Income-carbon Emissions Nexus for Middle East and North Africa Countries: A Semi-parametric Approach

It is widely accepted that MENA region is significantly impacted by climate change. Evidence suggests that the region is positioned at the second place after North America in carbon emission. This study attempts to further examine the impacts of income on carbon emissions in MENA region through investigation of the existence of an environmental Kuznets curve (EKC). Within the Stochastic Impacts by Regression on Population, Affluence and Technology (STIRPAT) framework, this is the first study in MENA region to explore the income-carbon emissions nexus; using panel data together with a semi-parametric panel fixed effects regression. Our data set is referred to a panel of 20 countries in MENA region spanning the period 1980 - 2014. With this information, we find evidence to support an inverted-U shaped relationship between income and CO2 emissions in the region. These findings suggest that environmental degradation may be reversible and environmental quality may be recoverable alongside the economic growth process in the region. Keywords: Per capita income, carbon emissions, STIRPAT environmental Kuznets curve, MENA region. JEL Classifications: Q01, Q28, Q52, Q51

Texture evaluation of whey protein concentrate incorporated ice cream by Back Extrusion technique

Back extrusion technique was employed to evaluated texture properties of partial substituted whey protein concentrate (WPC) with milk solids not fat (1, 2, 3 and 4%) in ice cream formula. There was no remarkable effect of adding WPC on total solids or fat %. Total protein increased, while ash, and lactose content were significantly decreased. Back-extrusion results represented a decrease in hardness values of resultant ice cream, while, during storage, there was a slight increase. Energy input values decreased by increasing substitution levels of WP. Although, energy output inversely correlated with substitution levels of WP it correlated with storage period indicating a strong structure for stored ice cream. Load at target deformation (50%) applied to the samples when fresh and after 14 days storage showing decreased values proportional to increasing substitution levels of WP. The resilience showed decreased ratio indicating more visco-elastic properties in fresh ice cream. The recovered height and deformation increased with increasing substitution levels of WP and storage period. Therefore, more sticking properties were obtained in resultant ice cream. Adhesive force decreased significantly with increasing substitution levels of WP and storage period. Adhesiveness values were significantly higher in all treatments than control. The texture of the ice cream became smoother by replacing milk solid not fat with WPC up to 3%. From the data obtained, it could be recommended that ice cream can be produced with high quality by substituting milk solid not fat with WPC up to 3%

Prevalence of Comorbidities Associated With Type 2 Diabetes Mellitus In Ksa: A Cross-Sectional Study

Objective: To determine the prevalence of comorbidities associated with type 2 diabetes mellitus among the Saudi adult population. Methods: A cross-sectional study design will be employed to investigate the prevalence of comorbidities associated with Type 2 Diabetes Mellitus (T2DM) within the Kingdom of Saudi Arabia (KSA) population. This design allows for the collection of data at a single point in time, providing insights into the existing relationship between T2DM and comorbidities.Results: The study included 601 participants. The most frequent body mass index BMI value among study participants was overweight 25-29.9 kg/m2 (n= 196, 33%), followed by Normal 18.5-24.9 kg/m2 (n= 177, 29%). The frequent gender among study participants was male years (n= 356, 59%) and female (n= 245, 41%). The most frequent age among study participants was 40-50 years (n= 145, 24%), followed by 18-28 years (n= 140, 23%). The most frequent marital status among study participants was married (n= 360, 60%), followed by single (n= 160, 27%). The perceived physical activity per week among study participants, most of whom did not do any activity (n=231,38%) followed one-time activity (n=98,16%). Conclusion: The results showed that most of the study participants were overweight according to their BMI. The majority of patients had normal blood pressure. Most of the participants suffer from diabetes. In addition, most of the participants do not do any activity, and the majority of participants are non-smokers

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Cloning, Expression and Regulation of HAS-MIRS On their Target MRNAS

MicroRNA\u27s (miRNAs) are short non-coding RNAs of 18-24 nucleotides. They regulate gene expression in unicellular and multicellular organisms at the posttranscription level by preventing translation and promote degradation of mRNAs. A single miRNA regulates multiple mRNAs. They govern multiple genes expression at the cellular level through cell proliferation, cell differentiation and apoptosis, and they have been implicated in many diseases such as cancer, cardiovascular, and neurodegenerative diseases. Many of the mRNAs that are targeted by miRNAs are identified by computational analysis and their functions are yet to be validated. The objective of this study is to verify the predicted mRNA targets ofhsa-miR-4259 and hsa-miR-200b; and to confirm that hsa-miR-4259 down-regulates expression ofUBF1 and NFKB2; and hsamiR- 200b down-regulates expression ofMBNL1 and MBNL3 in PC3 cells. We successfully cloned pre-hsa-miR-4259 into pmR-ZsGreen1 expression vector (i.e. GFP), creating pre-hsa-miR-4259-pmR-ZsGreen1 DNA construct, as well as overexpression of the DNA construct in PC3 cells. The result also confirmed the predicted information that 1 2 is available at the miRDB, which predicts that hsa-miR-4259 targets UBFl and NFKB2 and hsa-miR-200b targets MBNLI and MBNL 3 to downregulate their proteins expression in PC-3 cells

Formulation and optimization of ivermectin nanocrystals for enhanced topical delivery

The increasing resistance to antiparasitic drugs and limited availability of new agents highlight the need to improve the efficacy of existing treatments. Ivermectin (IVM) is commonly used for parasite treatment in humans and animals, however its efficacy is not optimal and the emergence of IVM-resistant parasites presents a challenge. In this context, the physico-chemical characteristics of IVM were modified by nanocrystallization to improve its equilibrium water-solubility and skin penetration, potentially improving its therapeutic effectiveness when applied topically. IVM-nanocrystals (IVM-NC) were prepared using microfluidization technique. The impact of several process/formulation variables on IVM-NC characteristics were studied using D-optimal statistical design. The optimized formulation was further lyophilized and evaluated using several in vitro and ex vivo tests. The optimal IVM-NC produced monodisperse particles with average diameter of 186 nm and polydispersity index of 0.4. In vitro results showed an impressive 730-fold increase in the equilibrium solubility and substantial 24-fold increase in dissolution rate. Ex vivo permeation study using pig's ear skin demonstrated 3-fold increase in dermal deposition of IVM-NC. Additionally, lyophilized IVM-NC was integrated into topical cream, and the resulting drug release profile was superior compared to that of the marketed product. Overall, IVM-NC presents a promising approach to improving the effectiveness of topically applied IVM in treating local parasitic infections

Repurposing Potential of the Antiparasitic Agent Ivermectin for the Treatment and/or Prophylaxis of COVID-19

Due to the rapid, vast, and emerging global spread of the Coronavirus Disease 2019 (COVID-19) pandemic, many drugs were quickly repurposed in a desperate attempt to unveil a miracle drug. Ivermectin (IVM), an antiparasitic macrocyclic lactone, was tested and confirmed for its in vitro antiviral activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in early 2020. Along with its potential antiviral activity, the affordability and availability of IVM resulted in a wide public interest. Across the world, trials have put IVM to test for both the treatment and prophylaxis of COVID-19, as well as its potential role in combination therapy. Additionally, the targeted delivery of IVM was studied in animals and COVID-19 patients. Through this conducted literature review, the potential value and effectiveness of the repurposed antiparasitic agent in the ongoing global emergency were summarized. The reviewed trials suggested a value of IVM as a treatment in mild COVID-19 cases, though the benefit was not extensive. On the other hand, IVM efficacy as a prophylactic agent was more evident and widely reported. In the most recent trials, novel nasal formulations of IVM were explored with the hope of an improved optimized effect

Parents' knowledge and attitude to self-medication of children with antibiotics

Objective: The aim of this study was to determine the prevalence of self-medication with antibiotics in children. Materials and Methods: This study was based on a prevalidated questionnaire distributed to 205 families in the United Arab Emirates, during the period of January-October 2014, on self-medication of their children with antibiotics. Data were collected and analyzed using Microsoft Excel® and expressed in terms of both counts and percentages. Results: The response rate was 92.7% most respondents were well educated, and with university degrees and 45 (23.7%) participants were working in the medical field or attained a medical background. The majority of children were between 1 and 12 years of age, and the family's monthly income ranged from moderate to high for most of the participants. Community pharmacy was the main source (152, 80%) of antibiotics, and the main source of information was the pharmacists, followed by doctors and medication leaflets. Reasons for self-medication with antibiotics included previous experience with symptoms (100, 52.6%), and minor illness (67, 35.3%). The majority (141, 74.2%) of participants was aware of consequences of antibiotic misuse and bacterial resistance. The most commonly utilized antibiotic for self-medication was an amoxicillin - clavulanic acid combination. Antibiotics were most commonly used without prescription for respiratory symptoms including sore throat (104, 54.7%), cold/flu (85, 44.7%), and runny nose/nasal congestion (56, 29.5%). Conclusion: Antibiotics are still used for conditions which are viral in origin and parents, misconceptions about antibiotics call for organized extensive efforts to increase public awareness of the rational antibiotic use