Poetry of Spiritual Experience

The process of writing poetry, especially poetry with a spiritual focus, is far from cut-and-dry, but there are a few particular research elements that have helped me gain my footing in writing spiritually-focused poetry. Firstly, as you will see on the left, reading essays on poetics from the likes of Mary Karr and Don McKay—both of whom approach their own writing as avid readers of other poets—has taught me to give myself the time and space to reflect deeply on the possible ways poetry can reach out and touch experiences, specifically spiritual experiences, that are beyond language. Secondly, as you will see on the right, I have studied form, imagery, technique, and content through reading poetry collections from a wide variety of poets both inside and outside the Christian tradition. Finally, I took what I had gleaned from these poetics essays and poetry collections and applied those insights to my own poetry of spiritual experience. The process of creating that poetry is seen below

Assessing the Knowledge of Pediatric Mental Healthcare Providers on Sleep Disorders Associated with Child Psychiatric Illnesses: A Quality Improvement Project

Sleep hygiene plays a critical role in the cognitive, emotional, and physical development of a child. Sleep disturbances can negatively impact development and increase poor mental health outcomes for the pediatric population. Research evidence suggests children with psychiatric and behavioral diagnoses have a heightened risk for sleep disorders compared to the general pediatric population. With this bidirectional relationship between sleep disorders and psychiatric illnesses, pediatric psychiatric providers should address sleep disturbances along with mental health care to address the behavioral component and overall promote optimal care. However, literature highlights that providers receive limited training in sleep disorders. This quality improvement project aimed to assess the knowledge of pediatric psychiatric providers in managing sleep disorders. This project utilized a quasi-experimental pretest posttest study design with an in-person educational intervention in-between. Participants were providers recruited via secure email from a psychiatric outpatient clinic in Indianapolis, IN. Data was collected through pretest and posttest surveys via Qualtrics. Pretest and posttest questions addressed diagnosis and treatment of common sleep disorders associated with pediatric psychiatric illnesses. Ten participants completed the project. The data was analyzed via descriptive statistics and a paired t-test. There was an overall knowledge improvement of 20% and a paired t-test showed statistical significance between the pretest and posttest. The result of this quality improvement project exemplified the effectiveness of an educational intervention in improving pediatric psychiatric provider knowledge of managing sleep disorders. Ultimately, continuing education for psychiatric providers in sleep disorder management can enhance knowledge and promote comprehensive care

A human infertility-associated KASH5 variant promotes mitochondrial localization

KASH5 is the most recently identified member of the KASH domain family of tail anchored, outer nuclear membrane (ONM) and endoplasmic reticulum (ER) proteins. During meiosis prophase I, KASH5 and SUN1 form a complex that spans the nuclear envelope and which links the telomeres of meiotic chromosomes to cytoplasmic dynein. This connection is essential for homologous chromosome dynamics and pairing. A recent study identified a variant in human KASH5 (L535Q) that correlated with male infertility associated with azoospermia. However, no molecular mechanism was described. Here, we report that this amino acid substitution, within the KASH5 transmembrane domain (TMD) has no predicted effects on secondary structure. However, the overall hydrophobicity of the L535Q TMD, is calculated to be lower than the wild-type KASH5, based on the GES (Goldman–Engelman–Steitz) amino acid hydrophobicity scale. This change in hydrophobicity profoundly affects the subcellular localization of KASH5. Through a series of amino acid substitution studies, we show that the L535Q substitution perturbs KASH5 localization to the ER and ONM and instead results in mistargeting to the mitochondria membrane. We suggest that this mislocalization accounts for the infertility and azoospermia phenotype in patients.Other Information Published in: Scientific Reports License: https://creativecommons.org/licenses/by/4.0See article on publisher's website: http://dx.doi.org/10.1038/s41598-021-89439-2</p

NICER/NuSTAR Characterization of 4U 1957+11: A Near Maximally Spinning Black Hole Potentially in the Mass Gap

© 2023. The Author(s). Published by the American Astronomical Society. This is an open access article distributed under the Creative Commons Attribution License, to view a copy of the license, see: https://creativecommons.org/licenses/by/4.0/4U 1957+11 is a black hole candidate system that has been in a soft X-ray spectral state since its discovery. We present analyses of recent joint NICER and NuSTAR spectra, which are extremely well described by a highly inclined disk accreting into a near maximally spinning black hole. Owing to the broad X-ray coverage of NuSTAR, the fitted spin and inclination are strongly constrained for our hypothesized disk models. The faintest spectra are observed out to 20 keV, even though their hard tail components are almost absent when described with a simple corona. The hard tail increases with luminosity, but shows clear two-track behavior with one track having appreciably stronger tails. The disk spectrum color-correction factor is anticorrelated with the strength of the hard tail (e.g., as measured by the Compton y parameter). Although the spin and inclination parameters are strongly constrained for our chosen model, the mass and distance are degenerate parameters. We use our spectral fits, along with a theoretical prior on color-correction, an observational prior on likely fractional Eddington luminosity, and an observational prior on distance obtained from Gaia studies, to present mass and distance contours for this system. The most likely parameters, given our presumed disk model, suggest a 4.6 M ⊙ black hole at 7.8 kpc observed at luminosities ranging from ≈1.7% to 9% of Eddington. This would place 4U 1957+11 as one of the few actively accreting sources within the mass gap of ≈2–5 M ⊙ where there are few known massive neutron stars or low-mass black holes. Higher mass and distance, however, remain viable.Peer reviewe

Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease

Brain signal decoding promises significant advances in the development of clinical brain computer interfaces (BCI). In Parkinson's disease (PD), first bidirectional BCI implants for adaptive deep brain stimulation (DBS) are now available. Brain signal decoding can extend the clinical utility of adaptive DBS but the impact of neural source, computational methods and PD pathophysiology on decoding performance are unknown. This represents an unmet need for the development of future neurotechnology. To address this, we developed an invasive brain-signal decoding approach based on intraoperative sensorimotor electrocorticography (ECoG) and subthalamic LFP to predict grip-force, a representative movement decoding application, in 11 PD patients undergoing DBS. We demonstrate that ECoG is superior to subthalamic LFP for accurate grip-force decoding. Gradient boosted decision trees (XGBOOST) outperformed other model architectures. ECoG based decoding performance negatively correlated with motor impairment, which could be attributed to subthalamic beta bursts in the motor preparation and movement period. This highlights the impact of PD pathophysiology on the neural capacity to encode movement vigor. Finally, we developed a connectomic analysis that could predict grip-force decoding performance of individual ECoG channels across patients by using their connectomic fingerprints. Our study provides a neurophysiological and computational framework for invasive brain signal decoding to aid the development of an individualized precision-medicine approach to intelligent adaptive DBS

Immunomodulatory oligonucleotide IMT504: effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy

The immune responses of humans and animals to insults (i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged pro-inflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenchymal stem cell (MSC) transplant has proved to be an effective therapy in preclinical studies which evaluated a vast diversity of inflammatory conditions. MSCs lead to resolution of inflammation, preparation for regeneration and actual regeneration, and then ultimate return to normal baseline or homeostasis. However, in clinical trials of transplanted MSCs, the expectations of great medical benefit have not yet been fulfilled. As a practical alternative to MSC transplant, a synthetic drug with the capacity to boost endogenous MSC expansion and/or activation may also be effective. Regarding this, IMT504, the prototype of a major class of immunomodulatory oligonucleotides, induces in vivo expansion of MSCs, resulting in a marked improvement in preclinical models of neuropathic pain, osteoporosis, diabetes and sepsis. IMT504 is easily manufactured and has an excellent preclinical safety record. In the small number of patients studied thus far, IMT504 has been well-tolerated, even at very high dosage. Further clinical investigation is necessary to demonstrate the utility of IMT504 for resolution of inflammation and regeneration in a broad array of human diseases that would likely benefit from an immunoprotective/immunoregenerative therapy.Fil: Zorzopulos, Jorge. Immunotech; ArgentinaFil: Opal, Steven M.. Memorial Hospital of Rhode Island; Estados Unidos. Alpert Medical School; Estados UnidosFil: Hernando Insúa, Andrés. Fundación Pablo Cassara; ArgentinaFil: Rodriguez, Juan M.. Fundación Pablo Cassara; ArgentinaFil: Elías, Fernanda. Fundación Pablo Cassara; ArgentinaFil: Fló, Juan. Immunotech; ArgentinaFil: López, Ricardo A.. Imunotech; ArgentinaFil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Lux, Victoria Adela R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Coronel, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Franco, Raul. Imunotech; ArgentinaFil: Montaner, Alejandro D. Fundación Pablo Cassara; ArgentinaFil: Horn, David L. David Horn Llc; Estados Unido

Identification of the Changbaishan ‘Millennium’ (B-Tm) eruption deposit in the Lake Suigetsu (SG06) sedimentary archive, Japan: Synchronisation of hemispheric-wide palaeoclimate archives

The B-Tm tephra, dispersed during the highly explosive Changbaishan ‘Millennium’ eruption (ca. 940–950 CE) and a key marker layer within the Greenland ice cores, has now been identified in the Lake Suigetsu (SG06) sedimentary sequence, central Japan. The major element geochemistry of the volcanic glasses within this tephra layer are compared to a new glass dataset from the distal type-locality (Tomakomai Port, Hokkaido) and other published ‘Millennium’ eruption/B-Tm deposits, to verify this correlation. The discovery of the B-Tm tephra in the Lake Suigetsu record provides, to date, the most southerly identification of this ash and, crucially, the first direct tie-point between this high-resolution, mid-latitude palaeoclimate archive and the Greenland ice cores. These findings present significant encouragement for on-going research into the tephrostratigraphy of East Asia, focusing on the identification of widely-dispersed tephra layers which can facilitate the synchronisation of disparate palaeoclimate archives and thus enable the assessment of spatio-temporal variations in past climatic change