Detection of positrons from Breit-Wheeler pair formation

This work explores the experimental observation of the Breit-Wheeler process, first described by Gregory Breit and John A. Wheeler in 1934 [1], where two photons collide to form an electron positron pair from the quantum vacuum. The specific challenge thereby is the low cross section of a few 10e 29 m2 or 0.1 b combined with the requirement of photon energies in the range of mega electronvolt. Such beams can be provided by particle accelerators, for instance LCLS at SLAC or the European XFEL at DESY. Experiments exploring photon photon collisions with conventional accelerators were done in the past, for example E144 at SLAC in 1997 [2], however the two photon process described by Breit and Wheeler has not yet been observed. Over the last few decades, novel laser driven plasma based particle accelerators (LWFA) made significant progress [3, 4, 5, 6], allowing the production of the required photon beams to study the Breit-Wheeler process at pure laser facilities [7, 8, 9]. The work in hand explores the challenges related to such an experiment specifically at high power laser facilities using the example of Astra Gemini, a multi 100TW dual beam system at the CLF in England. In an experiment, multi 100MeV γ-rays from LWFA electron bremsstrahlung and 1-2 keV x-rays from Germanium M-L shell transition radiation are collided to produce pairs through the Breit-Wheeler process. A detection system to measure those pairs composed of a permanent magnet beam line and shielded single particle detectors is developed and tested within this thesis. The acquired data allows an estimate of the requirements for future experiments to measure the two-photon Breit-Wheeler process

Progress in hybrid plasma wakefield acceleration

Plasma wakefield accelerators can be driven either by intense laser pulses (LWFA) or by intense particle beams (PWFA). A third approach that combines the complementary advantages of both types of plasma wakefield accelerator has been established with increasing success over the last decade and is called hybrid LWFA→PWFA. Essentially, a compact LWFA is exploited to produce an energetic, high-current electron beam as a driver for a subsequent PWFA stage, which, in turn, is exploited for phase-constant, inherently laser-synchronized, quasi-static acceleration over extended acceleration lengths. The sum is greater than its parts: the approach not only provides a compact, cost-effective alternative to linac-driven PWFA for exploitation of PWFA and its advantages for acceleration and high-brightness beam generation, but extends the parameter range accessible for PWFA and, through the added benefit of co-location of inherently synchronized laser pulses, enables high-precision pump/probing, injection, seeding and unique experimental constellations, e.g., for beam coordination and collision experiments. We report on the accelerating progress of the approach achieved in a series of collaborative experiments and discuss future prospects and potential impact

Detection of positrons from Breit-Wheeler pair formation

This work explores the experimental observation of the Breit-Wheeler process, first described by Gregory Breit and John A. Wheeler in 1934 [1], where two photons collide to form an electron positron pair from the quantum vacuum. The specific challenge thereby is the low cross section of a few 10e 29 m2 or 0.1 b combined with the requirement of photon energies in the range of mega electronvolt. Such beams can be provided by particle accelerators, for instance LCLS at SLAC or the European XFEL at DESY. Experiments exploring photon photon collisions with conventional accelerators were done in the past, for example E144 at SLAC in 1997 [2], however the two photon process described by Breit and Wheeler has not yet been observed. Over the last few decades, novel laser driven plasma based particle accelerators (LWFA) made significant progress [3, 4, 5, 6], allowing the production of the required photon beams to study the Breit-Wheeler process at pure laser facilities [7, 8, 9]. The work in hand explores the challenges related to such an experiment specifically at high power laser facilities using the example of Astra Gemini, a multi 100TW dual beam system at the CLF in England. In an experiment, multi 100MeV γ-rays from LWFA electron bremsstrahlung and 1-2 keV x-rays from Germanium M-L shell transition radiation are collided to produce pairs through the Breit-Wheeler process. A detection system to measure those pairs composed of a permanent magnet beam line and shielded single particle detectors is developed and tested within this thesis. The acquired data allows an estimate of the requirements for future experiments to measure the two-photon Breit-Wheeler process

Investigation of functional and structural interaction of TRPM8 and Gq

In der vorliegenden Arbeit wurde die strukturelle und funktionale Interaktion zwischen TRPM8 und Gq untersucht. Es konnte gezeigt werden, dass der als Ionenkanal beschriebene Kälte- und Mentholrezeptor TRPM8 nach Aktivierung auch eine metabotrope Signalkaskade über Gq anschalten kann, was zu einer Erhöhung der Konzentration des sekundären Botenstoffs Ca$^{2+}$ führt. Nach Aktivierung des TRPM8 wird einerseits ein Einstrom von Ca$^{2+}$ über die Pore, andererseits eine Freisetzung von Ca$^{2+}$ aus intrazellulären Speichern (Endoplasmatisches Retikulum, ER) ermöglicht. Dies ist durch Aktivierung des Gq Proteins nach TRPM8 Stimulierung durch Menthol oder Kälte möglich. Die $\alpha$-Untereinheit des G-Proteins kann eine Phospholipase C aktivieren, welche membranständiges PIP$_{2}$ in DAG und IP$_{3}$ spaltet. IP$_{3}$ ist in der Lage durch das Zytosol zu diffundieren und IP$_{3}$-Rezeptoren an den ER-Membranen zu öffnen, was zu einer Erhöhung der intrazellulären Ca$^{2+}$-Konzentration führt

Calibration and cross-laboratory implementation of scintillating screens for electron bunch charge determination.

We revise the calibration of scintillating screens commonly used to detect relativistic electron beams with low average current, e.g., from laser-plasma accelerators, based on new and expanded measurements that include higher charge density and different types of screens than previous work [Buck et al., Rev. Sci. Instrum. 81, 033301 (2010)]. Electron peak charge densities up to 10 nC/mm2 were provided by focused picosecond-long electron beams delivered by the Electron Linac for beams with high Brilliance and low Emittance (ELBE) at the Helmholtz-Zentrum Dresden-Rossendorf. At low charge densities, a linear scintillation response was found, followed by the onset of saturation in the range of nC/mm2. The absolute calibration factor (photons/sr/pC) in this linear regime was measured to be almost a factor of 2 lower than that reported by Buck et al. retrospectively implying a higher charge in the charge measurements performed with the former calibration. A good agreement was found with the results provided by Glinec et al. [Rev. Sci. Instrum. 77, 103301 (2006)]. Furthermore long-term irradiation tests with an integrated dose of approximately 50 nC/mm2 indicate a significant decrease of the scintillation efficiency over time. Finally, in order to enable the transfer of the absolute calibration between laboratories, a new constant reference light source has been developed