Explicit boundary form factors: the scaling Lee-Yang model

We provide explicit expressions for boundary form factors in the boundary scaling Lee-Yang model for operators with the mildest ultraviolet behavior for all integrable boundary conditions. The form factors of the boundary stress tensor take a determinant form, while the form factors of the boundary primary field contain additional explicit polynomials.Comment: 18 pages, References adde

Finite volume form factors in the presence of integrable defects

We developed the theory of finite volume form factors in the presence of integrable defects. These finite volume form factors are expressed in terms of the infinite volume form factors and the finite volume density of states and incorporate all polynomial corrections in the inverse of the volume. We tested our results, in the defect Lee-Yang model, against numerical data obtained by truncated conformal space approach (TCSA), which we improved by renormalization group methods adopted to the defect case. To perform these checks we determined the infinite volume defect form factors in the Lee-Yang model exactly, including their vacuum expectation values. We used these data to calculate the two point functions, which we compared, at short distance, to defect CFT. We also derived explicit expressions for the exact finite volume one point functions, which we checked numerically. In all of these comparisons excellent agreement was found.Comment: pdflatex, 34 pages, many figure

Finite volume form factors in the presence of integrable defects

We developed the theory of finite volume form factors in the presence of integrable defects. These finite volume form factors are expressed in terms of the infinite volume form factors and the finite volume density of states and incorporate all polynomial corrections in the inverse of the volume. We tested our results, in the defect Lee-Yang model, against numerical data obtained by truncated conformal space approach (TCSA), which we improved by renormalization group methods adopted to the defect case. To perform these checks we determined the infinite volume defect form factors in the Lee-Yang model exactly, including their vacuum expectation values. We used these data to calculate the two point functions, which we compared, at short distance, to defect CFT. We also derived explicit expressions for the exact finite volume one point functions, which we checked numerically. In all of these comparisons excellent agreement was found. © 2014 The Authors

Sensitive and Specific Fluorescent Probes for Functional Analysis of the Three Major Types of Mammalian ABC Transporters

An underlying mechanism for multi drug resistance (MDR) is up-regulation of the transmembrane ATP-binding cassette (ABC) transporter proteins. ABC transporters also determine the general fate and effect of pharmaceutical agents in the body. The three major types of ABC transporters are MDR1 (P-gp, P-glycoprotein, ABCB1), MRP1/2 (ABCC1/2) and BCRP/MXR (ABCG2) proteins. Flow cytometry (FCM) allows determination of the functional expression levels of ABC transporters in live cells, but most dyes used as indicators (rhodamine 123, DiOC2(3), calcein-AM) have limited applicability as they do not detect all three major types of ABC transporters. Dyes with broad coverage (such as doxorubicin, daunorubicin and mitoxantrone) lack sensitivity due to overall dimness and thus may yield a significant percentage of false negative results. We describe two novel fluorescent probes that are substrates for all three common types of ABC transporters and can serve as indicators of MDR in flow cytometry assays using live cells. The probes exhibit fast internalization, favorable uptake/efflux kinetics and high sensitivity of MDR detection, as established by multidrug resistance activity factor (MAF) values and Kolmogorov-Smirnov statistical analysis. Used in combination with general or specific inhibitors of ABC transporters, both dyes readily identify functional efflux and are capable of detecting small levels of efflux as well as defining the type of multidrug resistance. The assay can be applied to the screening of putative modulators of ABC transporters, facilitating rapid, reproducible, specific and relatively simple functional detection of ABC transporter activity, and ready implementation on widely available instruments

Optimization of a Do-It-Yourself Air Cleaner Design to Reduce Residential Air Pollution Exposure for a Community Experiencing Environmental Injustices

&nbsp; The large-scale deployment of Do-it-yourself (DIY) air cleaners, especially in communities that historically bear the brunt of air pollution exposure-related injustices, provides communities a cost-effective option to reduce personal indoor exposure to particulate matter. In this study, we developed nine air cleaner prototypes, altering filter depth and the number and type of filters, and compared their PM2.5 removal effectiveness and maintenance-related parameters prior to deployment in North Denver, Colorado homes. Prototypes containing multiple high efficiency particulate air filters with a minimum reporting value of 13 (MERV13) had higher clean air delivery rates (CADR, &gt;300 m3 h&minus;1) compared to prototypes using a single filter (100&ndash;200 m3 h&minus;1), but single-filter designs had comparable values of CADR normalized by initial and annual operating costs. Based on performance, cost, build time, and feedback from the community regarding concerns related to volatile organic compound exposure, the selected prototype (P9) used a combination of an activated carbon filter and single MERV13 filter with a 10.16 cm (4-inch) depth. Following this assessment, 120 of the selected air cleaner prototypes were built and deployed in homes around the communities in North Denver for two separate cohorts; feedback regarding their usage over the course of the deployment showed that in addition to the increased noise levels perceived by the participants, factors such as cold air flow from the air cleaner impacting the thermal comfort and aesthetics of the design reduced their usage time in homes. Future designs of DIY air cleaners could incorporate this feedback to help design improved features such as quieter air cleaners and real-time pollutant monitoring feedback to prompt users to keep them operational at all times of the day.</div

Multidrug-resistant Tuberculosis Management in Resource-limited Settings

Managing MDRTB through national programs can yield results similar to those seen in wealthier settings