Dark Matter signals from Draco and Willman 1: Prospects for MAGIC II and CTA

The next generation of ground-based Imaging Air Cherenkov Telescopes (IACTs) will play an important role in indirect dark matter searches. In this article, we consider two particularly promising candidate sources for dark matter annihilation signals, the nearby dwarf galaxies Draco and Willman 1, and study the prospects of detecting such a signal for the soon-operating MAGIC II telescope system as well as for the planned installation of CTA, taking special care of describing the experimental features that affect the detectional prospects. For the first time in such a study, we fully take into account the effect of internal bremsstrahlung, which has recently been shown to considerably enhance, in some cases, the gamma-ray flux at the high energies where Atmospheric Cherenkov Telescopes operate, thus leading to significantly harder annihilation spectra than traditionally considered. While the detection of the spectral features introduced by internal bremsstrahlung would constitute a smoking gun signature for dark matter annihilation, we find that for most models the overall flux still remains at a level that will be challenging to detect unless one adopts rather (though by no means overly) optimistic astrophysical assumptions about the distribution of dark matter in the dwarfs.Comment: 10 pages, 4 figures, minor changes, matches the published version (JCAP

Array tomography: Characterizing FAC-sorted populations of zebrafish immune cells by their 3D ultrastructure

For 3D reconstructions of whole immune cells from zebrafish, isolated from adult animals by FAC-sorting we employed array tomography on hundreds of serial sections deposited on silicon wafers. Image stacks were either recorded manually or automatically with the newly released ZEISS Atlas 5 Array Tomography platform on a Zeiss FEGSEM. To characterize different populations of immune cells, organelle inventories were created by segmenting individual cells. In addition, arrays were used for quantification of cell populations with respect to the various cell types they contained. The detection of immunological synapses in cocultures of cell populations from thymus or WKM with cancer cells helped to identify the cytotoxic nature of these cells. Our results demonstrate the practicality and benefit of AT for high-throughput ultrastructural imaging of substantial volumes. LAY DESCRIPTION: To look at immune cells from zebrafish we employed array tomography, a technique where arrays of serial sections deposited on solid substrates are used for imaging. Cell populations were isolated from the different organs of zebrafish involved in haematopoiesis, the production of blood cells. They were chemically fixed and centrifuged to concentrate them in a pellet that was then dehydrated and embedded in resin. Using a custom-built handling device it was possible to place hundreds of serial sections on silicon wafers as well ordered arrays. To image a whole cell at a resolution that would allow identifying all the organelles (i.e. compartments surrounded by membranes) inside the cell, stacks of usually 50–100 images were recorded in a scanning electron microscope (SEM). This recording was either done manually or automatically using the newly released Atlas Array Tomography platform on a ZEISS SEM. For the imaging of the sections a pixel size of about 5 nm was chosen, which defines membrane boundaries very well and allows segmentation of the membrane topology. After alignment of the images, cellular components were segmented to locate the individual organelles within the 3D reconstruction of the whole cell and also to create an inventory of organelles. Based on their morphologies we could identify specific cell types in the different hematopoietic organs. We could also quantify the proportion of each cell type in the whole population isolated from a given organ. Some of these specific cells from zebrafish were grown in a culture dish together with human cancer cells. By time-lapse light microscopy we observed that the fish cells attacked the cancer cells and killed them. From this we concluded that these cells must be similar to the cytotoxic cells from humans that play an important role in defence against spontaneously arising cancer cells in our bodies. They form special structures, called immunological synapses that we could also identify on our arrays and reconstruct in 3D. This is the first time the potential of zebrafish immune cells to form immunological synapses has been demonstrated. Our study is a good example for the practicality and benefit of array tomography in high-throughput ultrastructure imaging of substantial volumes, applicable to many areas of cell and developmental biology

Quintessence from Shape Moduli

We show that shape moduli in sub-millimeter extra dimensional scenarios, addressing the gauge hierarchy problem, can dominate the energy density of the universe today. In our scenario, the volume of the extra dimensions is stabilized at a sufficiently high scale to avoid conflicts with nucleosynthesis and solar-system precision gravity experiments, while the shape moduli remain light but couple extremely weakly to brane-localized matter and easily avoid these bounds. Nonlocal effects in the bulk of the extra dimension generate a potential for the shape moduli. The potential has the right form and order of magnitude to account for the present day cosmic acceleration, in a way analogous to models of quintessence as a pseudo Nambu-Goldstone boson.Comment: 8 pages, 1 figur

Multi-wavelength interferometry of evolved stars using VLTI and VLBA

We report on our project of coordinated VLTI/VLBA observations of the atmospheres and circumstellar environments of evolved stars. We illustrate in general the potential of interferometric measurements to study stellar atmospheres and envelopes, and demonstrate in particular the advantages of a coordinated multi-wavelength approach including near/mid-infrared as well as radio interferometry. We have so far made use of VLTI observations of the near- and mid-infrared stellar sizes and of concurrent VLBA observations of the SiO maser emission. To date, this project includes studies of the Mira stars S Ori and RR Aql as well as of the supergiant AH Sco. These sources all show strong silicate emission features in their mid-infrared spectra. In addition, they each have relatively strong SiO maser emission. The results from our first epochs of S Ori measurements have recently been published and the main results are reviewed here. The S Ori maser ring is found to lie at a mean distance of about 2 stellar radii, a result that is virtually free of the usual uncertainty inherent in comparing observations of variable stars widely separated in time and stellar phase. We discuss the status of our more recent S Ori, RR Aql, and AH Sco observations, and present an outlook on the continuation of our project.Comment: 9 pages, to appear in the proceedings of the ESO workshop "The Power of Optical/IR Interferometry: Recent Scientific Results and 2nd Generation VLTI Instrumentation", ESO Astrophysics Symposi

Development and Validation of a Tokamak Skin Effect Transformer model

A control oriented, lumped parameter model for the tokamak transformer including the slow flux penetration in the plasma (skin effect transformer model) is presented. The model does not require detailed or explicit information about plasma profiles or geometry. Instead, this information is lumped in system variables, parameters and inputs. The model has an exact mathematical structure built from energy and flux conservation theorems, predicting the evolution and non linear interaction of the plasma current and internal inductance as functions of the primary coil currents, plasma resistance, non-inductive current drive and the loop voltage at a specific location inside the plasma (equilibrium loop voltage). Loop voltage profile in the plasma is substituted by a three-point discretization, and ordinary differential equations are used to predict the equilibrium loop voltage as function of the boundary and resistive loop voltages. This provides a model for equilibrium loop voltage evolution, which is reminiscent of the skin effect. The order and parameters of this differential equation are determined empirically using system identification techniques. Fast plasma current modulation experiments with Random Binary Signals (RBS) have been conducted in the TCV tokamak to generate the required data for the analysis. Plasma current was modulated in Ohmic conditions between 200kA and 300kA with 30ms rise time, several times faster than its time constant L/R\approx200ms. The model explains the most salient features of the plasma current transients without requiring detailed or explicit information about resistivity profiles. This proves that lumped parameter modeling approach can be used to predict the time evolution of bulk plasma properties such as plasma inductance or current with reasonable accuracy; at least in Ohmic conditions without external heating and current drive sources

Nucleon charge exchange on the deuteron: A critical review

The existing experimental data on the d(n,p)nn and d(p,n)pp cross sections in the forward direction are reviewed in terms of the Dean sum rule. It is shown that the measurement of the ratio of the charge exchange on the deuteron to that on the proton might, if taken together with other experimental data, allow a direct construction of the np -> np scattering amplitude in the backward direction with few ambiguities.Comment: 7 pages with 3 figure

Characterization of optical properties and surface roughness profiles: The Casimir force between real materials

The Lifshitz theory provides a method to calculate the Casimir force between two flat plates if the frequency dependent dielectric function of the plates is known. In reality any plate is rough and its optical properties are known only to some degree. For high precision experiments the plates must be carefully characterized otherwise the experimental result cannot be compared with the theory or with other experiments. In this chapter we explain why optical properties of interacting materials are important for the Casimir force, how they can be measured, and how one can calculate the force using these properties. The surface roughness can be characterized, for example, with the atomic force microscope images. We introduce the main characteristics of a rough surface that can be extracted from these images, and explain how one can use them to calculate the roughness correction to the force. At small separations this correction becomes large as our experiments show. Finally we discuss the distance upon contact separating two rough surfaces, and explain the importance of this parameter for determination of the absolute separation between bodies.}Comment: 33 pages, 14 figures, to appear in Springer Lecture Notes in Physics, Volume on Casimir Physics, edited by Diego Dalvit, Peter Milonni, David Roberts, and Felipe da Ros