Decay of the 3D Quasilinear Hyperbolic Equations with Nonlinear Damping

We investigate the 3D quasilinear hyperbolic equations with nonlinear damping which describes the propagation of heat wave for rigid solids at very low temperature, below about 20 K. The global existence and uniqueness of strong solutions are obtained when the initial data is near its equilibrium in the sense of H3-norm. Furthermore, if, additionally, Lp-norm (1≤p<6/5) of the initial perturbation is finite, we also prove the optimal Lp-L2 decay rates for such a solution without the additional technical assumptions for the nonlinear damping f(v) given by Li and Saxton

Differential effects of quercetin and its two derivatives (isorhamnetin and isorhamnetin-3- glucuronide) in inhibiting proliferation of human breast cancer MCF-7 cells

Quercetin (Que) has consistently been reported to be useful cytotoxic compound in vivo and in vitro, but little is known on its metabolites. Here we examined and compared cytotoxic effect of Que and its water-soluble metabolites, isorhamnetin (IS) and isorhamnetin-3-glucuronide (I3G) in human breast cancer MCF-7 cells, and explain their tumor-inhibitory mechanism and structure-function relationship. The results showed that Que, IS and I3G could dose-dependently inhibit the growth of MCF-7 cells, and the cytotoxic effect was ranked as Que > IS > I3G. Furthermore, Que, IS and I3G mediated the cell-cycle arrest principally in S phase, followed by the decrease in the number of G0/G1 and G2/M, and 70.8%, 68.9% and 49.8% MCF-7 tumor cells entered early phase apotosis when treated with 100 µM Que, IS and I3G for 48 h, respectively. Moreover, induction of apoptosis by Que, IS and I3G were accompanied with the marginal generation of intracellular ROS. Given these results, Que, IS and I3G possess strong cytotoxic effect through a ROS-dependent apoptosis pathway in MCF-7 cells

Solitary wave and periodic wave solutions for a class of singular p-laplacian systems with impulsive effects

This work deals with the existence of periodic wave solutions and nonexistence of solitary wave solutions for a class of second-order singular p-Laplacian systems with impulsive effects. A su_cient criterion for the solutions of the considered system is provided via an innovative method of the mountain pass theorem and an approximation technique. Some corresponding results in the literature can be enriched and extended

Two stage Robust Nash Bargaining based Benefit Sharing between Electric and HCNG Distribution Networks Bridged with SOFC

Hydrogen-enriched compressed natural gas (HCNG) networks have potentized sustainability and efficiency of integrated electricity and natural gas systems. However, paucity of benefit sharing risks the IENGS's development in multiple entities and bottlenecks its efficacy. To fill the gap, a robust Nash bargaining-based benefit sharing mechanism for HCNG-enabled IENGS is proposed

A New Model for Predicting Dynamic Surge Pressure in Gas and Drilling Mud Two-Phase Flow during Tripping Operations

Investigation of surge pressure is of great significance to the circulation loss problem caused by unsteady operations in management pressure drilling (MPD) operations. With full consideration of the important factors such as wave velocity, gas influx rate, pressure, temperature, and well depth, a new surge pressure model has been proposed based on the mass conservation equations and the momentum conservation equations during MPD operations. The finite-difference method, the Newton-Raphson iterative method, and the fourth-order explicit Runge-Kutta method (R-K4) are adopted to solve the model. Calculation results indicate that the surge pressure has different values with respect to different drill pipe tripping speeds and well parameters. In general, the surge pressure tends to increase with the increases of drill pipe operating speed and with the decrease of gas influx rate and wellbore diameter. When the gas influx occurs, the surge pressure is weakened obviously. The surge pressure can cause a significant lag time if the gas influx occurs at bottomhole, and it is mainly affected by pressure wave velocity. The maximum surge pressure may occur before drill pipe reaches bottomhole, and the surge pressure is mainly affected by drill pipe operating speed and gas influx rate

The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities

<p>Abstract</p> <p>Background</p> <p>Marek's disease virus (MDV) is an oncogenic herpesvirus, which causes malignant lymphoma in chickens. The Meq protein of MDV, which is expressed abundantly in MDV-infected cells and in Marek's disease (MD) tumor cells, functions as a transcriptional activator and has been proposed to play an important role in oncogenic transformation. Preliminary studies demonstrated that Meq is able to bind p53 <it>in vitro</it>, as demonstrated using a protein-binding assay. This observation prompted us to examine whether the interaction between Meq and p53 occurs in cells, and to investigate the biological significance of this interaction.</p> <p>Results</p> <p>We confirmed first that Meq interacted directly with p53 using a yeast two-hybrid assay and an immunoprecipitation assay, and we investigated the biological significance of this interaction subsequently. Exogenous expression of Meq resulted in the inhibition of p53-mediated transcriptional activity and apoptosis, as analyzed using a p53 luciferase reporter assay and a TUNEL assay. The inhibitory effect of Meq on transcriptional activity mediated by p53 was dependent on the physical interaction between these two proteins, because a Meq deletion mutant that lacked the p53-binding region lost the ability to inhibit p53-mediated transcriptional activity and apoptosis. The Meq variants L-Meq and S-Meq, but not VS-Meq and ∆Meq, which were expressed in MD tumor cells and MDV-infected cells, exerted an inhibitory effect on p53 transcriptional activity. In addition, ∆Meq was found to act as a negative regulator of Meq.</p> <p>Conclusions</p> <p>The Meq oncoprotein interacts directly with p53 and inhibits p53-mediated transcriptional activity and apoptosis. These findings provide valuable insight into the molecular basis for the function of Meq in MDV oncogenesis.</p