Neural mechanisms of affective instability and cognitive control in substance use

Objective: We explored the impact of affect on cognitive control as this relates to individual differences in affective instability and substance use. Toward this end, we examined how different dimensions of affective instability interact to predict substance misuse and the effect of this on two event-related potential components, the reward positivity and the late positive potential, which are said to reflect the neural mechanisms of reward and emotion processing, respectively. Methods: We recorded the ongoing electroencephalogram from undergraduate students as they navigated two T-maze tasks in search of rewards. One of the tasks included neutral, pleasant, and unpleasant pictures from the International Affective Picture System. Participants also completed several questionnaires pertaining to substance use and personality. Results: A principal components analysis revealed a factor related to affective instability, which we named reactivity. This factor significantly predicted increased substance use. Individuals reporting higher levels of affective reactivity also displayed a larger reward positivity following stimuli with emotional content. Conclusion: The current study uncovered a group of high-risk substance users who were characterized by greater levels of affective reactivity and context-specific increased sensitivity to rewards. Significance: These results help to elucidate the complex factors underlying substance use and may facilitate the creation of individually-tailored treatment programs for those struggling with substance use disorders

Liquid Scintillator Time Projection Chamber Concept

Results are presented from a small-scale experiment to investigate the use of room temperature organic liquid scintillators as the active medium for a time projection chamber (TPC). The optical properties of liquid scintillators have long been known, but their ability to transport charge has remained, until now, largely untested. The idea of using room temperature liquids as an active medium for an ionisation chamber was first presented in \cite{EnglerTMS}. Since then the range of liquid scintillators available has been greatly developed. We present successful transport of ionization charges in a selection of both, pure organic liquid solvents and liquid scintillator cocktails over 20$\,$mm using a variety of electric drift field strengths. The target of this research is to offer a cost effective alternative to liquid noble gas detectors in neutrino physics.Comment: 6 pages, 5 figures, submitted to Proceedings 12th Pisa Meeting on Advanced Detectors, La Biodola, Isola d'Elba, Ital

Bootstrap Percolation on Complex Networks

We consider bootstrap percolation on uncorrelated complex networks. We obtain the phase diagram for this process with respect to two parameters: $f$, the fraction of vertices initially activated, and $p$, the fraction of undamaged vertices in the graph. We observe two transitions: the giant active component appears continuously at a first threshold. There may also be a second, discontinuous, hybrid transition at a higher threshold. Avalanches of activations increase in size as this second critical point is approached, finally diverging at this threshold. We describe the existence of a special critical point at which this second transition first appears. In networks with degree distributions whose second moment diverges (but whose first moment does not), we find a qualitatively different behavior. In this case the giant active component appears for any $f>0$ and $p>0$, and the discontinuous transition is absent. This means that the giant active component is robust to damage, and also is very easily activated. We also formulate a generalized bootstrap process in which each vertex can have an arbitrary threshold.Comment: 9 pages, 3 figure

Heterogeneous-k-core versus Bootstrap Percolation on Complex Networks

We introduce the heterogeneous-$k$-core, which generalizes the $k$-core, and contrast it with bootstrap percolation. Vertices have a threshold $k_i$ which may be different at each vertex. If a vertex has less than $k_i$ neighbors it is pruned from the network. The heterogeneous-$k$-core is the sub-graph remaining after no further vertices can be pruned. If the thresholds $k_i$ are $1$ with probability $f$ or $k \geq 3$ with probability $(1-f)$, the process forms one branch of an activation-pruning process which demonstrates hysteresis. The other branch is formed by ordinary bootstrap percolation. We show that there are two types of transitions in this heterogeneous-$k$-core process: the giant heterogeneous-$k$-core may appear with a continuous transition and there may be a second, discontinuous, hybrid transition. We compare critical phenomena, critical clusters and avalanches at the heterogeneous-$k$-core and bootstrap percolation transitions. We also show that network structure has a crucial effect on these processes, with the giant heterogeneous-$k$-core appearing immediately at a finite value for any $f > 0$ when the degree distribution tends to a power law $P(q) \sim q^{-\gamma}$ with $\gamma < 3$.Comment: 10 pages, 4 figure

Action Experience and Action Discovery in Medicated Individuals with Parkinson's Disease.

Parkinson's disease (PD) is a neurodegenerative disorder that markedly affects voluntary action. While regular dopamine treatment can help restore motor function, dopamine also influences cognitive portions of the action system. Previous studies have demonstrated that dopamine medication boosts action-effect associations, which are crucial for the discovery of new voluntary actions. In the present study, we investigated whether neural processes involved in the discovery of new actions are altered in PD participants on regular dopamine treatment, compared to healthy age-matched controls. We recorded brain electroencephalography (EEG) activity while PD patients and age-matched controls performed action discovery (AD) and action control tasks. We found that the novelty P3, a component normally present when there is uncertainty about the occurrence of the sensory effect, was enhanced in PD patients. However, AD was maintained in PD patients, and the novelty P3 demonstrated normal learning-related reductions. Crucially, we found that in PD patients the causal association between an action and its resulting sensory outcome did not modulate the amplitude of the feedback correct-related positivity (fCRP), an EEG component sensitive to the association between an action and its resulting effect. Collectively, these preliminary results suggest that the formation of long-term action-outcome representations may be maintained in PD patients on regular dopamine treatment, but the initial experience of action-effect association may be affected

Stress corrosion cracking in Al-Zn-Mg-Cu aluminum alloys in saline environments

Copyright 2013 ASM International. This paper was published in Metallurgical and Materials Transactions A, 44A(3), 1230 - 1253, and is made available as an electronic reprint with the permission of ASM International. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplications of any material in this paper for a fee or for commercial purposes, or modification of the content of this paper are prohibited.Stress corrosion cracking of Al-Zn-Mg-Cu (AA7xxx) aluminum alloys exposed to saline environments at temperatures ranging from 293 K to 353 K (20 °C to 80 °C) has been reviewed with particular attention to the influences of alloy composition and temper, and bulk and local environmental conditions. Stress corrosion crack (SCC) growth rates at room temperature for peak- and over-aged tempers in saline environments are minimized for Al-Zn-Mg-Cu alloys containing less than ~8 wt pct Zn when Zn/Mg ratios are ranging from 2 to 3, excess magnesium levels are less than 1 wt pct, and copper content is either less than ~0.2 wt pct or ranging from 1.3 to 2 wt pct. A minimum chloride ion concentration of ~0.01 M is required for crack growth rates to exceed those in distilled water, which insures that the local solution pH in crack-tip regions can be maintained at less than 4. Crack growth rates in saline solution without other additions gradually increase with bulk chloride ion concentrations up to around 0.6 M NaCl, whereas in solutions with sufficiently low dichromate (or chromate), inhibitor additions are insensitive to the bulk chloride concentration and are typically at least double those observed without the additions. DCB specimens, fatigue pre-cracked in air before immersion in a saline environment, show an initial period with no detectible crack growth, followed by crack growth at the distilled water rate, and then transition to a higher crack growth rate typical of region 2 crack growth in the saline environment. Time spent in each stage depends on the type of pre-crack (“pop-in” vs fatigue), applied stress intensity factor, alloy chemistry, bulk environment, and, if applied, the external polarization. Apparent activation energies (E a) for SCC growth in Al-Zn-Mg-Cu alloys exposed to 0.6 M NaCl over the temperatures ranging from 293 K to 353 K (20 °C to 80 °C) for under-, peak-, and over-aged low-copper-containing alloys (~0.8 wt pct), they are typically ranging from 20 to 40 kJ/mol for under- and peak-aged alloys, and based on limited data, around 85 kJ/mol for over-aged tempers. This means that crack propagation in saline environments is most likely to occur by a hydrogen-related process for low-copper-containing Al-Zn-Mg-Cu alloys in under-, peak- and over-aged tempers, and for high-copper alloys in under- and peak-aged tempers. For over-aged high-copper-containing alloys, cracking is most probably under anodic dissolution control. Future stress corrosion studies should focus on understanding the factors that control crack initiation, and insuring that the next generation of higher performance Al-Zn-Mg-Cu alloys has similar longer crack initiation times and crack propagation rates to those of the incumbent alloys in an over-aged condition where crack rates are less than 1 mm/month at a high stress intensity factor

Developing a Print on Demand Service in the Canadian Hydrographic Service

Recent events found the Canadian Hydrographic Service at a crossroads. A number of concurrent pressures seriously challenged the organisation's ability to produce, print, correct and distribute nautical charts, both from a financial perspective as well as a human resource perspective. While facing some difficult decisions, it became apparent that a number of relatively recent technologies could be combined to allow many of these challenges to be met. This paper describes the events that transpired, how the challenges were addressed using new technologies, and what the future may hold, as opportunities to refine and augment the application of new technologies are identified

On Bootstrap Percolation in Living Neural Networks

Recent experimental studies of living neural networks reveal that their global activation induced by electrical stimulation can be explained using the concept of bootstrap percolation on a directed random network. The experiment consists in activating externally an initial random fraction of the neurons and observe the process of firing until its equilibrium. The final portion of neurons that are active depends in a non linear way on the initial fraction. The main result of this paper is a theorem which enables us to find the asymptotic of final proportion of the fired neurons in the case of random directed graphs with given node degrees as the model for interacting network. This gives a rigorous mathematical proof of a phenomena observed by physicists in neural networks

Adventures in Interactive Compilation

Interactive compilation was proven to be a practical tool in the production of Chart 2011 and Chart 2048. The successful completion of these two charts has shown that applying computer-assisted techniques as an integral part of the construction of nautical charts is an effective alternative to traditional chart compilation. The advent of fast colour graphics devices and the increasing availability of digital hydrographic data requires innovative solutions to manage and use these data effectively

Cooperative Behavior of Kinetically Constrained Lattice Gas Models of Glassy Dynamics

Kinetically constrained lattice models of glasses introduced by Kob and Andersen (KA) are analyzed. It is proved that only two behaviors are possible on hypercubic lattices: either ergodicity at all densities or trivial non-ergodicity, depending on the constraint parameter and the dimensionality. But in the ergodic cases, the dynamics is shown to be intrinsically cooperative at high densities giving rise to glassy dynamics as observed in simulations. The cooperativity is characterized by two length scales whose behavior controls finite-size effects: these are essential for interpreting simulations. In contrast to hypercubic lattices, on Bethe lattices KA models undergo a dynamical (jamming) phase transition at a critical density: this is characterized by diverging time and length scales and a discontinuous jump in the long-time limit of the density autocorrelation function. By analyzing generalized Bethe lattices (with loops) that interpolate between hypercubic lattices and standard Bethe lattices, the crossover between the dynamical transition that exists on these lattices and its absence in the hypercubic lattice limit is explored. Contact with earlier results are made via analysis of the related Fredrickson-Andersen models, followed by brief discussions of universality, of other approaches to glass transitions, and of some issues relevant for experiments.Comment: 59 page