted by A&

Association rules for rat spatial learning: the importance of the hippocampus for binding item identity with item location

Three cohorts of rats with extensive hippocampal lesions received multiple tests to examine the relationships between particular forms of associative learning and an influential account of hippocampal function (the cognitive map hypothesis). Hippocampal lesions spared both the ability to discriminate two different digging media and to discriminate two different room locations in a go/no-go task when each location was approached from a single direction. Hippocampal lesions had, however, differential effects on a more complex task (biconditional discrimination) where the correct response was signaled by the presence or absence of specific cues. For all biconditional tasks, digging in one medium (A) was rewarded in the presence of cue C, while digging in medium B was rewarded in the presences of cue D. Such biconditional tasks are “configural” as no individual cue or element predicts the solution (AC+, AD−, BD+, and BC−). When proximal context cues signaled the correct digging choice, biconditional learning was seemingly unaffected by hippocampal lesions. Severe deficits occurred, however, when the correct digging choice was signaled by distal room cues. Also, impaired was the ability to discriminate two locations when each location was approached from two directions. A task demand that predicted those tasks impaired by hippocampal damage was the need to combine specific cues with their relative spatial positions (“structural learning”). This ability makes it possible to distinguish the same cues set in different spatial arrays. Thus, the hippocampus appears necessary for configural discriminations involving structure, discriminations that potentially underlie the creation of cognitive maps

Multiwavelength Spectrum of the Black Hole XTE J1118+480 in Quiescence

We present an X-ray/UV/optical spectrum of the black hole primary in the X-ray nova XTE J1118+480 in quiescence at L_x = 4 x 10^{-9} of the Eddington luminosity. The Chandra, HST and MMT spectroscopic observations were performed simultaneously on 2002 January 12 UT. Because this 4.1-hr binary is located at b = 62 deg, the transmission of the ISM is very high (e.g., 70% at 0.3 keV). We present many new results for the quiescent state, such as the first far-UV spectrum and evidence for an 0.35 mag orbital modulation in the near-UV flux. However, the centerpiece of our work is the multiwavelength spectrum of XTE J1118+480, which we argue represents the canonical spectrum of a stellar-mass black hole radiating at L_x = 4 x 10^{-8.5} of the Eddington luminosity. This spectrum is comprised of two apparently disjoint components: a hard X-ray spectrum with a photon index Gamma = 2.02 +/- 0.16, and an optical/UV continuum that resembles a 13,000 K disk blackbody spectrum punctuated by several strong emission lines. We present a model of the source in which the accretion flow has two components: (1) an X-ray-emitting interior region where the flow is advection-dominated, and (2) a thin, exterior accretion disk with a truncated inner edge (R_tr ~ 10^4 Schwarzschild radii) that is responsible for the optical/UV spectrum. For D = 1.8 kpc, the luminosity of the X-ray component is L_x = 3.5 x 10^{30} erg/s (0.3-7 keV); the bolometric luminosity of the optical/UV component is 20 times greater.Comment: 52 pages, 16 figures, accepted by Ap

Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: the txt2heart Colombia randomised controlled trial (Preprint)

Background: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality in the world. Prevalence is estimated at around 100 million patients worldwide. There is evidence that antiplatelet agents and antihypertensive medication reduce the risk of new vascular events in this population, but treatment adherence is very low. Objective: We developed an intervention based on behavioral modification techniques delivered via mobile short message services (SMS) to increase the adherence to pharmacologic treatment on patients with prior history of ASCVD. Methods: We conducted a randomized controlled clinical trial for patients with a prior diagnosis of cardiovascular event such as acute myocardial infarction, unstable angina, cerebrovascular disease or peripheral artery disease in one centre in Colombia. Patients randomized to the intervention arm were assigned to receive SMS daily for the first 4 weeks, five SMS on week 5: three SMS per week from week 6, and one SMS from 8th week until 52nd week. Patients in the control arm received a monthly SMS reminding them of the next study appointment, requesting information about changes in phone number, thanking them for participating in the study and reminding them of the importance of the study. Primary endpoint was change in Low Density Lipoprotein-Cholesterol (LDL-C) and the secondary endpoints were change in thromboxane B2 levels, heart rate, systolic and diastolic blood pressure. Medication adherence was measured with the Medication Adherence Report Scale (MARS 5), mortality and new cardiac hospitalization were assessed at one year end point. A logistic regression analysis and bivariate testing was performed. Results: Nine hundred and thirty patients were randomized, 805 (87%) completed follow up, and were analyzed for the primary endpoint. There was no difference between arms in change of LDL-C at 12 months (P=.41). or for any of the secondary outcomes. No adverse events were reported. Conclusions: In our study we did not find evidence that a behavior modification intervention delivered by SMS improved LDL-C, blood pressure levels or adherence at 12 months. More research is needed to evaluate whether different SMS strategies including personalized messages and with different timing are effective; future studies should include mixed methods to understand better why, for whom and in which context (e.g. health system, social environment) SMS interventions work (or not) to improve adherence in patients with ASCVD. Clinical Trial: Clinicaltrial.gov NCT03098186. Date of registration: March 31st 201