22 research outputs found
Achiral Ligands Dramatically Enhance Rate and Enantioselectivity in the Rh/Phosphoramidite-Catalyzed Hydrogenation of α,β-Disubstituted Unsaturated Acids
CBM-14GLIOBLASTOMA CELLS EXPOSED TO 5-ALA RELEASE PROTOPORPHYRIN IX CONTAINING EXTRACELLULAR VESICLES DETECTABLE BY HIGH-RESOLUTION FLOW CYTOMETRY
Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses
Maternal milk is nature's first functional food. It plays a crucial role in the development of the infant's gastrointestinal (GI) tract and the immune system. Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer enclosed vesicles released by cells for intercellular communication and are a component of milk. Recently, we discovered that human milk EVs contain a unique proteome compared to other milk components. Here, we show that physiological concentrations of milk EVs support epithelial barrier function by increasing cell migration via the p38 MAPK pathway. Additionally, milk EVs inhibit agonist-induced activation of endosomal Toll like receptors TLR3 and TLR9. Furthermore, milk EVs directly inhibit activation of CD4+ T cells by temporarily suppressing T cell activation without inducing tolerance. We show that milk EV proteins target key hotspots of signalling networks that can modulate cellular processes in various cell types of the GI tract
Anxiety and depression scores in patients with coronary artery disease and coronary artery ectasia
Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics
Figure_e-8_HDL_feature_plots_for_all_individual_cohorts
Figure e-8: HDL feature plots for all individual cohorts
Table_e-4_Meta_analysis_results_of_the_logistic_regression
Table e-4: Meta-analysis results of the logistic regressions with sex, age, and metabolite concentrations as independent variables and migraine status as dependent variable
Figure_e-7_Metabolite_correlation_between_measurements_and_over_time
Figure e-7: Metabolite correlations between measurements and over time for apoA1 and the S-HDL-FC ratio
Figure_e-5_Ratio_stratification_plots_migraine_depression
Figure e-5: ApoA1 and S-HDL-FC ratio stratification plots for migraine and depression in NESDA and LUMINA