Pullback Attractor for Nonautonomous Ginzburg-Landau Equation with Additive Noise

Long time behavior of stochastic Ginzburg-Landau equations with nonautonomous deterministic external forces, dispersion coefficients, and nonautonomous perturbations is studied. The domain is taken as a bounded interval I in R. By making use of Sobolev embeddings and Gialiardo-Nirenberg inequality we obtain the existence and upper semicontinuity of the pullback attractor in L2(I) for the equation. The upper semicontinuity shows the stability of attractors under perturbations

Regularity and structure of pullback attractors for reaction-diffusion type systems without uniqueness

In this paper, we study the pullback attractor for a general reaction-diffusion system for which the uniqueness of solutions is not assumed. We first establish some general results for a multi-valued dynamical system to have a bi-spatial pullback attractor, and then we find that the attractor can be backwards compact and composed of all the backwards bounded complete trajectories. As an application, a general reaction-diffusion system is proved to have an invariant (H, V )-pullback attractor A = {A(τ)}τ∈R. This attractor is composed of all the backwards compact complete trajectories of the system, pullback attracts bounded subsets of H in the topology of V, and moreover ∪ s6τ A(s) is precompact in V, ∀τ ∈ R. A non-autonomous Fitz-Hugh-Nagumo equation is studied as a specific example of the reaction–diffusion system.State Scholarship Fund (China)Junta de AndalucíaBrazilian-European partnership in Dynamical SystemsEuropean UnionNational Natural Science Foundation of Chin

Implementation of elastic prestack reverse-time migration using an efficient finite-difference scheme

Elastic reverse-time migration (RTM) can reflect the underground elastic information more comprehensively than single-component P-wave migration. One of the most important requirements of elastic RTM is to solve wave equations. The imaging accuracy and efficiency of RTM depends heavily on the algorithms used for solving wave equations. In this paper, we propose an efficient staggered-grid finite-difference (SFD) scheme based on a sampling approximation method with adaptive variable difference operator lengths to implement elastic prestack RTM. Numerical dispersion analysis and wavefield extrapolation results show that the sampling approximation SFD scheme has greater accuracy than the conventional Taylor-series expansion SFD scheme. We also test the elastic RTM algorithm on theoretical models and a field data set, respectively. Experiments presented demonstrate that elastic RTM using the proposed SFD scheme can generate better images than that using the Taylor-series expansion SFD scheme, particularly for PS images. Furthermore, the application of adaptive variable difference operator lengths can effectively improve the computational efficiency of elastic RTM

Dimensional Adjectives in Nuosu Yi

In this paper, we discuss two types of dimensional adjectives in Nuosu Yi (Tibeto- Burman), which we refer to as Positive adjectives (PAs) and Equative Adjectives (EAs). We show that PAs and EAs are subject to different distributions in gradation structures: EAs are only admissible in gradation structures that can be associated with measure phrases, which include differential comparatives (e.g., Ayi is 2 cm taller than Aguo. ) and degree questions (e.g., How tall is Ayi ?). PAs are licensed elsewhere, including comparatives that do not introduce a differential (e.g., Ayi is taller than Aguo. ), the intensification construction (e.g., Ayi is very tall ), the superlative construction (e.g., Ayi is the tallest ), etc. Assuming that measure phrases are degree-denoting expressions, we propose that the complimentary distribution of PAs and EAs in Nuosu Yi is due to their different semantics

Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer.

BackgroundWe previously developed a bladder cancer-specific ligand (PLZ4) that can specifically bind to both human and dog bladder cancer cells in vitro and in vivo. We have also developed a micelle nanocarrier drug-delivery system. Here, we assessed whether the targeting micelles decorated with PLZ4 on the surface could specifically target dog bladder cancer cells.Materials and methodsMicelle-building monomers (ie, telodendrimers) were synthesized through conjugation of polyethylene glycol with a cholic acid cluster at one end and PLZ4 at the other, which then self-assembled in an aqueous solution to form micelles. Dog bladder cancer cell lines were used for in vitro and in vivo drug delivery studies.ResultsCompared to nontargeting micelles, targeting PLZ4 micelles (23.2 ± 8.1 nm in diameter) loaded with the imaging agent DiD and the chemotherapeutic drug paclitaxel or daunorubicin were more efficient in targeted drug delivery and more effective in cell killing in vitro. PLZ4 facilitated the uptake of micelles together with the cargo load into the target cells. We also developed an orthotopic invasive dog bladder cancer xenograft model in mice. In vivo studies with this model showed the targeting micelles were more efficient in targeted drug delivery than the free dye (14.3×; P < 0.01) and nontargeting micelles (1.5×; P < 0.05).ConclusionTargeting micelles decorated with PLZ4 can selectively target dog bladder cancer cells and potentially be developed as imaging and therapeutic agents in a clinical setting. Preclinical studies of targeting micelles can be performed in dogs with spontaneous bladder cancer before proceeding with studies using human patients

Novel insights into circular RNAs in clinical application of carcinomas

Circular RNAs (circRNAs), formed by nonsequential back-splicing of pre-messenger RNA (pre-mRNA) transcripts, have been widely concerned in recent years. With advances in high-throughput RNA sequencing (RNA-seq) technology, previous work has revealed that a large number of circRNAs, which are endogenous, abundant and stable in mammalian cells, may be involved in atherosclerotic vascular disease risk, neurological disorders, prion diseases and carcinomas. Remarkably, interaction between circRNAs and microRNA has already been observed to perform a significant role in a variety of cancers, including gastric cancer and colorectal cancer. Recent work has suggested that circRNAs may play critical roles in the initiation and development of cancers and could become potential new biomarkers for cancers. Herein, we review the current understanding of the roles of circRNAs in cancers and the potential implications of circRNAs in cancer-targeted therapy

Exploring hypotheses on karez initiation and decline in the Flaming Mountains from a photo modelling campaign

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An early warning method for a slope based on the increment ratio of anchor cable internal force

Prestressed anchor cables are active reinforcement to improve slope stability. However, the anchoring is not a permanent guarantee of stability, and the slope retains a potential risk of instability. From the perspective of the internal force of anchor cables, a new early warning method for the safety of the slope is provided, and a slope analysis model is established. With the increase in the strength reduction factor, the internal force increment curves of anchor cables under different prestresses are obtained. The point corresponding to strength reduction factors λ1 and λ2 represents a warning point. Key conclusions are drawn as follows: (1) The internal force of an anchor cable can be used to judge the stability of the slope strengthened by a prestressed anchor cable. (2) A warning index based on the internal force increment ratio of anchor cables is established. (3) The internal force increment ratio of anchor cables eliminates the influence of the initial prestress and is convenient for engineering applications

The evolution of cloud and aerosol microphysics at the summit of Mt. Tai, China

The influence of aerosols, both natural and anthropogenic, remains a major area of uncertainty when predicting the properties and the behaviours of clouds and their influence on climate. In an attempt to better understand the microphysical properties of cloud droplets, the simultaneous variations in aerosol microphysics and their potential interactions during cloud life cycles in the North China Plain, an intensive observation took place from 17 June to 30 July 2018 at the summit of Mt. Tai. Cloud microphysical parameters were monitored simultaneously with number concentrations of cloud condensation nuclei (NCCN) at different supersaturations, PM2:5 mass concentrations, particle size distributions and meteorological parameters. Number concentrations of cloud droplets (NC), liquid water content (LWC) and effective radius of cloud droplets (reff) show large variations among 40 cloud events observed during the campaign. The low values of reff and LWC observed at Mt. Tai are comparable with urban fog. Clouds on clean days are more susceptible to the change in concentrations of particle number (NP), while clouds formed on polluted days might be more sensitive to meteorological parameters, such as updraft velocity and cloud base height. Through studying the size distributions of aerosol particles and cloud droplets, we find that particles larger than 150 nm play important roles in forming cloud droplets with the size of 5-10 μm. In general, LWC consistently varies with reff. As NC increases, reff changes from a trimodal distribution to a unimodal distribution and shifts to smaller size mode. By assuming a constant cloud thickness and ignoring any lifetime effects, increase in NC and decrease in reff would increase cloud albedo, which may induce a cooling effect on the local climate system. Our results contribute valuable information to enhance the understanding of cloud and aerosol properties, along with their potential interactions on the North China plain. © Author(s) 2020

Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs

Background Cervical cancer is one of the most common cancers in women worldwide. Malignant tumors develop resistance mechanisms and are less sensitive to or do not respond to irradiation. With the development of high-throughput sequencing technologies, circular RNA (circRNA) has been identified in an increasing number of diseases, especially cancers. It has been reported that circRNA can compete with microRNAs (miRNAs) to change the stability or translation of target RNAs, thus regulating gene expression at the transcriptional level. However, the role of circRNAs in cervical cancer and the radioresistance mechanisms of HeLa cells are unknown. The objective of this study is to investigate the role of circRNAs in radioresistance in HeLa cells. Methods High-throughput sequencing and bioinformatics analysis of irradiated and sham-irradiated HeLa cells. The reliability of high-throughput RNA sequencing was validated using quantitative real-time polymerase chain reaction. The most significant circRNA functions and pathways were selected by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. A circRNA–miRNA–target gene interaction network was used to find circRNAs associated with radioresistance. Moreover, a protein–protein interaction network was constructed to identify radioresistance-related hub proteins. Results High-throughput sequencing allowed the identification of 16,893 circRNAs involved in the response of HeLa cells to radiation. Compared with the control group, there were 153 differentially expressed circRNAs, of which 76 were up-regulated and 77 were down-regulated. GO covered three domains: biological process (BP), cellular component (CC) and molecular function (MF). The terms assigned to the BP domain were peptidyl-tyrosine dephosphorylation and regulation of cell migration. The identified CC terms were cell–cell adherens junction, nucleoplasm and cytosol, and the identified MF terms were protein binding and protein tyrosine phosphatase activity. The top five KEGG pathways were MAPK signaling pathway, endocytosis, axon guidance, neurotrophin signaling pathway, and SNARE interactions in vesicular transport. The protein–protein interaction analysis indicated that 19 proteins might be hub proteins. Conclusions CircRNAs may play a major role in the response to radiation. These findings may improve our understanding of the role of circRNAs in radioresistance in HeLa cells and allow the development of novel therapeutic approaches