On the thermal buffering of naturally ventilated buildings through internal thermal mass

In this paper we examine the role of thermal mass in buffering the interior temperature of a naturally ventilated building from the diurnal fluctuations in the environment. First, we show that the effective thermal mass which is in good thermal contact with the air is limited by the diffusion distance into the thermal mass over one diurnal temperature cycle. We also show that this effective thermal mass may be modelled as an isothermal mass. Temperature fluctuations in the effective thermal mass are attenuated and phase-shifted from those of the interior air, and therefore heat is exchanged with the interior air. The evolution of the interior air temperature is then controlled by the relative magnitudes of (i) the time for the heat exchange between the effective thermal mass and the air; (ii) the time for the natural ventilation to replace the air in the space with air from the environment; and (iii) the period of the diurnal oscillations of the environment. Through analysis and numerical solution of the governing equations, we characterize a number of different limiting cases. If the ventilation rate is very small, then the thermal mass buffers the interior air temperature from fluctuations in the environment, creating a near-isothermal interior. If the ventilation rate increases, so that there are many air changes over the course of a day, but if there is little heat exchange between the thermal mass and interior air, then the interior air temperature locks on to the environment temperature. If there is rapid thermal equilibration of the thermal mass and interior air, and a high ventilation rate, then both the thermal mass and the interior air temperatures lock on to the environment temperature. However, in many buildings, the more usual case is that in which the time for thermal equilibration is comparable to the period of diurnal fluctuations, and in which ventilation rates are moderate. In this case, the fluctuations of the temperature of the thermal mass lag those of the interior air, which in turn lag those of the environment. We consider the implications of these results for the use of thermal mass in naturally ventilated buildings

Identification of the age-period-cohort model and the extended chain-ladder model

We consider the identification problem that arises in the age-period-cohort models as well as in the extended chain-ladder model. We propose a canonical parameterization based on the accelerations of the trends in the three factors. This parameterization is exactly identified and eases interpretation, estimation and forecasting. The canonical parameterization is applied to a class of index sets which have trapezoidal shapes, including various Lexis diagrams and the insurance-reserving triangles

Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children

BACKGROUND: Descriptions of the pharmacokinetics and metabolism of morphine and its metabolites in young children are scant. Previous studies have not differentiated the effects of size from those related to age during infancy. METHODS: Postoperative children 0-3 yr old were given an intravenous loading dose of morphine hydrochloride (100 micro g kg(-1) in 2 min) followed by either an intravenous morphine infusion of 10 micro g h(-1) kg(-1) (n=92) or 3-hourly intravenous morphine boluses of 30 micro g kg(-1) (n=92). Additional morphine (5 micro g kg(-1)) every 10 min was given if the visual analogue (VAS, 0-10) pain score was >/=4. Arterial blood (1.4 ml) was sampled within 5 min of the loading dose and at 6, 12 and 24 h for morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). The disposition of morphine and formation clearances of morphine base to its glucuronide metabolites and their elimination clearances were estimated using non-linear mixed effects models. RESULTS: The analysis used 1856 concentration observations from 184 subjects. Population parameter estimates and their variability (%) for a one-compartment, first-order elimination model were as follows: volume of distribution 136 (59.3) litres, formation clearance to M3G 64.3 (58.8) litres h(-1), formation clearance to M6G 3.63 (82.2) litres h(-1), morphine clearance by other routes 3.12 litres h(-1) per 70 kg, elimination clearance of M3G 17.4 (43.0) litres h(-1), elimination clearance of M6G 5.8 (73.8) litres h(-1). All parameters are standardized to a 70 kg person using allometric 3/4 power models and reflect fully mature adult values. The volume of distribution increased exponentially with a maturation half-life of 26 days from 83 litres per 70 kg at birth; formation clearance to M3G and M6G increased with a maturation half-life of 88.3 days from 10.8 and 0.61 litres h(-1) per 70 kg respectively at birth. Metabolite formation decreased with increased serum bilirubin concentration. Metabolite clearance increased with age (maturation half-life 129 days), and appeared to be similar to that described for glomerular filtration rate maturation in infants. CONCLUSION: M3G is the predominant metabolite of morphine in young children and total body morphine clearance is 80% that of adult values by 6 months. A mean steady-state serum concentration of 10 ng ml(-1) can be achieved in children after non-cardiac surgery in an intensive care unit with a morphine hydrochloride infusion of 5 micro g h(-1) kg(-1) at birth (term neonates), 8.5 micro g h(-1) kg(-1) at 1 month, 13.5 micro g h(-1) kg(-1) at 3 months and 18 micro g h(-1) kg(-1) at 1 year and 16 micro g h(-1) kg(-1) for 1- to 3-yr-old children

Small Packages, Big Returns: Uncovering the Venom Diversity of Small Inverebrate Conoidean Snails

Venomous organisms used in research were historically chosen based on size and availability. This opportunity-driven strategy created a species bias in which snakes, scorpions, and spiders became the primary subjects of venom research. Increasing technological advancements have enabled interdisciplinary studies using genomics, transcriptomics, and proteomics to expand venom investigation to animals that produce small amounts of venom or lack traditional venom producing organs. One group of non-traditional venomous organisms that have benefitted from the rise of -omic technologies is the Conoideans. The Conoidean superfamily of venomous marine snails includes, the Terebridae, Turridae (s.l), and Conidae. Conoidea venom is used for both predation and defense, and therefore under strong selection pressures. The need for conoidean venom peptides to be potent and specific to their molecular targets has made them important tools for investigating cellular physiology and bioactive compounds that are beneficial to improving human health. A convincing case for the potential of Conoidean venom is made with the first commercially available conoidean venom peptide drug Ziconotide (Prialt®), an analgesic derived from Conus magus venom that is used to treat chronic pain in HIV and cancer patients. Investigation of conoidean venom using -omics technology provides significant insights into predator-driven diversification in biodiversity and identifies novel compounds for manipulating cellular communication, especially as it pertains to disease and disorders

Parent-Metabolite Pharmacokinetic Models for Tramadol – Tests of Assumptions and Predictions

Allometric principles were used to discern cross-species differences in (±)-tramadol disposition and formation of its primary analgesic metabolite, (±)-O-desmethyl-tramadol (M1). Species differences in formation of M1 may help predict the analgesic effectiveness of tramadol. Tramadol was administered intravenously by a zero-order (constant infusion) process or rapid bolus dose and racemic concentrations of tramadol and M1 measured. Data were pooled to define differences between species (human, rat, cat, dog, goat, donkey and horse). A two-compartment linear disposition model with first-order elimination was used to describe tramadol and M1 disposition. Slow metabolizers were detected in 6% of the population and tramadol clearance to M1 was 16.2% that of extensive metabolizers. Tramadol clearance to M1 was slower and tramadol clearance by other pathways was faster in rats, dogs, and horses compared to humans. There are substantial differences between species in the pharmacokinetics of tramadol and its M1 metabolite, which are not explained by differences in body weight. The hypothesis that volumes of distribution are similar across species was shown not to be true. M1 exposure in the goat, donkey and cat was comparable to humans, which indicates it is likely to be an effective analgesic at typically used doses in these species but not in dogs or horses

A methodology to estimate net proton : phosphorus co-adsorption ratios for acidic soils

Despite extensive research, the behaviour of the key nutrient element, phosphorus (P), in soil is not yet fully understood. This study focussed on the outstanding issue of the co-adsorption of protons (H+ ) and P by soils. We developed a congruent set of measures to determine the net H+ :P co-adsorption ratio and tested it on goethite, for which a ratio of 1.6:1 had been estimated under CO2-free conditions for additions of NaH2PO4. Under our conditions, and using additions of KH2PO4, the net H+ :P co-adsorption ratio was estimated to be 1.44:1, i.e., in passable agreement with the published value. Application of the protocol to acidic soils resulted in a net H+ :P co-adsorption ratio of 1.92:1, and substitution of H3PO4 for KH2PO4 gave a ratio of 1.96:1. These ratios for soils differ significantly from that for goethite. The soils for which we estimated net H+ :P co-adsorption ratios had a wide range of properties and two had received previous applications of P fertiliser (Ca(H2PO4)2), which does not appear to have affected the net H+ :P co-adsorption ratios. The H+ :P co-adsorption ratio method could benefit from refinement, and further study is required to explore how these findings may apply to commercial P fertilisers under field conditions

Comment on "Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials".

Pharmacolog

Impurity effects on charge transport and magnetoconductance in a single layer poly(3-hexyl-thiophene) device

received: 2016-01-10 accepted: 2016-05-05 published: 2016-05-17The work was supported by the China Scholarship Council and Engineering (HG, SC, HL, TZ, JH), National Science Foundation of China, 61574095, and Physical Sciences Research Council Grant Nos. EP/J50029X/1, EP/K004484/1, and EP/L020114/1