A Theory on Information Security

This paper proposes a theory on information security. We argue that information security is imperfectly understood and aim to bring about an altered understanding of why efforts are made to engage in information security. The goal of information security is widely recognised as the confidentiality, integrity and availability of information however we argue that the goal is actually to simply create resources. This paper responds to calls for more theory in information systems, places the discussion in philosophical context and compares various definitions. It then identifies the key concepts of information security, describes the relationships between these concepts, as well as scope and causal explanations. The paper provides the theoretical base for understanding why information is protected, in addition to theoretical and practical implications and suggestions for future research

Towards Governance of Information Security Incident Response

Organizations are increasingly digitizing their business models to complement or even replace physical contact with customers and suppliers. With this shift online comes an increase in information security attacks, which are occurring more frequently due to the increased attack surface, vulnerabilities in security controls, and a target-rich environment. Organizations prevent attacks however some attacks are still successful and result in security incidents that degrade operations. When an organization is successfully breached, the organization must respond to the incident as quickly as possible to ensure continued operations and business resilience. However, guidance is lacking for governance of the response function. In a thematic review, we find good governance plays a key role in smooth and efficient incident response and this paper extends knowledge about governance of information security incident response by identifying key governance concepts that improve incident response efforts within organizations

Information Security Strategy in Organisations: Review, Discussion and Future Research Directions

Dependence on information, including for some of the world’s largest organisations such as governments and multi-national corporations, has grown rapidly in recent years. However, reports of information security breaches and their associated consequences continue to indicate that attacks are still escalating on organisations when conducting these information-based activities. Clearly, more research is needed to better understand how organisations should formulate strategy to secure their information. Through a thematic review of academic security literature, we (1) analyse the antecedent conditions that motivate the potential adoption of a comprehensive information security strategy, (2) the current perspectives of strategy and (3) the yields and benefits that could be enjoyed post-adoption. Our contributions include a definition of information security strategy. We argue for a paradigm shift to extend from internally-focussed protection of organisation-wide information towards a strategic view that considers the inter-organisational level. Our findings are then used to suggest future research directions

The impact of a supplementary medication review and counselling service within the oncology outpatient setting

The impact on the care of breast cancer patients, of a pharmacy technician-led medication review and counselling clinic, provided in an outpatient setting, was investigated using a controlled randomised study. Compared to the controls, clinic patients showed a significantly improved level of understanding of their chemotherapy support medication (95% CI for difference in mean knowledge rating scores=2.165–2.826, P<0.001) and a significant reduction in the median number of support items required (two compared to five in the control, P<0.001). This resulted in a significant reduction in mean medication expenditure per patient (£26.70 vs £10.20, 95% CI for the mean difference in cost £6.72–£26.26, P<0.001). The clinic was also associated with significant reductions in chemotherapy delays (P<0.001) and dose reductions due to side effects (P=0.003). Other benefits from the clinic were a reduction in pharmacy dispensing time and a highly significant reduction in pharmacy time spent resolving post-clinic prescription queries (P<0.001). Taking into account the initial technician training cost, the scheme represented an annual saving to the Trust of over £15 000. The clinic serves as a model for those wishing to improve outpatient services to breast cancer patients

Statistical properties of plasmaspheric hiss from Van Allen Probes observations

Van Allen Probes observations are used to statistically investigate plasmaspheric hiss wave properties. This analysis shows that the wave normal direction of plasmaspheric hiss is predominantly field aligned at larger L shells, with a bimodal distribution, consisting of a near‐field aligned and a highly oblique component, becoming apparent at lower L shells. Investigation of this oblique population reveals that it is most prevalent at L 0.01 (or f > 700 Hz), low geomagnetic activity levels, and between 1900 and 0900 magnetic local time. This structure is similar to that reported for oblique chorus waves in the equatorial region, perhaps suggesting a causal link between the two wave modes. Ray tracing results from HOTRAY confirm that it is feasible for these oblique chorus waves to be a source of the observed oblique plasmaspheric hiss population. The decrease in oblique plasmaspheric hiss occurrence rates during more elevated geomagnetic activity levels may be attributed to the increase in Landau resonant electrons causing oblique chorus waves to be more substantially damped outside of the plasmasphere. In turn, this restricts the amount of wave power that can access the plasmasphere and evolve into oblique plasmaspheric hiss. These results confirm that, despite the difference in location of this bimodal distribution compared to previous studies, a direct link between oblique equatorial chorus outside of the plasmasphere and oblique hiss at low L shells is plausible. As such, these results are in keeping with the existing theory of chorus as the source of plasmaspheric hiss

Gait and Balance Changes with Investigational Peripheral Nerve Cell Therapy during Deep Brain Stimulation in People with Parkinson’s Disease

Background: The efficacy of deep brain stimulation (DBS) and dopaminergic therapy is known to decrease over time. Hence, a new investigational approach combines implanting autologous injury-activated peripheral nerve grafts (APNG) at the time of bilateral DBS surgery to the globus pallidus interna. Objectives: In a study where APNG was unilaterally implanted into the substantia nigra, we explored the effects on clinical gait and balance assessments over two years in 14 individuals with Parkinson’s disease. Methods: Computerized gait and balance evaluations were performed without medication, and stimulation was in the off state for at least 12 h to best assess the role of APNG implantation alone. We hypothesized that APNG might improve gait and balance deficits associated with PD. Results: While people with a degenerative movement disorder typically worsen with time, none of the gait parameters significantly changed across visits in this 24 month study. The postural stability item in the UPDRS did not worsen from baseline to the 24-month follow-up. However, we measured gait and balance improvements in the two most affected individuals, who had moderate PD. In these two individuals, we observed an increase in gait velocity and step length that persisted over 6 and 24 months. Conclusions: Participants did not show worsening of gait and balance performance in the off therapy state two years after surgery, while the two most severely affected participants showed improved performance. Further studies may better address the long-term maintanenace of these results

Intervention planning and modification of the BUMP intervention: a digital intervention for the early detection of raised blood pressure in pregnancy

Background: Hypertensive disorders in pregnancy, particularly pre-eclampsia, pose a substantial health risk for both maternal and foetal outcomes. The BUMP (Blood Pressure Self-Monitoring in Pregnancy) interventions are being tested in a trial. They aim to facilitate the early detection of raised blood pressure through self-monitoring. This article outlines how the self-monitoring interventions in the BUMP trial were developed and modified using the person-based approach to promote engagement and adherence. Methods: Key behavioural challenges associated with blood pressure self-monitoring in pregnancy were identified through synthesising qualitative pilot data and existing evidence, which informed guiding principles for the development process. Social cognitive theory was identified as an appropriate theoretical framework. A testable logic model was developed to illustrate the hypothesised processes of change associated with the intervention. Iterative qualitative feedback from women and staff informed modifications to the participant materials. Results: The evidence synthesis suggested women face challenges integrating self-monitoring into their lives and that adherence is challenging at certain time points in pregnancy (for example, starting maternity leave). Intervention modification included strategies to address adherence but also focussed on modifying outcome expectancies, by providing messages explaining pre-eclampsia and outlining the potential benefits of self-monitoring. Conclusions: With an in-depth understanding of the target population, several methods and approaches to plan and develop interventions specifically relevant to pregnant women were successfully integrated, to address barriers to behaviour change while ensuring they are easy to engage with, persuasive and acceptable

RNA Sequencing of Human Peripheral Nerve in Response to Injury: Distinctive Analysis of the Nerve Repair Pathways

The development of regenerative therapies for central nervous system diseases can likely benefit from an understanding of the peripheral nervous system repair process, particularly in identifying potential gene pathways involved in human nerve repair. This study employed RNA sequencing (RNA-seq) technology to analyze the whole transcriptome profile of the human peripheral nerve in response to an injury. The distal sural nerve was exposed, completely transected, and a 1 to 2 cm section of nerve fascicles was collected for RNA-seq from six participants with Parkinson\u27s disease, ranging in age between 53 and 70 yr. Two weeks after the initial injury, another section of the nerve fascicles of the distal and pre-degenerated stump of the nerve was dissected and processed for RNA-seq studies. An initial analysis between the pre-lesion status and the postinjury gene expression revealed 3,641 genes that were significantly differentially expressed. In addition, the results support a clear transdifferentiation process that occurred by the end of the 2-wk postinjury. Gene ontology (GO) and hierarchical clustering were used to identify the major signaling pathways affected by the injury. In contrast to previous nonclinical studies, important changes were observed in molecular pathways related to antiapoptotic signaling, neurotrophic factor processes, cell motility, and immune cell chemotactic signaling. The results of our current study provide new insights regarding the essential interactions of different molecular pathways that drive neuronal repair and axonal regeneration in humans

Use of POES SEM-2 observations to examine radiation belt dynamics and energetic electron precipitation into the atmosphere

The coupling of the Van Allen radiation belts to the Earth's atmosphere through precipitating particles is an area of intense scientific interest. Currently, there are significant uncertainties surrounding the precipitating characteristics of medium energy electrons (> 20 keV), and even more uncertainties for relativistic electrons. In this paper we examine roughly 10 years of measurements of trapped and precipitating electrons available from the Polar Orbiting Environmental Satellites (POES)/Space Environment Monitor (SEM-2), which has provided long-term global data in this energy range. We show that the POES SEM-2 detectors suffer from some contamination issues that complicate the understanding of the measurements, but that the observations provide insight into the precipitation of energetic electrons from the radiation belts, and may be developed into a useful climatology for medium energy electrons. Electron contamination also allows POES/SEM-2 to provide unintended observations of > 700 keV relativistic electrons. Finally, there is an energy-dependent time delay observed in the POES/SEM-2 observations, with the relativistic electron enhancement (electrons > 800 keV) delayed by approximately one week relative to the > 30 keV electron enhancement, probably due to the timescales of the acceleration processes. Observations of trapped relativistic electron fluxes near the geomagnetic equator by GOES show similar delays, indicating a "coherency" to the radiation belts at high and low orbits, and also a strong link between trapped and precipitating particle fluxes. Such large delays should have consequences for the timing of the atmospheric impact of geomagnetic storms

Managing and monitoring equality and diversity in UK sport: An evaluation of the sporting equals Racial Equality Standard and its impact on organizational change

Despite greater attention to racial equality in sport in recent years, the progress of national sports organizations toward creating equality of outcomes has been limited in the United Kingdom. The collaboration of the national sports agencies, equity organizations and national sports organizations (including national governing bodies of sport) has focused on Equality Standards. The authors revisit an earlier impact study of the Racial Equality Standard in sport and supplement it with another round of interview material to assess changing strategies to manage diversity in British sport. In particular, it tracks the impact on organizational commitment to diversity through the period of the establishment of the Racial Equality Standard and its replacement by an Equality Standard that deals with other diversity issues alongside race and ethnicity. As a result, the authors question whether the new, generic Equality Standard is capable of addressing racial diversity and promoting equality of outcomes. © 2006 Sage Publications