Feasibility of imaging using Boltzmann polarization in nuclear Magnetic Resonance Force Microscopy

We report on Magnetic Resonance Force Microscopy measurements of the Boltzmann polarization of the nuclear spins in copper by detecting the frequency shift of a soft cantilever. We use the time-dependent solution of the Bloch equations to derive a concise equation describing the effect of rf magnetic fields on both on- and off-resonant spins in high magnetic field gradients. We then apply this theory to saturation experiments performed on a 100 nm thick layer of copper, where we use the higher modes of the cantilever as source of the rf field. We demonstrate a detection volume sensitivity of only (40 nm)$^3$, corresponding to about 1.6$\cdot 10^4$ polarized copper nuclear spins. We propose an experiment on protons where, with the appropriate technical improvements, frequency-shift based magnetic resonance imaging with a resolution better than (10 nm)$^3$ could be possible. Achieving this resolution would make imaging based on the Boltzmann polarization competitive with the more traditional stochastic spin-fluctuation based imaging, with the possibility to work at milliKelvin temperatures

Bond of Reinforcement Cable in 3D Printed Concrete

The use of high strength steel cables directly entrained into printed concrete during the printing process, has previously been introduced as a method to provide reinforcement to objects being manufactured through a layer-extrusion based 3D concrete printing process. The bond between the cable and the cementitious mortar is a crucial parameter for the structural performance of such reinforcement, and was hence subject of a detailed study presented in this paper. The bond performance was studied in direct and flexural pull-out tests on cast and printed specimens and further analyzed by microscopic analysis of the bond surface. Two effects were identified that significantly decrease the bond strength. Firstly, chemical reactions create a spongy interface of poor strength. Secondly, the flow of mortar around the cable tends to create a cavity underneath the cable which reduces the effective bond surface. Mortar viscosity, nozzle design and filament pressure, were thus identified as important parameters for the bond quality. The average bond quality seems to reduce with embedment length. As a consequence, cable breakage was not achieved, in spite of considerable embedment lengths that were tested. Likely, this was caused by the cumulative probability of critical defects along the increasing embedment length, in combination with a non-constant shear distribution. All test series showed significant scatter. It was concluded that, although this reinforcement method is promising as it can potentially provide sufficient post-cracking strength, the bond quality must be improved considerably both in terms of average strength and reduction of scatter

Acute coronary syndromes: considerations for improved acceptance and implementation of management guidelines.

The management of acute coronary syndrome in Europe is covered by various European Society of Cardiology guidelines, which although valuable, are complex and may not always provide clear guidance in everyday clinical practice. Consequently, implementation of the guideline recommendations is frequently suboptimal. To complicate matters further, a wealth of new data from large trials examining novel anti-thrombotic agents will become or are already available, necessitating guideline updates. This article summarizes the gaps between current guideline-recommended treatment of acute coronary syndrome and daily practice as dictated by the evidence base, including recent trials. Reasons for the suboptimal implementation of the current European Society of Cardiology guidelines and possible solutions to making these more practice oriented are presented