Pre-Practice Hydration Status of Collegiate Male American Football Players with Sickle Cell Trait

Since 2000, 63% of deaths associated with college football were due to complications, such as sickling events; however, sickle cell trait (SCT) only affects 3-4% of participating athletes. Sickling events can be exasperated by conditions, including heat exposure, dehydration, and intense physical activity and lead to rhabdomyolysis and death. Assessing hydration status is crucial for athletes and the use of urine specific gravity (USG) has been shown to provide rapid and valid results. The purpose of this study was to assess the prevalence of dehydration among SCT carrying American college football players. Division I collegiate football athletes participated as part of a larger study. Athletes provided a midstream urine sample, for USG assessment, each morning for three days of fall football camp during August 2021. Cut offs for USG were as follows: well-hydrated (\u3c1.010), minimal dehydration (1.011-1.020), significant dehydration (1.021-1.030), severe hypohydration (\u3e1.030). USG measurements evaluated a correlation between SCT and hydration status along with an association between SCT and hydration level. The data showed a strong, significant correlation for day 1 (r=0.78, p=0.001), a moderate, significant correlation for day 2 (r=0.56, p=0.045), and a moderate correlation for day 3 (r=0.41, p=0.128). The data did not show a significant association between SCT and hydration level for any of the days. These findings suggest that there is a need for increased education for both sports medicine practitioners and athletes to maintain proper hydration for SCT athletes

Drug and Nutrient Interactions

This book is intended to pursue questions at the intersection nutritional sciences and pharmacology. A 2013 Mayo Clinic survey estimates that 7 out of 10 Americans are on at least one prescription drug, and more than half take two. Despite prominent use of prescription medications, issues related to nutrition because of prescription use – and vice versa – how nutrition can affect drug action – are not typically explored. Section I introduces readers to pharmacology terms and concepts related to drug and nutrient interactions. Mechanisms underlying drug and nutrient interactions with drug administration, absorption, distribution, metabolism and excretion are also described. Section II describes the impact of drugs on nutrient status and conversely, the effect of nutrient status/nutrition on pharmacotherapy. Section III considers the role of the Food and Drug Administration (FDA) on foods versus drugs, and the regulatory framework underlying pharmaceuticals, dietary supplements, foods and food products

Factors associated with retention in Option B+ in Malawi: a case control study.

IntroductionThere are limited data on factors associated with retention in Option B+. We sought to explore the characteristics of women retained in Option B+ in Malawi, with a focus on the role of HIV disclosure, awareness of partner HIV status, and knowledge around the importance of Option B+ for maternal-child health. Methods We performed a case-control study of HIV-infected women in Malawi initiated on antiretroviral therapy (ART) under Option B+. Cases were enrolled if they met criteria for default from Option B+ (out of ART for >60 days), and controls were enrolled in approximately 3:1 ratio if they were retained in care for at least 12 months. We surveyed socio-demographic characteristics, HIV disclosure and awareness of partner HIV status, self-report about receiving pre-ART education, and knowledge of Option B+. Univariate logistic regression was performed to determine factors associated with retention. Multivariate logistic regression model was used to evaluate the relationship between HIV disclosure, Option B+ knowledge, and retention after adjusting for age, schooling, and travel time to clinic.ResultsWe enrolled 50 cases and 153 controls. Median age was 30 years (interquartile range (IQR) 25-34), and the majority (82%) initiated ART during pregnancy at a median gestational age of 24 weeks (IQR 16-28). Ninety-one per cent of the cases (39/43) who started ART during pregnancy defaulted by three months postpartum. HIV disclosure to the primary sex partner was more common among women retained in care (100% versus 78%, p < 0.001). Odds of retention were significantly higher among women with: age >25 years (odds ratio (OR) 2.44), completion of primary school (OR 3.06), awareness of partner HIV status (OR 5.20), pre-ART education (OR 6.17), higher number of correct answers to Option B+ knowledge questions (OR 1.82), and support while taking ART (OR 3.65). Pre-ART education and knowledge were significantly correlated (r = 0.43, p < 0.001). In multivariate analysis, awareness of partner HIV status (OR 4.07, 95% confidence interval (CI) 1.51-10.94, p = 0.02) and Option B+ knowledge (OR 1.60, 95% CI 1.15-2.23, p = 0.004) remained associated with retention.ConclusionsInterventions that address partner disclosure and strengthen pre-ART education around the benefits of ART for maternal and child health should be evaluated to improve retention in Malawi's Option B+ programme

Defining the Value of Libraries: Trends in Academic Library Assessment

Just like other academic areas on campus, academic libraries frequently engage in assessment. In this panel, a group of esteemed leaders of library assessment will discuss ways in which libraries are assessing their impact on higher education. Librarians have a long history of evaluating their collections. Yet in the face of seismic change in the technological and educational landscapes, assessment trends in libraries now extend to robust programs of evaluating student learning, assessing the impact of library services and spaces, and demonstrating how libraries are a vital part of achieving institutional goals. Attendees will gain an understanding of assessing beyond direct academic outcomes, learn how library initiatives may be an opportunity to collaborate on common goals, and how libraries demonstrate their value in a campus-wide context

REFRAMING CULTURAL COMPETENCE AND CIVIC ENGAGEMENT: A REPLICATION STUDY OF HIGH IMPACT PRACTICES IN UNDERGRADUATE PSYCHOLOGY COURSES

Institutions of higher education require diversity courses so that students can increase their multicultural awareness, knowledge, and skills. Multicultural Psychology courses play a pivotal role in instilling cultural competence in students. The study examined differences in cultural competence and civic engagement for 1,053 undergraduate students exposed to different types of high-impact practices enrolled in educational psychology, multicultural psychology, and psychology internship courses. There was a significant Group x Time interaction effect for cultural skills. Post hoc analyses revealed that students exposed to diversity service-learning in a multicultural psychology course acquired cultural skills compared to students exposed to academic service-learning in the educational psychology course and those students exposed to fieldwork in an internship from the beginning to the end of the semester. Students in the multicultural psychology course were also intellectually challenged, reflected on the course concepts, and gained a deeper understanding of the course content more than students in the educational psychology course. Recommendations for teaching diversity courses are discussed.  Article visualizations

A Reference Section for the Otavi Group (Damara Supergroup) in Eastern Kaoko Zone near Ongongo, Namibia

A reference section for the Otavi Group (Damara Supergroup) in the East Kaoko Zone near Ongongo is proposed and described. The section is easily accessible, well exposed, suitable for field excursions, and well documented in terms of carbonate lithofacies, depositional sequences and stableisotope chemostratigraphy. The late Tonian Ombombo Subgroup is 355 m thick above the basal Beesvlakte Formation, which is not included in the section due to poor outcrop and complex structure. The earlymiddle Cryogenian Abenab Subgroup is 636 m thick and the early Ediacaran Tsumeb Subgroup is 1020 m thick. While the section is complete in terms of formations represented, the Ombombo and lower Abenab subgroups have defined gaps due to intermittent uplift of the northward-sloping Makalani rift shoulder. The upper Abenab and Tsumeb subgroups are relatively thin due to erosion of a broad shallow trough during late Cryogenian glaciation and flexural arching during post-rift thermal subsidence of the carbonate platform

Hemorrhage-induced intestinal damage is complement independent in Helicobacter hepaticus infected mice

With over half of the world population infected, Helicobacter infection is an important public health issue associated with gastrointestinal cancers and inflammatory bowel disease. Animal studies indicate that complement and oxidative stress play a role in Helicobacter infections. Hemorrhage induces tissue damage which is attenuated by blockade of either complement activation or oxidative stress products. Therefore, we hypothesized that chronic Helicobacter hepaticus infection would modulate hemorrhage-induced intestinal damage and inflammation. To test this hypothesis, we examined hemorrhage-induced jejunal damage and inflammation in uninfected and H. hepaticus infected mice. H. hepaticus infection increased hemorrhage-induced mid-jejunal mucosal damage despite attenuating complement activation. In addition, infection alone increased chemokine secretion, changing the hemorrhage-induced neutrophil infiltration to a macrophage-mediated inflammatory response. The hemorrhage-induced macrophage infiltration correlated with increased secretion of tumor necrosis factor-α (TNF-α³) and nitric oxide (NO) in the infected mice. Together these data indicate that Helicobacter infection modulates the mechanism of hemorrhage-induced intestinal damage and inflammation from a complement-mediated response to a macrophage response with elevated TNF-α and NO. These data indicate that chronic, low level infections change the response to trauma and should be considered when designing and administering therapeutics

Making & Sustaining Change from Psychotherapy: A Mixed Method Study

This mixed method study explored both (1) how changes are made and (2) what encourages the maintenance of change after psychotherapy. Literature has called for further exploration into what helps clients to make and sustain change from their perspectives. While the effectiveness of approaches such as: psychodynamic, cognitive behavioral, and other disorder-specific treatments has been demonstrated broadly, less is known about individual variables, and specifically about how individuals participate in and support their recovery. This study used a mixed method sequential design. Wampold & Imel’s (2015) contextual model was used as a conceptual framework throughout the study. Using secondary data analysis, we used quantitative methods to explore the degree to which clients made and maintained progress using an empirical measure: the OQ-45.2 (using a longitudinal, within subjects design). Fourteen (N = 14) qualitative interviews were reviewed to hear from a sample of former clients about their impressions of what supported their efforts at change and how they maintained these gains 12–18 months post treatment. The findings of the quantitative strand demonstrated clinically meaningful change from pretest to posttest, posttest to follow-up, and from pretest to follow-up with an effect size of d = .5. Qualitative themes emerged within five categories used to describe the findings. These categories included questions asking about: (1) what drives or facilitates change, (2) what participants do to maintain change post-therapy, and (3) what was and was not helpful in their therapy experiences. The findings suggest implications for both practice and policy. Practice implications include the importance of both monitoring client progress and of termination as a distinct phases of therapeutic relationships. Policy implications include the importance of economic and other macro-level variables in supporting or discouraging mental health