Topological Protection from Random Rashba Spin-Orbit Backscattering: Ballistic Transport in a Helical Luttinger Liquid

The combination of Rashba spin-orbit coupling and potential disorder induces a random current operator for the edge states of a 2D topological insulator. We prove that charge transport through such an edge is ballistic at any temperature, with or without Luttinger liquid interactions. The solution exploits a mapping to a spin 1/2 in a time-dependent field that preserves the projection along one randomly undulating component (integrable dynamics). Our result is exact and rules out random Rashba backscattering as a source of temperature-dependent transport, absent integrability-breaking terms.Comment: 6+3 pages, 2+1 figure

High level expression of Acidothermus cellulolyticus β-1, 4-endoglucanase in transgenic rice enhances the hydrolysis of its straw by cultured cow gastric fluid

<p>Abstract</p> <p>Background</p> <p>Large-scale production of effective cellulose hydrolytic enzymes is the key to the bioconversion of agricultural residues to ethanol. The goal of this study was to develop a rice plant as a bioreactor for the large-scale production of cellulose hydrolytic enzymes via genetic transformation, and to simultaneously improve rice straw as an efficient biomass feedstock for conversion of cellulose to glucose.</p> <p>Results</p> <p>In this study, the cellulose hydrolytic enzyme β-1, 4-endoglucanase (<it>E1</it>) gene, from the thermophilic bacterium <it>Acidothermus cellulolyticus</it>, was overexpressed in rice through <it>Agrobacterium</it>-mediated transformation. The expression of the bacterial <it>E1 </it>gene in rice was driven by the constitutive Mac promoter, a hybrid promoter of Ti plasmid mannopine synthetase promoter and cauliflower mosaic virus 35S promoter enhancer, with the signal peptide of tobacco pathogenesis-related protein for targeting the E1 protein to the apoplastic compartment for storage. A total of 52 transgenic rice plants from six independent lines expressing the bacterial E1 enzyme were obtained that expressed the gene at high levels without severely impairing plant growth and development. However, some transgenic plants exhibited a shorter stature and flowered earlier than the wild type plants. The E1 specific activities in the leaves of the highest expressing transgenic rice lines were about 20-fold higher than those of various transgenic plants obtained in previous studies and the protein amounts accounted for up to 6.1% of the total leaf soluble protein. A zymogram and temperature-dependent activity analyses demonstrated the thermostability of the E1 enzyme and its substrate specificity against cellulose, and a simple heat treatment can be used to purify the protein. In addition, hydrolysis of transgenic rice straw with cultured cow gastric fluid for one hour at 39°C and another hour at 81°C yielded 43% more reducing sugars than wild type rice straw.</p> <p>Conclusion</p> <p>Taken together, these data suggest that transgenic rice can effectively serve as a bioreactor for the large-scale production of active, thermostable cellulose hydrolytic enzymes. As a feedstock, direct expression of large amount of cellulases in transgenic rice may also facilitate saccharification of cellulose in rice straw and significantly reduce the costs for hydrolytic enzymes.</p

The relative roles of upper and lower tropospheric thermal contrasts and tropical influences in driving Asian summer monsoons

Summer thermal structure and winds over Asia show a larger land-ocean thermal gradient in the upper than in the lower troposphere, implying a bigger role of the upper troposphere in driving the Asian summer monsoon circulation. Using data from atmospheric re-analyses and model simulations, we show that the land-ocean thermal contrast in the mid-upper (200-500 hPa) troposphere (TCupper) contributes about three times as much as the thermal contrast in the mid-lower (500-850 hPa) troposphere (TClower) in determining both the strength and variations of Asian summer monsoon circulations. Tropical sea surface temperature anomalies associated with the annual cycle, El Niño-Southern Oscillation, decadal changes, and global warming all are accompanied with much larger variations and changes in TCupper than in TClower, partly due to enhanced latent heating aloft from convection. The variations and changes in TCupper and TClower are highly correlated with the strength of the South Asian Summer Monsoon (SASM) and the East Asian Summer Monsoon (EASM) in their respective sectors during the past 50-60 years. In particular, the weakening of the EASM since the 1950s is caused by the weakening mainly in TCupper and secondarily in TClower induced mainly by recent tropical surface warming, although spurious cooling over East Asia seen in reanalysis data may have enhanced this weakening. However, the strength of the SASM and EASM monsoons follows TCupper but decouples with TClower in the global warming case in the 21st century. The results suggest that the TCupper plays a dominant role and provides an efficient mechanism through which tropical oceans can influence extratropical monsoons. Key Points The land-sea T gradient is more important in the upper than in lower troposphere Tropical oceans influence extra-tropical monsoons through the upper troposphere Monsoon response to global warming depends on tropospheric warming patterns ©2013. American Geophysical Union. All Rights Reserved

Early Holocene monsoon instability and climatic optimum recorded by Chinese stalagmites

The timing and duration of the Holocene East Asian summer monsoon (EASM) maximum and the interpretation of Chinese stalagmite δ18O records have long been disputed. Notably, interpretations of Holocene EASM variations are frequently based on a single record or study area and are often contradictory. In this study, we conducted stable isotope analyses of four Holocene stalagmites from Chongqing, southwest China. The results reveal differences in the timing of the Holocene EASM maximum and to try to resolve the inconsistency we analyzed and statistically integrated a total of 16 Holocene stalagmite records from 14 caves in the EASM region. The resulting synthesized Holocene stalagmite δ18O (δ18Osyn) record is in agreement with other EASM records and confirms that stalagmite δ18O records are a valid indicator of EASM intensity, rather of local precipitation amount. The δ18Osyn record shows that the EASM intensified rapidly from the onset of the early Holocene; notably, however, there were distinct EASM oscillations in the early Holocene, consisting of three abrupt millennial-scale events. This indicates that, contrary to several previous interpretations, the early Holocene EASM was unstable. Subsequently, during 8–6 kyr BP, the EASM was relatively stable and strong, with the strongest monsoon occurring during 8–7 kyr BP. This evidence of a stable and strong mid-Holocene EASM in eastern China is in accord with the classical view of a mid-Holocene Optimum in China

Catheter Migration After Implantationan Intrathecal Baclofen Infusion Pump for Severe Spasticity: A Case Report

We report a case of intrathecal baclofen infusion pump implantation complicated by migration of the catheter tip. A 55-year-old man required an intrathecal baclofen infusion for severe spasticity 4 years after a cervical spinal cord injury with incomplete tetraparesis. Twelve months after initial implantation of the device, the patient began to experience a recurrence of trunk tightness and spasticity. Subsequent X-ray and computed tomography evaluations of the catheter system revealed pooling of contrast medium outside of the intrathecal distribution in the lumbar subcutaneous region of the back and therefore migration of the pump catheter tip. At surgical revision, emphasis was placed on minimizing the length of catheter outside of the spine and securing the catheter in the supraspinous fascia with a right-angled anchor. The distance between the anchors and the entry point of the catheter into the supraspinous fascia was also reduced to prevent slipping when the patient bends forward. After surgery, the patient's spasticity improved and, 1 year later, he has experienced no further complications during follow-up, requiring an average baclofen dose of 150 mg/day. Here, we describe several surgical methods intended to secure the intrathecal catheter and prevent catheter migration. Other complications related to catheter failure are also highlighted

Influencing Factors for Cure of Clonorchiasis by Praziquantel Therapy: Infection Burden and CYP3A5 Gene Polymorphism

Chemotherapy of clonorchiasis with praziquantel (PZQ) is effective but about 15% of treated cases have been reported uncured. The present study investigated correlation of single nucleotide polymorphisms (SNPs) of the cytochrome P450 gene, CYP3A5 and cure of clonorchiasis. A total of 346 egg passing residents were subjected and treated by 3 doses of 25 mg/kg PZQ. Reexamination recognized 33 (9.5%) uncured and 313 cured. Numbers of eggs per gram of feces (EPGs) before treatment were significantly lower in the cured group than in the uncured group (2,011.2±3,600.0 vs 4,998.5±7,012.0, P<0.001). DNAs of the subjects were screened for SNPs at 7 locations of CYP3A5 using PCR. In the uncured group, the SNP frequencies at g.-20555G>A and g.27526C>T of CYP3A5 were 15.2% and 9.1% while those were 3.8% and 1.0%, respectively, in the cured group. The cure rate was significantly lower in the cases with SNP at g.27526C>T and EPGs≥1,000. In conclusion, EPGs and SNPs of CYP3A5 are factors which influence cure of clonorchiasis by PZQ therapy. It is strongly suggested to recommend 2-day medication for individuals with high EPGs≥1,000

Ultra-stable long distance optical frequency distribution using the Internet fiber network

We report an optical link of 540 km for ultrastable frequency distribution over the Internet fiber network. The stable frequency optical signal is processed enabling uninterrupted propagation on both directions. The robustness and the performance of the link are enhanced by a cost effective fully automated optoelectronic station. This device is able to coherently regenerate the return optical signal with a heterodyne optical phase locking of a low noise laser diode. Moreover the incoming signal polarization variation are tracked and processed in order to maintain beat note amplitudes within the operation range. Stable fibered optical interferometer enables optical detection of the link round trip phase signal. The phase-noise compensated link shows a fractional frequency instability in 10 Hz bandwidth of 5x10-15 at one second measurement time and 2x10-19 at 30 000 s. This work is a significant step towards a sustainable wide area ultrastable optical frequency distribution and comparison network

Primulina pingnanensis, a new species of Gesneriaceae from Guangxi, China

A new species of Primulina, P. pingnanensis, from the Guangxi Zhuangzu Autonomous Region, China, is described and illustrated here. It is morphologically similar to P. orthandra but has significant differences in the bracts, corolla tube and lobes shape, as well as in the indumentum of the outer surface of the corolla, the filaments, the staminodes and the anthers. Colorful photographs and essential information of this new taxon are also provided, including detailed taxonomic description, distribution, habitat, the comparison table, and the IUCN conservation status. We also discuss a validation of new combination P. crassifolia and Chirita crassifolia