Local starburst galaxies and their descendants

Despite strong interest in the starburst (hereafter SB) phenomenon, the concept remains ill-defined. We use a strict definition of SB to examine the statistical properties of local SB and post-starburst (hereafter PB) galaxies. We also seek relationships to active galaxies. Potential SB galaxies are selected from the SDSS DR7 and their stellar content is analysed. We apply an age dependent dust attenuation correction and derive star formation rates (SFR), ages and masses of the young and old populations. The photometric masses nicely agree with dynamical masses derived from the H-alpha emission line width. To select SB galaxies, we use the birthrate parameter b=SFR/, requiring b>=3. The PB sample is selected from the citerion EW(Hdelta_abs)>=6 A. Only 1% of star-forming galaxies are found to be SB galaxies. They contribute 3-6% to the stellar production and are therefore unimportant for the local star formation activity. The median SB age is 70 Myr, roughly independent of mass. The b-parameter strongly depends on burst age. Values close to b=60 are found at ages ~10 Myr, while almost no SBs are found at ages >1 Gyr. The median baryonic burst mass fraction of sub-L* galaxies is 5%, decreasing slowly with mass. The median mass fraction of the recent burst in the PB sample is 5-10%. The age-mass distribution of the progenitors of the PBs is bimodal with a break at log(M)~10.6 above which the ages are doubled. The SB and PB luminosity functions (hereafter LFs) follow each other closely until M_r~-21, when AGNs begin to dominate. The PB LF continues to follow the AGN LF while SB loose significance. This suggests that the number of luminous SBs is underestimated by about one dex at high luminosities, due to large amounts of dust and/or AGN blending. It also indicates that the SB phase preceded the AGN phase. We also discuss the conditions for global gas outflow caused by stellar feedback.Comment: Accepted for publication in Astronomy and Astrophysics. This is an extended, substantially revised and corrected version with partly modified conclusion

Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation

Fruit and vegetable consumption is associated at the population level with a protective effect against colorectal cancer. Phenolic compounds, especially abundant in berries, are of interest due to their putative anticancer activity. After consumption, however, phenolic compounds are subject to digestive conditions within the gastrointestinal tract that alter their structures and potentially their function. However, the majority of phenolic compounds are not efficiently absorbed in the small intestine and a substantial portion pass into the colon. We characterized berry extracts (raspberries, strawberries, blackcurrants) produced by in vitro-simulated upper intestinal tract digestion and subsequent fecal fermentation. These extracts and selected individual colonic metabolites were then evaluated for their putative anticancer activities using in vitro models of colorectal cancer, representing the key stages of initiation, promotion and invasion. Over a physiologically-relevant dose range (0–50 µg/ml gallic acid equivalents), the digested and fermented extracts demonstrated significant anti-genotoxic, anti-mutagenic and anti-invasive activity on colonocytes. This work indicates that phenolic compounds from berries undergo considerable structural modifications during their passage through the gastrointestinal tract but their breakdown products and metabolites retain biological activity and can modulate cellular processes associated with colon cancer

Rental Insights A COVID-19 Collection

This Collection offers insights from twenty of Australia’s leader academics and thinkers into the survey results of 15,000 Australian rental households. The Collection draws on data from The Australian Rental Housing Conditions Dataset funded by the Australian Research Council in partnership with six Australian universities as well an additional AHURI funded COVID-19 module

When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council

BackgroundAlthough most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking.ObjectiveTo guide those considering use of systemic therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient.MethodsA subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy. Topics were assigned to expert reviewers who performed a topic-specific literature review, referred to guidelines when available, and provided interpretation and expert opinion.ResultsWe recommend a systematic and holistic approach to assess patients with severe signs and symptoms of AD and impact on quality of life before systemic therapy. Steps taken before commencing systemic therapy include considering alternate or concomitant diagnoses, avoiding trigger factors, optimizing topical therapy, ensuring adequate patient/caregiver education, treating coexistent infection, assessing the impact on quality of life, and considering phototherapy.LimitationsOur work is a consensus statement, not a systematic review.ConclusionThe decision to start systemic medication should include assessment of severity and quality of life while considering the individual's general health status, psychologic needs, and personal attitudes toward systemic therapies

In Vitro Pharmacological Characterization of RXFP3 Allosterism: An Example of Probe Dependency

Recent findings suggest that the relaxin-3 neural network may represent a new ascending arousal pathway able to modulate a range of neural circuits including those affecting circadian rhythm and sleep/wake states, spatial and emotional memory, motivation and reward, the response to stress, and feeding and metabolism. Therefore, the relaxin-3 receptor (RXFP3) is a potential therapeutic target for the treatment of various CNS diseases. Here we describe a novel selective RXFP3 receptor positive allosteric modulator (PAM), 3-[3,5-Bis(trifluoromethyl)phenyl]-1-(3,4-dichlorobenzyl)-1-[2-(5-methoxy-1H-indol-3-yl)ethyl]urea (135PAM1). Calcium mobilization and cAMP accumulation assays in cell lines expressing the cloned human RXFP3 receptor show the compound does not directly activate RXFP3 receptor but increases functional responses to amidated relaxin-3 or R3/I5, a chimera of the INSL5 A chain and the Relaxin-3 B chain. 135PAM1 increases calcium mobilization in the presence of relaxin-3NH2 and R3/I5NH2 with pEC50 values of 6.54 (6.46 to 6.64) and 6.07 (5.94 to 6.20), respectively. In the cAMP accumulation assay, 135PAM1 inhibits the CRE response to forskolin with a pIC50 of 6.12 (5.98 to 6.27) in the presence of a probe (10 nM) concentration of relaxin-3NH2. 135PAM1 does not compete for binding with the orthosteric radioligand, [125I] R3I5 (amide), in membranes prepared from cells expressing the cloned human RXFP3 receptor. 135PAM1 is selective for RXFP3 over RXFP4, which also responds to relaxin-3. However, when using the free acid (native) form of relaxin-3 or R3/I5, 135PAM1 doesn't activate RXFP3 indicating that the compound's effect is probe dependent. Thus one can exchange the entire A-chain of the probe peptide while retaining PAM activity, but the state of the probe's c-terminus is crucial to allosteric activity of the PAM. These data demonstrate the existence of an allosteric site for modulation of this GPCR as well as the subtlety of changes in probe molecules that can affect allosteric modulation of RXFP3

Kreativitet : i marknadsföringsföretaget Liljedal Communication AB

Liljedal Communication AB is a marketing company with twelve employees in Örebro. In the marketing business is it extra important to work creatively to reach the target market with a message. Creativity is defined as the creation of new ideas where the idea is adequate, useful and feasible. Organisational creativity is created by individuals in the right environment for using their creativity. In this paper we present theories about creative individuals and the situation that affects their creativity. Furthermore theories are presented about different strategies that aim to increase creativity. The importance of the preparation of a problem is highlighted. Two interviews were conducted with the Vice President and Creative Director, moreover did the authors visit an idea meeting at the company. This is the base for the empirical part. The situation and strategies for creativity in the theoretical part and the empirical part is compared. Liljedal has a focus on becoming a creative organisation; this is noticeable both in their work environment and their working strategy. The conclusion is that Liljedals have good possibilities to work creatively. They also have a strategy worked out in detail for their creative work, this strategy is well conformed with the researchers strategies for increased creativity