Democracia vs. eficiência: como alcançar equilíbrio em tempo de crise financeira

Resumo A administração pública é forçada a encontrar um equilíbrio entre eficiência e democracia na definição da sua agenda e curso de ação. Uma das características da administração pública é que todas as decisões devem refletir valores democráticos, para além de serem eficientes. No entanto, a reforma administrativa, motivada por dificuldades financeiras, tende a destacar a importância do desempenho financeiro, em detrimento dos aspetos democráticos nas políticas de gestão pública. Esta pesquisa visa analisar a relação e tensão entre a eficiência e a democracia à luz da mais recente crise financeira global. O trabalho utiliza uma abordagem quantitativa e recolhe dados de governos locais portugueses para testar o argumento de uma relação linear inversa de desempenho financeiro e procedimentos democráticos. Os resultados confirmam o argumento de uma relação inversa, definida por Waldo (1948). Adicionalmente, os resultados também permitem concluir que a crise financeira evidenciou o efeito negativo dos procedimentos democráticos no desempenho financeiro

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)

The New Urbanism: Expanding the Vision for the Design Professions

On September 14, the editors of the Berkeley Planning journal met with eight professionals and scholars to discuss a body of work we called "the new urbanism." This design movement has captured the attention of public officials, planners and citizens alike in recent years. We asked the participants to read at least two of four influential books and a recently published critique, to serve as a touchstone for the discussion; the result was a far-ranging discourse on the promise, pitfalls, and politics of urban planning and design in the 1990s. The participants brought very distinct concerns and first-hand experiences to the table. While agreeing that the new urbanism offered a much­ needed step in the right direction, they divided on whether its ideas, as now articulated, speak to the systems and attitudes that shape and divide suburban and urban communities today. Overall, we believe the participants pushed the discussion of this new movement ontoimportant ground

Who has conflicts with whom?: a social capital approach to conflict and creativity in teams

Extant team conflict research treats conflict as a shared perceptual team property whereby it is assumed that all of a team's members experience equivalent amounts of conflict. This traditional approach is silent concerning whether team members vary according to how much conflict each team member experiences with each of their team members. This customary treatment of team conflict as a shared perceptual property of the team has led to inconsistent findings in the empirical record concerning the predictive power of the team conflict construct for predicting a team's creativity. In an effort to provide conceptual and empirical clarity to this issue, the present dissertation utilized social capital theory and analysis to examine the relationship between team conflict and team creativity. With its explicit focus on dyadic interactions, social capital is argued to be a more appropriate lens than the conventional paradigm for understanding how and why conflicts between team members influence team members' ability to be creative. It is argued that a social capital approach provides a more rigorous and appropriate test of the theoretical and empirical justifications for the team conflict--team creativity relationship. The dissertation attempted to replicate and extend the findings of previous studies of team conflict and team creativity by utilizing measures of conflict derived using both sociometric and psychometric methods. Results from a lagged study of 132 teams engaged in a complex, 10-week business game simulation revealed that team conflict was predictive of team creativity using the traditional, yet less precise, psychometric method, but was not predictive of team creativity using the sociometric method. The study's inability to replicate previous research findings using the social capital approach calls into question the validity of traditional team conflict approaches for predicting team creativity. Further, the discrepant findings open a new line of inquiry addressing when and under what conditions the social capital approach to conflict predicts team creativity. (Published By University of Alabama Libraries

Erratum: The RA-MAP Consortium: a working model for academia–industry collaboration

This corrects the article DOI: 10.1038/nrrheum.2017.200

The RA-MAP Consortium: A working model for academia-industry collaboration

Collaboration can be challenging; nevertheless, the emerging successes of large, multi-partner, multi-national cooperatives and research networks in the biomedical sector have sustained the appetite of academics and industry partners for developing and fostering new research consortia. This model has percolated down to national funding agencies across the globe, leading to funding for projects that aim to realise the true potential of genomic medicine in the 21st century and to reap the rewards of 'big data'. In this Perspectives article, the experiences of the RA-MAP consortium, a group of more than 140 individuals affiliated with 21 academic and industry organizations that are focused on making genomic medicine in rheumatoid arthritis a reality are described. The challenges of multi-partner collaboration in the UK are highlighted and wide-ranging solutions are offered that might benefit large research consortia around the world

Political Control versus Bureaucratic Values: Reframing the Debate

The literature on political control of bureaucracy reveals that bureaucracies are highly responsive to political forces. This paper argues that the political control literature misses evidence from other academic literature that bears directly on this phenomenon. Specifically, researchers need to consider the values of the bureaucracy in any effort to assess the degree of political control. An empirical test is presented using a data set from public education. Results show bureaucratic values to be far more influential in explaining bureaucratic outputs and outcomes than political factors. These findings suggest that a reinterpretation of previous empirical research is urgently in order