Experiences of using digital mindfulness-based interventions: Rapid scoping review and thematic synthesis

Background: Digital mindfulness-based interventions (MBIs) are a promising approach to deliver accessible and scalable mindfulness training and have been shown to improve a range of health outcomes. However, the success of digital MBIs is reliant on adequate engagement, which remains a crucial challenge. Understanding people’s experiences of using digital MBIs and identifying the core factors that facilitate or act as barriers to engagement is essential to inform intervention development and maximize engagement and outcomes. Objective: This study aims to systematically map the literature on people’s experiences of using digital MBIs that target psychosocial variables (eg, anxiety, depression, distress, and well-being) and identify key barriers to and facilitators of engagement. Methods: We conducted a scoping review to synthesize empirical qualitative research on people’s experiences of using digital MBIs. We adopted a streamlined approach to ensure that the evidence could be incorporated into the early stages of intervention development. The search strategy identified articles with at least one keyword related to mindfulness, digital, user experience, and psychosocial variables in their title or abstract. Inclusion criteria specified that articles must have a qualitative component, report on participants’ experiences of using a digital MBI designed to improve psychosocial variables, and have a sample age range that at least partially overlapped with 16 to 35 years. Qualitative data on user experience were charted and analyzed using inductive thematic synthesis to generate understandings that go beyond the content of the original studies. We used the Quality of Reporting Tool to critically appraise the included sources of evidence. Results: The search identified 510 studies, 22 (4.3%) of which met the inclusion criteria. Overall, the samples were approximately 78% female and 79% White; participants were aged between 16 and 69 years; and the most used measures in intervention studies were mindfulness, psychological flexibility, and variables related to mental health (including depression, anxiety, stress, and well-being). All studies were judged to be adequately reported. We identified 3 themes characterizing barriers to and facilitators of engagement: responses to own practice (ie, negative reactions to one’s own practice are common and can deplete motivation), making mindfulness a habit (ie, creating a consistent training routine is essential yet challenging), and leaning on others (ie, those engaging depend on someone else for support). Conclusions: The themes identified in this review provide crucial insights as to why people frequently stop engaging with digital MBIs. Researchers and developers should consider using person-based coparticipatory methods to improve acceptability of and engagement with digital MBIs, increase their effectiveness, and support their translation to real-world use. Such strategies must be grounded in relevant literature and meet the priorities and needs of the individuals who will use the interventions

Health Costs of Reproduction are Minimal Despite High Fertility, Mortality and Subsistence Lifestyle

Women exhibit greater morbidity than men despite higher life expectancy. An evolutionary life history framework predicts that energy invested in reproduction trades-off against investments in maintenance and survival. Direct costs of reproduction may therefore contribute to higher morbidity, especially for women given their greater direct energetic contributions to reproduction. We explore multiple indicators of somatic condition among Tsimane forager-horticulturalist women (Total Fertility Rate = 9.1; n = 592 aged 15–44 years, n = 277 aged 45+). We test whether cumulative live births and the pace of reproduction are associated with nutritional status and immune function using longitudinal data spanning 10 years. Higher parity and faster reproductive pace are associated with lower nutritional status (indicated by weight, body mass index, body fat) in a cross-section, but longitudinal analyses show improvements in women’s nutritional status with age. Biomarkers of immune function and anemia vary little with parity or pace of reproduction. Our findings demonstrate that even under energy-limited and infectious conditions, women are buffered from the potential depleting effects of rapid reproduction and compound offspring dependency characteristic of human life histories

The Pennsylvania Environmental Resource Consortium: A State-Wide Collaborative Network for Sustainable, Outreach, Education, and Action

This paper explores the organizational theory, programs, and concomitant challenges faced by a state-level higher education consortium for sustainability in the United States, the Pennsylvania Environmental Resource Consortium (PERC). We provide insights for other institutions of higher education that may want to form consortia or consider changes to existing consortia. PERC members collaborate to advance sustainability on member campuses, in local communities, and across the Commonwealth. PERC envisions thriving, just communities on a healthy planet, and seeks to inspire higher education communities throughout the Commonwealth to lead transformational sustainability efforts through example, expertise, and collaboration. This chapter provides a brief theoretical background in PERC as a collaborative. It shares history and context for PERC’s mission and activities as well as an overview of its programs. It includes reflections on challenges to collaboration and coordination, including from COVID-19, changing digital technology, disparities among PERC institutions, accelerating sustainability challenges in the Anthropocene, anti-intellectualism and hyperpartisanship in the Commonwealth and the United States, and PERC’s own staffing, volunteerism, participation, and funding challenges. The chapter closes by revisiting the organization’s 2021–2025 Strategic Plan as an invitation to consider how cooperation, coordination, and collaboration among higher education institutions can positively impact sustainability across sectors

Tesseract supersonic business transport

This year, the senior level Aerospace Design class at Case Western Reserve University developed a conceptual design of a supersonic business transport. Due to the growing trade between Asia and the United States, a transpacific range was chosen for the aircraft. A Mach number of 2.2 was chosen, too, because it provides reasonable block times and allows the use of a large range of materials without a need for active cooling. A payload of 2,500 lbs. was assumed corresponding to a complement of nine passengers and crew, plus some light cargo. With these general requirements set, the class was broken down into three groups. The aerodynamics of the aircraft were the responsibility of the first group. The second developed the propulsion system. The efforts of both the aerodynamics and propulsion groups were monitored and reviewed for weight considerations and structural feasibility by the third group. Integration of the design required considerable interaction between the groups in the final stages. The fuselage length of the final conceptual design was 107.0 ft, while the diameter of the fuselage was 7.6 ft. The delta wing design consisted of an aspect ratio of 1.9 with a wing span of 47.75 ft and mid-chord length of 61.0 ft. A SNECMA MCV 99 variable-cycle engine design was chosen for this aircraft

Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease

Snakebite is a major neglected tropical health issue that affects over 5 million people worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year. Snakebite envenomation also causes innumerable morbidities specifically loss of limbs as a result of excessive tissue/muscle damage. Snake venom metalloproteases (SVMPs) are a predominant component of viper venoms, and are involved in the degradation of basement membrane proteins (particularly collagen) surrounding the tissues around the bite site. Although their collagenolytic properties have been established, the molecular mechanisms through which SVMPs induce permanent muscle damage are poorly understood. Here, we demonstrate the purification and characterisation of an SVMP from a viper (Crotalus atrox) venom. Mass spectrometry analysis confirmed that this protein is most likely to be a group III metalloprotease (showing high similarity to VAP2A) and has been referred to as CAMP (Crotalus atrox metalloprotease). CAMP displays both collagenolytic and fibrinogenolytic activities and inhibits CRP-XL-induced platelet aggregation. To determine its effects on muscle damage, CAMP was administered into the tibialis anterior muscle of mice and its actions were compared with cardiotoxin I (a three-finger toxin) from an elapid snake (Naja pallida) venom. Extensive immunohistochemistry analyses revealed that CAMP significantly damages skeletal muscles by attacking the collagen scaffold and other important basement membrane proteins, and prevents their regeneration through disrupting the functions of satellite cells. In contrast, cardiotoxin I destroys skeletal muscle by damaging the plasma membrane, but does not impact regeneration due to its inability to affect the extracellular matrix. Overall, this study provides novel insights into the mechanisms through which SVMPs induce permanent muscle damage

Decomposing DInSAR Time-Series into 3-D in Combination with GPS in the Case of Low Strain Rates: An Application to the Hyblean Plateau, Sicily, Italy

Differential Interferometric SAR (DInSAR) time-series techniques can be used to derive surface displacement rates with accuracies of 1 mm/year, by measuring the one-dimensional distance change between a satellite and the surface over time. However, the slanted direction of the measurements complicates interpretation of the signal, especially in regions that are subject to multiple deformation processes. The Simultaneous and Integrated Strain Tensor Estimation from Geodetic and Satellite Deformation Measurements (SISTEM) algorithm enables decomposition into a three-dimensional velocity field through joint inversion with GNSS measurements, but has never been applied to interseismic deformation where strain rates are low. Here, we apply SISTEM for the first time to detect tectonic deformation on the Hyblean Foreland Plateau in South-East Sicily. In order to increase the signal-to-noise ratio of the DInSAR data beforehand, we reduce atmospheric InSAR noise using a weather model and combine it with a multi-directional spatial filtering technique. The resultant three-dimensional velocity field allows identification of anthropogenic, as well as tectonic deformation, with sub-centimeter accuracies in areas of sufficient GPS coverage. Our enhanced method allows for a more detailed view of ongoing deformation processes as compared to the single use of either GNSS or DInSAR only and thus is suited to improve assessments of regional seismic hazard

The effectiveness of manual stretching in the treatment of plantar heel pain: a systematic review

Background: Plantar heel pain is a commonly occurring foot complaint. Stretching is frequently utilised as a treatment, yet a systematic review focusing only on its effectiveness has not been published. This review aimed to assess the effectiveness of stretching on pain and function in people with plantar heel pain. Methods: Medline, EMBASE, CINAHL, AMED, and The Cochrane Library were searched from inception to July 2010. Studies fulfilling the inclusion criteria were independently assessed, and their quality evaluated using the modified PEDro scale. Results: Six studies including 365 symptomatic participants were included. Two compared stretching with a control, one study compared stretching to an alternative intervention, one study compared stretching to both alternative and control interventions, and two compared different stretching techniques and durations. Quality rating on the modified Pedro scale varied from two to eight out of a maximum of ten points. The methodologies and interventions varied significantly between studies, making meta-analysis inappropriate. Most participants improved over the course of the studies, but when stretching was compared to alternative or control interventions, the changes only reached statistical significance in one study that used a combination of calf muscle stretches and plantar fascia stretches in their stretching programme. Another study comparing different stretching techniques, showed a statistically significant reduction in some aspects of pain in favour of plantar fascia stretching over calf stretches in the short term. Conclusions: There were too few studies to assess whether stretching is effective compared to control or other interventions, for either pain or function. However, there is some evidence that plantar fascia stretching may be more effective than Achilles tendon stretching alone in the short-term. Appropriately powered randomised controlled trials, utilizing validated outcome measures, blinded assessors and long-term follow up are needed to assess the efficacy of stretching

SUSY parameter determination at the LHC using cross sections and kinematic edges

We study the determination of supersymmetric parameters at the LHC from a global fit including cross sections and edges of kinematic distributions. For illustration, we focus on a minimal supergravity scenario and discuss how well it can be constrained at the LHC operating at 7 and 14 TeV collision energy, respectively. We find that the inclusion of cross sections greatly improves the accuracy of the SUSY parameter determination, and allows to reliably extract model parameters even in the initial phase of LHC data taking with 7 TeV collision energy and 1/fb integrated luminosity. Moreover, cross section information may be essential to study more general scenarios, such as those with non-universal gaugino masses, and distinguish them from minimal, universal, models.Comment: 22 pages, 8 figure