Leading and Managing the 21st Century Research University: Creating, Implementing, and Sustaining Strategic Change

Universities are competing in an environment in which only the most adaptable to sustainable change will prosper. In order to evolve in this challenging time, universities must embrace strategies for transformational change. This paper reviews two case studies that illustrate the universal applicability of theories of Change Science for achieving sustainable change in stressful times of prosperity and austerity. Understanding the phases of the Change Process that include Creating Vision, Implementing Vision, and Sustaining Vision can promote sustainable change directly related to the culture and mission of the institution

Pilgrim’s Progress: Lessons in Shared Governance

In the Spring of 2006, Southern Illinois University Edwardsville (SIUE) initiated a conversation to define a “Teacher-Scholar” Philosophy appropriate for the campus. In an experience similar to John Bunyan’s protagonist, Christian, in the classic 1678 allegory Pilgrim’s Progress, the SIUE faculty and administrators set off on a 21st century journey of discovery.[2] Our journey, however, was toward shared governance, rather than down the path to salvation. Like Bunyan’s Christian, we traveled metaphorically through the Town of Vanity, the Valley of Humiliation, the Slough of Despond, the Hill of Difficulty, and the Castle of Doubt. Unlike Christian, however, our journey of discovery ended before we crossed the River of Death and entered the Celestial City

HerMES: Candidate Gravitationally Lensed Galaxies and Lensing Statistics at Submillimeter Wavelengths

We present a list of 13 candidate gravitationally lensed submillimeter galaxies (SMGs) from 95 deg2 of the Herschel Multi-tiered Extragalactic Survey, a surface density of 0.14 ± 0.04 deg-2. The selected sources have 500 μm flux densities (S 500) greater than 100 mJy. Gravitational lensing is confirmed by follow-up observations in 9 of the 13 systems (70%), and the lensing status of the four remaining sources is undetermined. We also present a supplementary sample of 29 (0.31 ± 0.06 deg-2) gravitationally lensed SMG candidates with S 500 = 80-100 mJy, which are expected to contain a higher fraction of interlopers than the primary candidates. The number counts of the candidate lensed galaxies are consistent with a simple statistical model of the lensing rate, which uses a foreground matter distribution, the intrinsic SMG number counts, and an assumed SMG redshift distribution. The model predicts that 32%-74% of our S 500 >= 100 mJy candidates are strongly gravitationally lensed (μ >= 2), with the brightest sources being the most robust; this is consistent with the observational data. Our statistical model also predicts that, on average, lensed galaxies with S 500 = 100 mJy are magnified by factors of ~9, with apparently brighter galaxies having progressively higher average magnification, due to the shape of the intrinsic number counts. 65% of the sources are expected to have intrinsic 500 μm flux densities less than 30 mJy. Thus, samples of strongly gravitationally lensed SMGs, such as those presented here, probe below the nominal Herschel detection limit at 500 μm. They are good targets for the detailed study of the physical conditions in distant dusty, star-forming galaxies, due to the lensing magnification, which can lead to spatial resolutions of ~0.''01 in the source plane

Cancer genetic predisposition: information needs of patients irrespective of risk level

Increased insight into the information needs of people about cancer genetic predisposition could allow materials to be developed to improve decision-making for those at high risk, whilst those at lower risk could have their anxiety reduced without the need for referral to genetics services. This study aimed to identify information needs of patients concerned about a genetic predisposition to cancer, and explore how this varied according to risk perception, cancer worry, personal motivation and demographics. Stage 1 used semi-structured telephone interviews pre and post participants' genetic risk assessment. The findings informed stage two, a structured questionnaire survey of 1,112 patients, pre and post their genetic risk assessment. Participants were stratified by risk level and included those concerned about an inherited predisposition to breast, ovarian or colorectal cancer. About 512 (46%) responded with equal proportions of responders and non-responders across the risk categories. Findings indicated that irrespective of a person's actual or perceived level of risk, cancer worry, demographic background or personal motivation; priorities in the type of information required were similar. Greatest emphasis focused on information provision about how risk was assessed. Least important was acquiring an understanding about genes and inheritance patterns. Most participants reported difficulties accessing or finding information. Peoples' information needs are consistent irrespective of their risk level and therefore generalised information packages could be developed for anyone requesting cancer genetic risk assessment. Better information is likely to assist patients' understanding and ultimately increase concordance with recommended screening and preventative measures.Increased insight into the information needs of people about cancer genetic predisposition could allow materials to be developed to improve decision-making for those at high risk, whilst those at lower risk could have their anxiety reduced without the need for referral to genetics services. This study aimed to identify information needs of patients concerned about a genetic predisposition to cancer, and explore how this varied according to risk perception, cancer worry, personal motivation and demographics. Stage 1 used semi-structured telephone interviews pre and post participants' genetic risk assessment. The findings informed stage two, a structured questionnaire survey of 1,112 patients, pre and post their genetic risk assessment. Participants were stratified by risk level and included those concerned about an inherited predisposition to breast, ovarian or colorectal cancer. About 512 (46%) responded with equal proportions of responders and non-responders across the risk categories. Findings indicated that irrespective of a person's actual or perceived level of risk, cancer worry, demographic background or personal motivation; priorities in the type of information required were similar. Greatest emphasis focused on information provision about how risk was assessed. Least important was acquiring an understanding about genes and inheritance patterns. Most participants reported difficulties accessing or finding information. Peoples' information needs are consistent irrespective of their risk level and therefore generalised information packages could be developed for anyone requesting cancer genetic risk assessment. Better information is likely to assist patients' understanding and ultimately increase concordance with recommended screening and preventative measures

Spitzer-IRAC identification of Herschel-Atlas SPIRE sources

We use Spitzer-IRAC data to identify near-infrared counterparts to submillimeter galaxies detected with Herschel-SPIRE at 250 mu m in the Herschel Astrophysical Terahertz Large Area Survey. Using a likelihood ratio analysis we identify 146 reliable IRAC counterparts to 123 SPIRE sources out of the 159 in the survey area. We find that, compared to the field population, the SPIRE counterparts occupy a distinct region of the 3.6 and 4.5 mu m color-magnitude space, and we use this property to identify 23 further counterparts to 13 SPIRE sources. The IRAC identification rate of 86% is significantly higher than those that have been demonstrated with wide-field ground-based optical and near-IR imaging of Herschel fields. We estimate a false identification rate of 3.6%, corresponding to 4-5 sources. Among the 73 counterparts that are undetected in Sloan Digital Sky Survey, 57 have both 3.6 and 4.5 mu m coverage. Of these, 43 have [3.6]-[4.5] > 0, indicating that they are likely to be at z greater than or similar to 1.4. Thus, similar to 40% of identified SPIRE galaxies are likely to be high-redshift (z greater than or similar to 1.4) sources. We discuss the statistical properties of the IRAC-identified SPIRE galaxy sample including far-IR luminosities, dust temperatures, star formation rates, and stellar masses. The majority of our detected galaxies have 10(10)-10(11) L-circle dot total IR luminosities and are not intense starbursting galaxies as those found at z similar to 2, but they have a factor of 2-3 above average specific star formation rates compared to near-IR selected galaxy samples

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechanism coupling the pulmonary clock to innate immunity, involving both myeloid and bronchial epithelial cells in temporal gating and determining amplitude of response to inhaled endotoxin. Dual mutation of REV-ERBα and its paralog REV-ERBβ in bronchial epithelia further augmented inflammatory responses and chemokine activation, but also initiated a basal inflammatory state, revealing a critical homeostatic role for REV-ERB proteins in the suppression of the endogenous proinflammatory mechanism in unchallenged cells. However, REV-ERBα plays the dominant role, as deletion of REV-ERBβ alone had no impact on inflammatory responses. In turn, inflammatory challenges cause striking changes in stability and degradation of REV-ERBα protein, driven by SUMOylation and ubiquitination. We developed a novel selective oxazole-based inverse agonist of REV-ERB, which protects REV-ERBα protein from degradation, and used this to reveal how proinflammatory cytokines trigger rapid degradation of REV-ERBα in the elaboration of an inflammatory response. Thus, dynamic changes in stability of REV-ERBα protein couple the core clock to innate immunity

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechanism coupling the pulmonary clock to innate immunity, involving both myeloid and bronchial epithelial cells in temporal gating and determining amplitude of response to inhaled endotoxin. Dual mutation of REV-ERBα and its paralog REV-ERBß in bronchial epithelia further augmented inflammatory responses and chemokine activation, but also initiated a basal inflammatory state, revealing a critical homeostatic role for REV-ERB proteins in the suppression of the endogenous proinflammatory mechanism in unchallenged cells. However, REV-ERBα plays the dominant role, as deletion of REV-ERBß alone had no impact on inflammatory responses. In turn, inflammatory challenges cause striking changes in stability and degradation of REV-ERBα protein, driven by SUMOylation and ubiquitination. We developed a novel selective oxazole-based inverse agonist of REV-ERB, which protects REV-ERBα protein from degradation, and used this to reveal how proinflammatory cytokines trigger rapid degradation of REV-ERBα in the elaboration of an inflammatory response. Thus, dynamic changes in stability of REV-ERBα protein couple the core clock to innate immunity

The Herschel-SPIRE Legacy Survey (HSLS): the scientific goals of a shallow and wide submillimeter imaging survey with SPIRE

A large sub-mm survey with Herschel will enable many exciting science opportunities, especially in an era of wide-field optical and radio surveys and high resolution cosmic microwave background experiments. The Herschel-SPIRE Legacy Survey (HSLS), will lead to imaging data over 4000 sq. degrees at 250, 350, and 500 micron. Major Goals of HSLS are: (a) produce a catalog of 2.5 to 3 million galaxies down to 26, 27 and 33 mJy (50% completeness; 5 sigma confusion noise) at 250, 350 and 500 micron, respectively, in the southern hemisphere (3000 sq. degrees) and in an equatorial strip (1000 sq. degrees), areas which have extensive multi-wavelength coverage and are easily accessible from ALMA. Two thirds of the of the sources are expected to be at z > 1, one third at z > 2 and about a 1000 at z > 5. (b) Remove point source confusion in secondary anisotropy studies with Planck and ground-based CMB data. (c) Find at least 1200 strongly lensed bright sub-mm sources leading to a 2% test of general relativity. (d) Identify 200 proto-cluster regions at z of 2 and perform an unbiased study of the environmental dependence of star formation. (e) Perform an unbiased survey for star formation and dust at high Galactic latitude and make a census of debris disks and dust around AGB stars and white dwarfs

Toward the Theory of Enterprise: Dialogue Between Business and Economics Women Scholars

Studies on gender accounting are quite recent. Drawing upon criticism of dominant economic theories as developed within Feminist Economics, this paper aims to provide an original contribution to studies on gender accounting by establishing whether the (male) assumptions of the theory of the enterprise can be submitted to critical revision. As a foray into a field of research that we intend to further explore in the future, this paper focuses on the work of Italian women scholars Isa Marchini and Rosella Ferraris Franceschi. More specifically, it ponders the contribution they gave to the discipline in order to identify innovative insights that could enable original and enriching criticism to mainstream theories