244 research outputs found
Eva Strittmatter: Heliotrop. Gedichte
Berlin and Weimar: Aufbau, 1983. 127 p., M 7,60
Erwin Strittmatter: Selbstermunterungen
Berlin and Weimar: Aufbau, 1981. (Edition Neue Texte), 122 p., 4,50 M
Adjuvant Radiotherapy in Patients with Squamous Cell Carcinoma of the Oral Cavity or Oropharynx and Solitary Ipsilateral Lymph Node Metastasis (pN1) : A Prospective Multicentric Cohort Study
(1) Background: Evaluation of impact of adjuvant radiation therapy (RT) in patients with
oral squamous cell carcinoma of the oral cavity/oropharynx (OSCC) of up to 4 cm (pT1/pT2) and
solitary ipsilateral lymph node metastasis (pN1). A non-irradiated group with clinical follow-up was
chosen for control, and survival and quality of life (QL) were compared; (2) Methods: This prospective
multicentric comprehensive cohort study included patients with resected OSCC (pT1/pT2, pN1,
and cM0) who were allocated into adjuvant radiation therapy (RT) or observation. The primary
endpoint was overall survival. Secondary endpoints were progression-free survival and QL after
surgery; (3) Results: Out of 27 centers, 209 patients were enrolled with a median follow-up of 3.4 years.
An amount of 137 patients were in the observation arm, and 72 received adjuvant irradiation. Overall
survival did not differ between groups (hazard ratio (HR) 0.98 [0.55–1.73], p = 0.94). There were fewer
neck metastases (HR 0.34 [0.15–0.77]; p = 0.01), as well as fewer local recurrences (HR 0.41 [0.19–0.89];
p = 0.02) under adjuvant RT. For QL, irradiated patients showed higher values for the symptom scale
pain after 0.5, two, and three years (all p < 0.05). After six months and three years, irradiated patients
reported higher symptom burdens (impaired swallowing, speech, as well as teeth-related problems
(all p < 0.05)). Patients in the RT group had significantly more problems with mouth opening after
six months, one, and two years (p < 0.05); (4) Conclusions: Adjuvant RT in patients with early SCC of
the oral cavity and oropharynx does not seem to influence overall survival, but it positively affects
progression-free survival. However, irradiated patients report a significantly decreased QL up to
three years after therapy compared to the observation group
DNA hybridization kinetics: zippering, internal displacement and sequence dependence
Although the thermodynamics of DNA hybridization is generally well established, the kinetics of this classic transition is less well understood. Providing such understanding has new urgency because DNA nanotechnology often depends critically on binding rates. Here, we explore DNA oligomer hybridization kinetics using a coarse-grained model. Strand association proceeds through a complex set of intermediate states, with successful binding events initiated by a few metastable base-pairing interactions, followed by zippering of the remaining bonds. But despite reasonably strong interstrand interactions, initial contacts frequently dissociate because typical configurations in which they form differ from typical states of similar enthalpy in the double-stranded equilibrium ensemble. Initial contacts must be stabilized by two or three base pairs before full zippering is likely, resulting in negative effective activation enthalpies. Non-Arrhenius behavior arises because the number of base pairs required for nucleation increases with temperature. In addition, we observe two alternative pathways—pseudoknot and inchworm internal displacement—through which misaligned duplexes can rearrange to form duplexes. These pathways accelerate hybridization. Our results explain why experimentally observed association rates of GC-rich oligomers are higher than rates of AT- rich equivalents, and more generally demonstrate how association rates can be modulated by sequence choice
Michael Franz: TausendfuĂź und Hunderthand. Gedichte
Halle/Leipzig: Mitteldeutscher Verlag, 1979. 87 p., 5,- M
- …