Zelnate on Arrival Could Decrease the Likelihood of Subsequent Pulls in Suspect Bovine Respiratory Disease Complex Cases

Antimicrobial metaphylaxis is an important tool used for the prevention of Bovine Respiratory Disease Complex; a disease with a large economic impact that typically affects newly-weaned beef calves that are marketed and transported a distance from their origin. There are questions involving the potential benefit of Zelnate, a novel non-antibiotic technology designed to activate an animal’s natural immunity to fight Bovine Respiratory Disease Complex, being used either solely or in combination with metaphylaxis at the time of initial processing of high risk calves. More knowledge is also needed regarding the possible effects of repeated use of Zelnate when subsequent therapy is required in individual Bovine Respiratory Disease Complex cases. The objective of this study was to evaluate the effectiveness of Zelnate when used as part of an antimicrobial metaphylaxis treatment or when used in combination with an antibiotic when a calf is diagnosed with Bovine Respiratory Disease Complex

High Energy Digestible Fiber-based Diets Improve Efficiency in Growing Heifers

An inherent challenge of long hauled, highly stressed calves is decreased feed intake upon destination arrival. Highly stressed, newly received stocker calves not consuming adequate amounts of energy are prone to a variety of disorders such as Bovine Respiratory Disease Complex and decreased performance throughout the feeding period. One mechanism that can be used to increase energy intake upon arrival is to make the diet more energy dense. Often times, this is accomplished by the addition of cereal grains high in fermentable carbohydrate including starch. Unfortunately, this has also been linked to increasing morbidity due to metabolic disorders. The goal of this study was to analyze the effects of limit-fed diets containing increasing amounts of energy from highly digestible fiber in by-product feeds on health and performance of newly received stocker calves

Non-western contexts: the invisible half

Like many other disciplines within the broad area of social sciences (e.g., anthropology, gender studies, psychology, sociology, etc.), consumer research is also highly navigated by scholars from Western countries. This, however, does not mean, by any means, that consumer research is devoted to studying Western contexts only. As evident from the ever-increasing number of regional conferences (e.g., Asia-Pacific and Latin American conferences of the Association for Consumer Research) and non-Western students' enrolment in doctoral programs at Western universities, there are many more researchers (from non-Western countries) who are entering the field and enriching it by their colourful contributions. Yet, given the low number of publications on consumer research in non-Western contexts, it seems that our current knowledge in these societies has a long way to go to flourish. More specifically, and in the domain of consumption culture research, this gap is even further widened by the fact that the culture of consumption in such contexts is largely interpreted with reference to the 'grand narratives' of Western scholars (e.g., Foucault, Mafessoli, Bourdieu, Deleuze, Baudrillard, Nietzsche, Durkheim, Derrida, etc.). Therefore, from an ontological perspective, it seems that our existing knowledge about non-Western societies lies heavily on the 'theoretical structures' that are 'constructed' by Western philosophy as a set of ideas, beliefs, and practices (Said, 1978). As Belk (1995) reminds us, consumption culture always existed in all human societies. What makes contemporary societies different from that of our predecessors' is not the fact that consumption culture did not exist in those societies, but that consumption culture has become a prevailing feature in modern society (Slater, 1997; Lury, 1996; Fırat and Venkatesh, 1995; McCracken, 1988). Therefore, the nature and dynamics of consumption culture in each society should be studied not only against the sociocultural, historical, and economic background of a given context (Western or non-Western) but also with reference to the philosophical and epistemological viewpoints that analyse and interpret cultural practices of that society from within that culture. Addressing such issues, this paper discusses some of the key reasons for lack of theory development in the field from non-western contexts. The paper invites scholars in non-Western contexts to introduce the less articulated, and sometime hidden, body of knowledge from their own contexts into the field of marketing in general and consumer research in particular

Restricting Intake and Increasing Energy Improves Efficiency in Newly Received Growing Cattle and Zelnate Has No Effect

Objectives: Study effects of two limit-fed diets formulated to provide two levels of dietary energy and offered at two different intake rates to target similar gains and analyze the efficacy of a novel DNA-immunostimulant administered on arrival. Study Description: A 56-day pen study was conducted utilizing 370 Angus × Brahman heifers shipped from Florida (1,455 mi) to study the effects of limit-feeding at 2 intakes based on prior research conducted at the Kansas State University Beef Stocker Unit, Manhattan, KS, to achieve similar gains and effects of Zelnate under the dietary conditions. The Bottom Line: Limit-feeding a higher-energy, lower-roughage diet at 2.2% of body weight daily is a more efficient feeding strategy than offering a higher-roughage, lower-energy diet at 2.4% of body weight daily to achieve similar gains, and Zelnate administered on arrival had no effect on performance or health

Programming a Variety of Gains Is Possible by Controlling Intake of a Single High-Energy By-Product-Based Diet Early in the Receiving/Growing Period Without Affecting Efficiency

Objective: Analyze the effects on performance when feeding a high-energy by-product-based diet to newly received growing cattle. Description: A total of 400 Angus × Hereford heifers originating from Montana were used to determine the effects on performance when intake of a high-energy corn by-product-based diet is increased to near ad libitum intake. The Bottom Line: One high-energy diet based on wet corn gluten feed can be offered to achieve a variety of gains efficiently by only altering the amount of feed offered

Wet Distiller’s Grains and Wet Corn Gluten with Dry-Rolled or Whole-Shelled Corn in High-Energy Limit-Fed Diets Do Not Affect Growing Cattle Performance

Objective: Compare wet distiller’s grains plus solubles and wet corn gluten feed with dry-rolled or whole-shelled corn in a novel programmed-feeding strategy being developed at the Kansas State University Beef Stocker Unit. Description: A total of 320 crossbred steers were used to determine the effects of two corn by-products and methods of corn processing, utilizing a high-energy limit-fed feeding strategy. The Bottom Line: Kansas producers have the option of feeding corn by-product and whether or not to process corn in a high-energy limit-fed feeding strategy without the risk of negatively affecting performance

Increased Dietary Energy in Limit-fed Diets Does Not Affect Immune Function, Inflammation, or Stress, but Health Status Does

Objectives: Measure effects of limit-feeding high-energy diets on the immune system, stress, and inflammation as well as differences in these parameters between healthy and sick animals under the dietary conditions. Study Description: Heifers from 4 dietary treatments were used to study the effects of limit-feeding and increased dietary energy on immune function, inflammation (indicated by elevated levels of haptoglobin), stress, and differences in these parameters between healthy and morbid animals consuming the different diets. The Bottom Line: Limit-feeding high-energy diets does not negatively affect immune function, cause stress, or promote inflammation, and morbid animals have significantly higher haptoglobin levels

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

A proline-to-serine substitution at position 56 in the gene encoding vesicle-associated membrane protein-associated protein B (VAPB; VAPBP56S) causes some dominantly inherited familial forms of motor neuron disease, including amyotrophic lateral sclerosis (ALS) type-8. Here, we show that expression of ALS mutant VAPBP56S but not wild-type VAPB in neurons selectively disrupts anterograde axonal transport of mitochondria. VAPBP56S-induced disruption of mitochondrial transport involved reductions in the frequency, velocity and persistence of anterograde mitochondrial movement. Anterograde axonal transport of mitochondria is mediated by the microtubule-based molecular motor kinesin-1. Attachment of kinesin-1 to mitochondria involves the outer mitochondrial membrane protein mitochondrial Rho GTPase-1 (Miro1) which acts as a sensor for cytosolic calcium levels ([Ca2+]c); elevated [Ca2+]c disrupts mitochondrial transport via an effect on Miro1. To gain insight into the mechanisms underlying the VAPBP56S effect on mitochondrial transport, we monitored [Ca2+]c levels in VAPBP56S-expressing neurons. Expression of VAPBP56S but not VAPB increased resting [Ca2+]c and this was associated with a reduction in the amounts of tubulin but not kinesin-1 that were associated with Miro1. Moreover, expression of a Ca2+ insensitive mutant of Miro1 rescued defective mitochondrial axonal transport and restored the amounts of tubulin associated with the Miro1/kinesin-1 complex to normal in VAPBP56S-expressing cells. Our results suggest that ALS mutant VAPBP56S perturbs anterograde mitochondrial axonal transport by disrupting Ca2+ homeostasis and effecting the Miro1/kinesin-1 interaction with tubulin

Digestibility of Dry Matter is Better and Manure Output is Lower in Growing Cattle Limit-Fed a High-Energy Diet During the Growing Phase Compared to a Traditional Roughage-Based Diet Fed for Ad Libitum Intake

Objective: Evaluate the impact on intake and digestion of a high-energy diet limit-fed at 85% of the ad libitum daily consumption of a roughage-based diet on a dry matter (DM) basis compared to a traditional roughage-based growing diet in growing cattle. Study Description: Eight ruminally cannulated crossbred Angus heifers (body weight = 450 ± 24 lb) were used in a cross-over design with two consecutive 15-day periods at the Kansas State University Beef Stocker Unit. Two dietary treatments were fed: (1) 45 Mcal of net energy for gain (NEg) per 100 lb of DM fed for ad libitum DM intake (45AL), or (2) 60 Mcal NEg per 100 lb of DM limit-fed at 85% of 45AL diet intake on a DM basis (60LF85%). Both diets contained 40% of DM as Sweet Bran (Cargill Animal Nutrition, Blair, NE). Heifers were fed once daily at 10:00 a.m. Each 15-day period included 10 days for diet adaption, 4 days for fecal sampling, and 1 day for ruminal sampling. Daily nutrient intake was measured and apparent total-tract diet digestibility using chromic oxide (Cr2O3) marker was determined. Results: Ruminal pH was greater (P \u3c 0.01) from 10:00 p.m. to 10:00 a.m. just before feeding for heifers fed 60LF85% than 45AL heifers. Diet digestibility was improved by 5.2% (P \u3c 0.01) and fecal DM output 35% lower (P \u3c 0.01) in heifers fed 60LF85% than heifers fed 45AL. The Bottom Line: Heifers limit-fed a high-energy diet based on corn and Sweet Bran had greater ruminal pH during the overnight hours, better diet digestibility, and reduced output of manure than heifers full-fed a traditional roughage-based diet

Total Tract Dry Matter Digestibility and Proportions of Ruminal Propionate Are Increased in High-Energy Limit-Fed Diets Based Primarily on Wet Corn Gluten Feed

Objectives: Study digestion and characteristics of digestion of high-energy limit-fed diets based primarily on wet corn gluten feed. Study Description: Six ruminally-cannulated Jersey crossbred steers were used to measure total tract diet digestibility, passage rate, volatile fatty acid, and ammonia production, and ruminal pH when limit-feeding high-energy diets based primarily on wet corn gluten feed. The Bottom Line: High-energy limit-fed diets based primarily on wet corn gluten feed are 15% more digestible and produce a higher concentration of energy yielding volatile fatty acid compared to low-energy full-fed diets without apparent disruptions in ruminal fermentation or health