94 research outputs found
Public Perceptions of Values Associated with Wildfire Protection at the Wildland-Urban Interface: A Synthesis of National Findings
The wildland-urban interface (WUI) continues to transform rural landscapes as previously undeveloped areas are populated with residential and commercial structures which, in turn, impact ecosystems and create landscapes of risk. Within this context, the science of wildfire risk mitigation has experienced renewed and enhanced support among scientists and managers. However, risk mitigation measures have not found purchase in either the public’s acceptance or involvement in this new role of and for fire. This may partially result from little regard for the effects of wildfire prevention efforts on values other than protecting homes and other structures. We report findings from qualitative interviews conducted across the United States to identify and define various values at risk from wildfire. Values influencing risk mitigation emerged from the biophysical, sociodemographic, and sociocultural contexts of wildfire. Findings demonstrate how wildfire is intertwined with diverse sets of risks experienced in daily life. We provide a discussion of how this research impacts the transformation of landscapes and risk management strategies. Identifying and better understanding the effects of values associated with wildfire—and landscape change in the WUI—will allow natural resource managers and decision makers to develop more effective fuel treatment programs and land use policies
Water Footprint and Life Cycle Assessment as approaches to assess potential impacts of products on water consumption: Key learning points from pilot studies on tea and margarine
Water accounting and environmental impact assessment across the product's life cycle is gaining prominence. This paper presents two case studies of applying the Life Cycle Assessment (LCA) and Water Footprint (WF) approaches to tea and margarine. The WF, excluding grey water, of a carton of 50 g tea is 294 L green water and 10 L blue water, and that of a 500 g tub of margarine is 553 L green water, 109 L blue water. The inventory results in the LCA studies (blue water) are 13 L for tea and 114 L for margarine. In the impact assessment phase of WF, Coonoor in Southern India appears as a potential hotspot for tea production, although the water consumed in energy to boil the kettle and by the consumer are also significant. For margarine the main potential hotspot is irrigated sunflower around Zaporizhia in Ukraine. The impact assessment results of LCA for tea causes the water in the consumer use phase to be down-weighted and stresses the contribution from Coonoor due to the higher water scarcity of this region. Similarly the LCA impact assessment of margarine causes the palm oil contribution to be down-weighted due to the low water scarcity of Medan in Indonesia. From these case studies we identify similarities, differences and synergies at both the water accounting and impact assessment levels for both approaches with the purpose of improving and advancing the water resource assessment process
Strongly focused light beams interacting with single atoms in free space
We construct 3-D solutions of Maxwell's equations that describe Gaussian
light beams focused by a strong lens. We investigate the interaction of such
beams with single atoms in free space and the interplay between angular and
quantum properties of the scattered radiation. We compare the exact results
with those obtained with paraxial light beams and from a standard input-output
formalism. We put our results in the context of quantum information processing
with single atoms.Comment: 9 pages, 9 figure
Development of a tight-binding potential for bcc-Zr. Application to the study of vibrational properties
We present a tight-binding potential based on the moment expansion of the
density of states, which includes up to the fifth moment. The potential is
fitted to bcc and hcp Zr and it is applied to the computation of vibrational
properties of bcc-Zr. In particular, we compute the isothermal elastic
constants in the temperature range 1200K < T < 2000K by means of standard Monte
Carlo simulation techniques. The agreement with experimental results is
satisfactory, especially in the case of the stability of the lattice with
respect to the shear associated with C'. However, the temperature decrease of
the Cauchy pressure is not reproduced. The T=0K phonon frequencies of bcc-Zr
are also computed. The potential predicts several instabilities of the bcc
structure, and a crossing of the longitudinal and transverse modes in the (001)
direction. This is in agreement with recent ab initio calculations in Sc, Ti,
Hf, and La.Comment: 14 pages, 6 tables, 4 figures, revtex; the kinetic term of the
isothermal elastic constants has been corrected (Eq. (4.1), Table VI and
Figure 4
Relativistic transition wavelenghts and probabilities for spectral lines of Ne II
Transition wavelengths and probabilities for several 2p4 3p - 2p4 3s and 2p4
3d - 2p4 3p lines in fuorine-like neon ion (NeII) have been calculated within
the multiconfiguration Dirac-Fock (MCDF) method with quantum electrodynamics
(QED) corrections. The results are compared with all existing experimental and
theoretical data
A review of spatial causal inference methods for environmental and epidemiological applications
The scientific rigor and computational methods of causal inference have had
great impacts on many disciplines, but have only recently begun to take hold in
spatial applications. Spatial casual inference poses analytic challenges due to
complex correlation structures and interference between the treatment at one
location and the outcomes at others. In this paper, we review the current
literature on spatial causal inference and identify areas of future work. We
first discuss methods that exploit spatial structure to account for unmeasured
confounding variables. We then discuss causal analysis in the presence of
spatial interference including several common assumptions used to reduce the
complexity of the interference patterns under consideration. These methods are
extended to the spatiotemporal case where we compare and contrast the potential
outcomes framework with Granger causality, and to geostatistical analyses
involving spatial random fields of treatments and responses. The methods are
introduced in the context of observational environmental and epidemiological
studies, and are compared using both a simulation study and analysis of the
effect of ambient air pollution on COVID-19 mortality rate. Code to implement
many of the methods using the popular Bayesian software OpenBUGS is provided
Age at symptom onset and death and disease duration in genetic frontotemporal dementia : an international retrospective cohort study
Background: Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. Methods: In this international, retrospective cohort study, we collected data on age at symptom onset, age at death, and disease duration for patients with pathogenic mutations in the GRN and MAPT genes and pathological expansions in the C9orf72 gene through the Frontotemporal Dementia Prevention Initiative and from published papers. We used mixed effects models to explore differences in age at onset, age at death, and disease duration between genetic groups and individual mutations. We also assessed correlations between the age at onset and at death of each individual and the age at onset and at death of their parents and the mean age at onset and at death of their family members. Lastly, we used mixed effects models to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried. Findings: Data were available from 3403 individuals from 1492 families: 1433 with C9orf72 expansions (755 families), 1179 with GRN mutations (483 families, 130 different mutations), and 791 with MAPT mutations (254 families, 67 different mutations). Mean age at symptom onset and at death was 49\ub75 years (SD 10\ub70; onset) and 58\ub75 years (11\ub73; death) in the MAPT group, 58\ub72 years (9\ub78; onset) and 65\ub73 years (10\ub79; death) in the C9orf72 group, and 61\ub73 years (8\ub78; onset) and 68\ub78 years (9\ub77; death) in the GRN group. Mean disease duration was 6\ub74 years (SD 4\ub79) in the C9orf72 group, 7\ub71 years (3\ub79) in the GRN group, and 9\ub73 years (6\ub74) in the MAPT group. Individual age at onset and at death was significantly correlated with both parental age at onset and at death and with mean family age at onset and at death in all three groups, with a stronger correlation observed in the MAPT group (r=0\ub745 between individual and parental age at onset, r=0\ub763 between individual and mean family age at onset, r=0\ub758 between individual and parental age at death, and r=0\ub769 between individual and mean family age at death) than in either the C9orf72 group (r=0\ub732 individual and parental age at onset, r=0\ub736 individual and mean family age at onset, r=0\ub738 individual and parental age at death, and r=0\ub740 individual and mean family age at death) or the GRN group (r=0\ub722 individual and parental age at onset, r=0\ub718 individual and mean family age at onset, r=0\ub722 individual and parental age at death, and r=0\ub732 individual and mean family age at death). Modelling showed that the variability in age at onset and at death in the MAPT group was explained partly by the specific mutation (48%, 95% CI 35\u201362, for age at onset; 61%, 47\u201373, for age at death), and even more by family membership (66%, 56\u201375, for age at onset; 74%, 65\u201382, for age at death). In the GRN group, only 2% (0\u201310) of the variability of age at onset and 9% (3\u201321) of that of age of death was explained by the specific mutation, whereas 14% (9\u201322) of the variability of age at onset and 20% (12\u201330) of that of age at death was explained by family membership. In the C9orf72 group, family membership explained 17% (11\u201326) of the variability of age at onset and 19% (12\u201329) of that of age at death. Interpretation: Our study showed that age at symptom onset and at death of people with genetic frontotemporal dementia is influenced by genetic group and, particularly for MAPT mutations, by the specific mutation carried and by family membership. Although estimation of age at onset will be an important factor in future pre-symptomatic therapeutic trials for all three genetic groups, our study suggests that data from other members of the family will be particularly helpful only for individuals with MAPT mutations. Further work in identifying both genetic and environmental factors that modify phenotype in all groups will be important to improve such estimates. Funding: UK Medical Research Council, National Institute for Health Research, and Alzheimer's Society
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
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