Smart electric vehicle charging strategies for sectoral coupling in a city energy system

The decarbonization of city energy systems plays an important role to meet climate targets. We examine the consequences of integrating electric cars and buses into the city energy system (60% of private cars and 100% of public buses), using three different charging strategies in a modelling tool that considers local generation and storage of electricity and heat, electricity import to the city, and investments to achieve net-zero emissions from local electricity and heating in 2050. We find that up to 85% of the demand for the charging of electric cars is flexible and that smart charging strategies can facilitate 62% solar PV in the charging electricity mix, compared to 24% when cars are charged directly when parked. Electric buses are less flexible, but the timing of charging enables up to 32% to be supplied by solar PV. The benefit from smart charging to the city energy system can be exploited when charging is aligned with the local value of electricity in the city. Smart charging for cars reduces the need for investments in stationary batteries and peak units in the city electricity and heating sectors. Thus, our results point to the importance of sectoral coupling to exploit flexibility options in the city electricity, district heating and transport sectors

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely