28 research outputs found
(E)-1-(1,3-Benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-one
In the molecule of the title compound, C14H16O3, all non-H atoms except for one methyl C atom lie on a crystallographic mirror plane. The conformation with respect to the C=C bond [1.3465 (12) Å] is trans. In the crystal, molecules are linked via C—H⋯O hydrogen bonds into C(5) chains propagating along [100]
Probing the morphology and anti-organic fouling behaviour of a polyetherimide membrane modified with hydrophilic organic acids as additives
A facile approach for the preparation of an organic antifouling polymer membrane has been developed using low molecular weight organic acids as additives. The presence of these additives in the membrane was analysed by FTIR spectroscopy. The properties of the modified membranes were investigated in terms of contact angle, water uptake capacity, SEM and AFM analysis. These additives exerted a strong impact on the rheological properties of the casting solution, thereby altering the membrane morphology, surface roughness, water flux and the hydrophilicity of the membranes, as compared to those of the pristine polyetherimide (PEI) membrane. The organic antifouling properties of the modified membrane were analysed by filtering both bovine serum albumin (BSA) and humic acid solutions. The results showed that the additives exhibited a remarkable improvement in the antifouling properties (FRR of 72%) and a humic acid rejection of up to 86%. These outcomes offer new insights into the use of cheaper and readily available organic acids as additives, compared to the traditional, synthetic polymer materials as additives in membrane preparation
trans-Tetracarbonylbis[tris(4-fluorophenyl)phosphane-κP]chromium(0)
In the title compound, [Cr(C18H12F3P)2(CO)4], the Cr atom is octahedrally coordinated by four carbonyl ligands and the two tertiary phosphanes that are trans to each other. The Cr atom and two carbonyl groups are on a twofold axis. The benzene rings attached to the phosphorus atom make dihedral angles of 80.32 (5), 52.91 (5) and 83.80 (5)° with each other. In the crystal, C—H⋯O and C—H⋯F intermolecular interactions form an infinite three-dimensional network
Koetjapic acid chloroform hemisolvate
The asymmetric unit of the title compound, C30H46O4·0.5CHCl3, consists of one koetjapic acid [systematic name: (3R,4aR,4bS,7S,8S,10bS,12aS)-7-(2-carboxyethyl)-3,4b,7,10b,12a-pentamethyl-8-(prop-1-en-2-yl)-1,2,3,4,4a,4b,5,6,7,8,9,10,10b,11,12,12a-hexadecahydrochrysene-3-carboxylic acid] molecule and one half-molecule of chloroform solvent, which is disordered about a twofold rotation axis. The symmetry-independent component is further disordered over two sites, with occupancies of 0.30 and 0.20. The koetjapic acid contains a fused four-ring system, A/B/C/D. The A/B, B/C and C/D junctions adopt E/trans/cis configurations, respectively. The conformation of ring A is intermediate between envelope and half-chair and ring B adopts an envelope conformation whereas rings C and D adopt chair conformations. A weak intramolecular C—H⋯O hydrogen bond is observed. The koetjapic acid molecules are linked into dimers by two pairs of intermolecular O—H⋯O hydrogen bonds. The dimers are stacked along the c axis
Cyclobenzaprinium salicylate
In the title molecular salt [systematic name: 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanaminium 2-hydroxybenzoate], C20H22N+·C7H5O3
−, the benzene rings of the cyclobenzaprinium cation are inclined with a dihedral angle of 61.66 (7)°. An intramolecular O—H⋯O hydrogen bond occurs within the salicylate anion, generating an S(6) ring. In the crystal, the cation and anion are linked by an N—H⋯O interaction
Cyclohexylammonium nitrate
In the title salt, C6H14N+.NO3_, the cyclohexyl ring adopts a
chair conformation. The ammonium group occupies an
equatorial position and the crystal struture is stabilized by
intermolecular N—H� � �O hydrogen-bonding interactions,
resulting in a three-dimensional network
Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors
Context
Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs).
Objective
To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients.
Design
12-year prospective, observational study.
Participants & Setting
We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases.
Interventions & Outcome
AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310).
Results
Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650).
Conclusions
Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course
(2E)-3-(6-Methoxynaphthalen-2-yl)-1-[4-(methylsulfanyl)phenyl]prop-2-en-1-one
The asymmetric unit of the title compound, C21H18O2S, consists of two crystallographically independent molecules (A and B). The molecules exist in a trans conformation with respect to the central C=C bond. The naphthalene ring system makes dihedral angles of 51.62 (12) (molecule A) and 52.69 (12)° (molecule B) with the benzene ring. In molecule A, the prop-2-en-1-one group forms dihedral angles of 22.84 (15) and 29.02 (12)° with the adjacent naphthalene ring system and benzene ring, respectively, whereas the corresponding angles are 30.04 (12) and 23.33 (12)° in molecule B. In the crystal, molecules are linked by intermolecular C—H...O hydrogen bonds into head-to-tail chains along the a axis. The crystal packing also features C—H...π interactions. The crystal studied was a pseudo-merohedral twin with twin law (100 0-10 00-1) and a refined component ratio of 0.6103 (16):0.3897 (16)