1,199 research outputs found
Monitoring and modeling infiltration–recharge dynamics of managed aquifer recharge with desalinated seawater
We study the relation between surface infiltration and groundwater
recharge during managed aquifer recharge (MAR) with desalinated seawater in
an infiltration pond, at the Menashe site that overlies the northern part of
the Israeli Coastal Aquifer. We monitor infiltration dynamics at multiple
scales (up to the scale of the entire pond) by measuring the ponding depth,
sediment water content and groundwater levels, using pressure sensors,
single-ring infiltrometers, soil sensors, and observation wells. During a
month (January 2015) of continuous intensive MAR
(2.45  ×  10<sup>6</sup> m<sup>3</sup> discharged to a 10.7 ha area),
groundwater level has risen by 17 m attaining full connection with the pond,
while average infiltration rates declined by almost 2 orders of magnitude
(from  ∼  11 to  ∼  0.4 m d<sup>−1</sup>). This reduction can be
explained solely by the lithology of the unsaturated zone that includes
relatively low-permeability sediments. Clogging processes at the pond-surface
– abundant in many MAR operations – are negated by the high-quality
desalinated seawater (turbidity  ∼  0.2 NTU, total dissolved solids
 ∼  120 mg L<sup>−1</sup>) or negligible compared to the low-permeability
layers. Recharge during infiltration was estimated reasonably well by simple
analytical models, whereas a numerical model was used for estimating
groundwater recharge after the end of infiltration. It was found that a
calibrated numerical model with a one-dimensional representative sediment
profile is able to capture MAR dynamics, including temporal reduction of
infiltration rates, drainage and groundwater recharge. Measured infiltration
rates of an independent MAR event (January 2016) fitted well to those
calculated by the calibrated numerical model, showing the model validity. The
successful quantification methodologies of the temporal groundwater recharge
are useful for MAR practitioners and can serve as an input for groundwater
flow models
Stellar Populations in the Phoenix Dwarf (dIrr/dSph) Galaxy as Observed by HST/WFPC2
We present HST/WFPC2 photometry of the central regions of the Phoenix dwarf.
Accurate photometry allows us to: 1) confirm the existence of the horizontal
branch previously detected by ground-based observations, and use it to
determine a distance to Phoenix, 2) clearly detect the existence of multiple
ages in the stellar population of Phoenix, 3) determine a mean metallicity of
the old red giant branch stars in Phoenix, and suggest that Phoenix has evolved
chemically over its lifetime, 4) extract a rough star formation history for the
central regions which suggests that Phoenix has been forming stars roughly
continuously over its entire lifetime.Comment: Accepted by AJ, 22 pages including 6 figures + 1 figure in JPEG
forma
Source blending effects on microlensing time-histograms and optical depth determination
Source blending in microlensing experiments is known to modify the Einstein
time of the observed events. In this paper, we have conducted Monte-Carlo
calculations, using the analytical relationships derived by Han (1999) to
quantify the effect of blending on the observed event time distribution and
optical depth. We show that short-time events are affected significantly by
source blending and that, for moderately blended sources, the optical depth
is globally overestimated, because of an underestimation of the
exposure. For high blending situations, on the opposite, blending leads to an
{\it under}estimation of the optical depth. Our results are in agreement with
the most recent optical depth determinations toward the Galactic Center of the
MACHO collaboration (Popowski et al. 2004) and the OGLE-II collaboration (Sumi
et al. 2005) that use clump giants (less affected by the blending effect) as
sources. The blending-corrected, lower optical depth toward the Galactic Bulge
is now in good agreement with the value inferred from galactic models,
reconciling theoretical and observational determinations.Comment: Accepted in Astronomy Astrophysics. Note that these calculations were
conducted in 2001, prior to the recent DIA analyses mentioned in the
references (see Alibert, Y. SF2A-conference, 2001
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice
Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in relation to CSF, and whether ISF tau is influenced by its aggregation are unknown. To address these issues, we developed a microdialysis technique to analyze monomeric ISF tau levels within the hippocampus of awake, freely moving mice. We detected tau in ISF of wild-type mice, suggesting that tau is released in the absence of neurodegeneration. ISF tau was significantly higher than CSF tau and their concentrations were not significantly correlated. Using P301S human tau transgenic mice (P301S tg mice), we found that ISF tau is fivefold higher than endogenous murine tau, consistent with its elevated levels of expression. However, following the onset of tau aggregation, monomeric ISF tau decreased markedly. Biochemical analysis demonstrated that soluble tau in brain homogenates decreased along with the deposition of insoluble tau. Tau fibrils injected into the hippocampus decreased ISF tau, suggesting that extracellular tau is in equilibrium with extracellular or intracellular tau aggregates. This technique should facilitate further studies of tau secretion, spread of tau pathology, the effects of different disease states on ISF tau, and the efficacy of experimental treatments
Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab
We evaluated neoadjuvant ipilimumab in patients with surgically operable regionally advanced melanoma in order to define markers of activity in the blood and tumor as assessed at baseline (before ipilimumab) and early on-treatment. Patients were treated with ipilimumab (10 mg/kg intravenously every 3 weeks x2 doses) bracketing surgery. Tumor and blood biospecimens were obtained at baseline and at surgery. Flow cytometry and immunohistochemistry for select biomarkers were performed. Thirty five patients were enrolled; IIIB (3; N2b), IIIC (32; N2c, N3), IV (2). Worst toxicities included Grade 3 diarrhea/colitis (5; 14%), hepatitis (2; 6%), rash (1; 3%), elevated lipase (3; 9%). Median follow up was 18 months: among 33 evaluable patients, median progression free survival (PFS) was 11 months, 95% CI (6.2-19.2). There was a significant decrease in circulating myeloid derived suppressor cells (MDSC). Greater decrease in circulating monocyte gate MDSC Lin1-/HLA-DR-/CD33+/CD11b+ was associated with improved PFS (p = 0.03). There was a significant increase in circulating regulatory T cells (Treg; CD4+CD25hi+Foxp3+) that, unexpectedly, was associated with improved PFS (HR = 0.57; p = 0.034). Baseline evidence of fully activated type I CD4+ and CD8+ antigen-specific T cell immunity against cancer-testis (NY-ESO-1) and melanocytic lineage (MART-1, gp100) antigens was detected and was significantly potentiated after ipilimumab. In tumor, there was a significant increase in CD8+ T cells after ipilimumab (p = 0.02). Ipilimumab induced increased tumor infiltration by fully activated (CD69+) CD3+/CD4+ and CD3 +/CD8+ T cells with evidence of induction/potentiation of memory T cells (CD45RO+). The change in Treg observed within the tumor showed an inverse relationship with clinical benefit and greater decrease in tumor MDSC subset Lin1-/HLA-DR-/CD33+/CD11b+ was associated with improved PFS at one year. Neoadjuvant evaluation revealed a significant immunomodulating role for ipilimumab on Treg, MDSC and effector T cells in the circulation and tumor microenvironment that warrants further pursuit in the quest for optimizing melanoma immunotherapy. © 2014 Tarhini et al
Chemical tagging can work: Identification of stellar phase-space structures purely by chemical-abundance similarity
Chemical tagging promises to use detailed abundance measurements to identify
spatially separated stars that were in fact born together (in the same
molecular cloud), long ago. This idea has not yielded much practical success,
presumably because of the noise and incompleteness in chemical-abundance
measurements. We have succeeded in substantially improving spectroscopic
measurements with The Cannon, which has now delivered 15 individual abundances
for ~100,000 stars observed as part of the APOGEE spectroscopic survey, with
precisions around 0.04 dex. We test the chemical-tagging hypothesis by looking
at clusters in abundance space and confirming that they are clustered in phase
space. We identify (by the k-means algorithm) overdensities of stars in the
15-dimensional chemical-abundance space delivered by The Cannon, and plot the
associated stars in phase space. We use only abundance-space information (no
positional information) to identify stellar groups. We find that clusters in
abundance space are indeed clusters in phase space. We recover some known
phase-space clusters and find other interesting structures. This is the
first-ever project to identify phase-space structures at survey-scale by blind
search purely in abundance space; it verifies the precision of the abundance
measurements delivered by The Cannon; the prospects for future data sets appear
very good.Comment: accepted for publication in the Ap
BEAMS: separating the wheat from the chaff in supernova analysis
We introduce Bayesian Estimation Applied to Multiple Species (BEAMS), an
algorithm designed to deal with parameter estimation when using contaminated
data. We present the algorithm and demonstrate how it works with the help of a
Gaussian simulation. We then apply it to supernova data from the Sloan Digital
Sky Survey (SDSS), showing how the resulting confidence contours of the
cosmological parameters shrink significantly.Comment: 23 pages, 9 figures. Chapter 4 in "Astrostatistical Challenges for
the New Astronomy" (Joseph M. Hilbe, ed., Springer, New York, forthcoming in
2012), the inaugural volume for the Springer Series in Astrostatistic
Structure of Disk Dominated Galaxies I. Bulge/Disk Parameters, Simulations, and Secular Evolution
(Abridged) A robust analysis of galaxy structural parameters, based on the
modeling of bulge and disk brightnesses in the BVRH bandpasses, is presented
for 121 face-on and moderately inclined late-type spirals. Each surface
brightness (SB) profile is decomposed into a sum of a generalized Sersic bulge
and an exponential disk. The reliability and limitations of our bulge-to-disk
(B/D) decompositions are tested with extensive simulations of galaxy brightness
profiles (1D) and images (2D). Galaxy types are divided into 3 classes
according to their SB profile shapes; Freeman Type-I and Type-II, and a third
``Transition'' class for galaxies whose profiles change from Type-II in the
optical to Type-I in the infrared. We discuss possible interpretations of
Freeman Type-II profiles. The Sersic bulge shape parameter for nearby Type-I
late-type spirals shows a range between n=0.1-2 but, on average, the underlying
surface density profile for the bulge and disk of these galaxies is adequately
described by a double-exponential distribution. We confirm a coupling between
the bulge and disk with a scale length ratio r_e/h=0.22+/-0.09, or
h_bulge/h_disk=0.13+/-0.06 for late-type spirals, in agreement with recent
N-body simulations of disk formation and models of secular evolution. This
ratio increases from ~0.20 for late-type spirals to ~0.24 for earlier types.
The similar scaling relations for early and late-type spirals suggest
comparable formation and/or evolution scenarios for disk galaxies of all Hubble
types.Comment: 78 pages with 23 embedded color figures + tables of galaxy structural
parameters. Accepted for publication in the Astrophysical Journal. The
interested reader is strongly encouraged to ignore some of the low res
figures within; instead, download the high resolution version from
http://www.astro.ubc.ca/people/courteau/public/macarthur02_disks.ps.g
Study of variable stars in the MOA data base: long-period red variables in the Large Magellanic Cloud
One hundred and forty six long-period red variable stars in the Large
Magellanic Cloud (LMC) from the three year MOA project database were analysed.
A careful periodic analysis was performed on these stars and a catalogue of
their magnitudes, colours, periods and amplitudes is presented. We convert our
blue and red magnitudes to band values using 19 oxygen-rich stars. A group
of red short-period stars separated from the Mira sequence has been found on a
(log P, K) diagram. They are located at the short period side of the Mira
sequence consistent with the work of Wood and Sebo (1996). There are two
interpretations for such stars; a difference in pulsation mode or a difference
in chemical composition. We investigated the properties of these stars together
with their colour, amplitude and periodicity. We conclude that they have small
amplitudes and less regular variability. They are likely to be higher mode
pulsators. A large scatter has been also found on the long period side of the
(log P, K) diagram. This is possibly a systematic spread given that the blue
band of our photometric system covers both standard B and V bands and affects
carbon-rich stars.Comment: 19 pages, 19 figures, accepted for publication in MNRA
Managed aquifer recharge with reverse-osmosis desalinated seawater: modeling the spreading in groundwater using stable water isotopes
The spreading of reverse-osmosis desalinated seawater (DSW) in the Israeli
coastal aquifer was studied using groundwater modeling and stable water
isotopes as tracers. The DSW produced at the Hadera seawater reverse-osmosis
(SWRO) desalination plant is recharged into the aquifer through an infiltration pond at the managed
aquifer recharge (MAR) site of Menashe, Israel. The distinct difference in isotope composition between DSW
(δ18O  =  1.41 ‰;
δ2H  =  11.34 ‰) and the natural groundwater
(δ18O  =  −4.48 ‰ to −5.43 ‰;
δ2H  =  −18.41 ‰ to −22.68 ‰) makes
the water isotopes preferable for use as a tracer compared to widely used
chemical tracers, such as chloride. Moreover, this distinct difference can be
used to simplify the system to a binary mixture of two end-members:
desalinated seawater and groundwater. This approach is validated through a
sensitivity analysis, and it is especially robust when spatial data of stable
water isotopes in the aquifer are scarce. A calibrated groundwater flow and
transport model was used to predict the DSW plume distribution in the aquifer
after 50Â years of MAR with DSW. The results suggest that after 50Â years,
94 % of the recharged DSW was recovered by the production wells at the
Menashe MAR site. The presented methodology is useful for predicting the
distribution of reverse-osmosis desalinated seawater in various downstream
groundwater systems.</p
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