Bioactive glass added to autogenous bone graft in maxillary sinus augmentation: a prospective histomorphometric, immunohistochemical, and bone graft resorption assessment

Objective: The aim of this study was to compare the bone resorption rate, histomorphometry and immunohistochemical findings of bioactive glass (Biogran; Biomet, Warsaw, IN, USA) mixed with autogenous bone grafts (1:1) and autogenous bone graft isolate in maxillary sinus elevation surgery. Material and Methods: A total of 9 maxillary sinuses were grafted with Biogran with autogenous bone graft (group 1) and 12 were mixed with autogenous bone graft (group 2). Postoperative cone beam computed tomography (CBCT) was used to measure the initial graft volume after 15 days (T1), and 6 months later, another CBCT scan was performed to evaluate the final graft volume (T2) and determine the graft resorption rate. The resorption outcomes were 37.9%±18.9% in group 1 and 45.7%±18.5% in group 2 (P=0.82). After 6 months, biopsies were obtained concurrent with the placement of dental implants; these implants were subjected to histomorphometric analysis and immunohistochemical analysis for tartrate-resistant acid phosphatase (TRAP). Results: The average bone formation in group 1 was 36.6%±12.9 in the pristine bone region, 33.2%±13.3 in the intermediate region, and 45.8%±13.8 in the apical region; in group 2, the values were 34.4%±14.4, 35.0%±13.9, and 42.0%±16.6 of new bone formation in the pristine bone, intermediate, and apical regions, respectively. Immunostaining for TRAP showed poor clastic activity in both groups, which can indicate that those were in the remodeling phase. Conclusions: The similarity between the groups in the formation and maintenance of the graft volume after 6 months suggests that the bioactive glass mixed with autogenous bone (1:1) can be used safely as a bone substitute for the maxillary sinus lift

Deep Venous Thrombosis Prophylaxis In Oral And Maxillofacial Surgery: A Brazilian Survey.

Deep venous thrombosis (DVP) is a frequent disease. Prophylaxis is the best means to reduce its incidence, for lowering morbidity and mortality rates and treatment costs caused by its complications. To evaluate the knowledge and use of any kind of DVT prophylaxis by Brazilian Oral and Maxillofacial surgeons. A questionnaire was sent to all Oral and Maxillofacial surgeons associated to the Brazilian College of Oral and Maxillofacial Surgeons that have a valid e-mail address. The data retrieved was evaluated and tabulated. Of the 1100 questionnaires sent, only 4% were retrieved. The 42 retrieved were included in the study. Twenty six of the surgeons do not use any kind of deep venous thrombosis (DVT) prophylaxis, 11 use mechanical means as elastic compressive stockings or pneumatic compressive devices for prophylaxis, and 5 uses low-molecular weight heparins (LMWH) as the choice for prophylaxis. The data collected, despite the low rate of participation (4%) by the surgeons, shows that this subject still does not receive proper attention. Whereas other medical specialties make routine use of prophylactic means maybe the maxillofacial surgeons lack concern on that matter.23519-2

Bone regeneration in surgically created defects filled with autogenous bone: an epifluorescence microscopy analysis in rats

Although the search for the ideal bone substitute has been the focus of a large number of studies, autogenous bone is still the gold standard for the filling of defects caused by pathologies and traumas, and mainly, for alveolar ridge reconstruction, allowing the titanium implants installation. OBJECTIVES: The aim of this study was to evaluate the dynamics of autogenous bone graft incorporation process to surgically created defects in rat calvaria, using epifluorescence microscopy. MATERIAL AND METHODS: Five adult male rats weighing 200-300 g were used. The animals received two 5-mm-diameter bone defects bilaterally in each parietal bone with a trephine bur under general anesthesia. Two groups of defects were formed: a control group (n=5), in which the defects were filled with blood clot, and a graft group (n=5), in which the defects were filled with autogenous bone block, removed from the contralateral defect. The fluorochromes calcein and alizarin were applied at the 7th and 30th postoperative days, respectively. The animals were killed at 35 days. RESULTS: The mineralization process was more intense in the graft group (32.09%) and occurred mainly between 7 and 30 days, the period labeled by calcein (24.66%). CONCLUSIONS: The fluorochromes showed to be appropriate to label mineralization areas. The interfacial areas between fluorochrome labels are important sources of information about the bone regeneration dynamics

An encoderless high-performance synchronous reluctance motor drive

This paper presents an encoderless high-performance synchronous reluctance motor drive for traction applications. The control system is based on the active flux concept and a hybrid rotor position estimation algorithm is used, being this algorithm based on the injection of high-frequency signals at low speeds and on the position of the active flux vector for medium and high-speeds. A smooth transition algorithm between the two rotor position estimation methods is provided. Moreover, in order to improve the efficiency of the overall drive system, a loss minimization algorithm is proposed in order to reduce the motor copper losses when operating in steady-state. Experimental results obtained in the laboratory confirm the validity and adequacy of the proposed algorithms for the developed drive system.info:eu-repo/semantics/publishedVersio

The new bone formation in human maxillary sinuses using two bone substitutes with different resorption types associated or not with autogenous bone graft: a comparative histomorphometric, immunohistochemical and randomized clinical study

Objective: The aim of this study is to evaluate the new bone and connective tissue formation and the biomaterial remaining after maxillary sinus bone augmentation using 5 different bone substitutes. The osteocalcin immunolabeling was performed to demonstrate their calcification and the possibility of receiving dental implants. Methodology: 40 patients underwent maxillary sinus bone augmentation and were divided in 5 groups: Group 1 with 8 maxillary sinuses were grafted with autogenous bone graft (AB); Group 2 with 8 maxillary sinuses grafted with bioactive glass (BG); Group 3 with 8 maxillary sinuses grafted with bioactive glass added to autogenous bone graft (BG + AB) 1:1; Group 4 with 8 maxillary sinuses grafted with Bio-Oss (BO) and Group 5 with 8 maxillary sinuses grafted with Bio-Oss added to autogenous bone graft (BO + AB) 1:1. Results: In group AB, 37.8% of bone was formed in the pristine bone region, 38.1% in the intermediate and 44.5% in the apical region. In group BG, 43.6% was formed in the pristine bone, 37% in the intermediate and 49.3% in the apical region. In group BG + AB 1:1, 39.0% was formed in the pristine bone region, 34.8% in the intermediate and 36.8% in apical region. In group BO, 33.4% was formed in the pristine bone, 32.5% in the intermediate and 34.3% in the apical region. In group BO + AB 1:1, 32.8% was formed in the pristine bone, 36.1% in intermediate and 27.8% in the apical regions. The immunolabeling for osteocalcin showed an intensive staining for all groups, which could demonstrate the calcification of the bone formed. Conclusion: This study showed that the groups evaluated formed a suitable lamellar bone in the maxillary sinus reconstruction after six months of bone healing, thus being indicated to receive dental implants. &nbsp

Carcinoma Mucoepidermóide de Glândula Sublingual: Relato de Caso Clínico

The major salivary glands tumors are 3 to 5 % of all the head and neck neoplasms. The mucoepidermoid carcinoma is a malignant tumor of salivar gland most frequent in the oral cavity, preferential in females, between 3 th and 4th decades of life. One is about an aggressive injury, where the main clinical aspects include a nodular form, solid and fixed consistence increase the touch, varying among the blue shades to the red or purple. The process diagnosis is made through an association among the clinical and complemental exams, being the biopsy essential for the dignosis conclusion. The mucoepidermoid carcinoma can be classified as his differentiation degree in low, intermediate and high-grade. A recent system using five histopathological founds seems to be the ideal to accomplish that classification. Treatment usually surgical, include complete resection of the lesion, being the favorable prognostic.Os tumores das glândulas salivares maiores correspondem a aproximadamente 3 a 5% de todas as neoplasias da cabeça e pescoço. O carcinoma mucoepidermóide (CME) é o tumor maligno de glândula salivar mais frequente na cavidade bucal, ocorrendo preferencialmente no gênero feminino, entre a 3º e 4º décadas de vida. Trata-se de uma lesão agressiva, que se apresenta clinicamente por meio de um aumento de volume com aspecto nodular, de consistência sólida, fixo à palpação, variando entre as tonalidades de azul, vermelho ou púrpura. O processo diagnóstico é feito por meio de uma associação entre os exames clínico e complementar, sendo a biópsia essencial para a sua conclusão. O carcinoma mucoepidermóide pode ser classificado quanto ao seu grau de diferenciação em baixo, intermediário e alto grau. Um recente sistema utilizando cinco achados histopatológicos parece ser o ideal para realizar essa classificação. O tratamento é cirúrgico e consiste em exérese total da lesão, sendo o prognóstico favorável

Lesão queratocística em arco central mandibular. Uma região incomum

O tumor queratocístico odontogênico (TOQ), anteriormente conhecido como queratocisto odontogênico, tem características únicas, incluindo comportamento localmente agressivo, alta taxa de recorrência e aparência histológica distinta. O TOQ é uma das neoplasias odontogênicas mais comuns da mandíbula, representando cerca de 12 e 14% de todos os quistos odontogênicos das mandíbulas. Seu comportamento apresenta potencial de destruição local e extensão em tecidos, crescimento rápido, maior taxa de recorrência e uma tendência à multiplicidade. Embora várias terapias para o TOQ tenham sido documentadas na literatura, a abordagem aceita permanece indecisa. Estas variam desde métodos conservadores, como enucleação, descompressão e marsupialização, até tratamentos agressivos que incluem ostectomia periférica, crioterapia, aplicação da solução de Carnoy e ressecção da mandíbula. Todas as técnicas têm objetivos similares: a erradicação do cisto e a redução dos riscos de recidiva e morbidade cirúrgica. Este artigo tem como objetivo relatar um caso de TOQ na região anterior da mandíbula e discutir os principais métodos de tratamento cirúrgico descritos na literatura

Adesivos à base de cianoacrilato para síntese de tecido mole

FUNDAMENTOS - Adesivos teciduais têm sido muito usados para síntese de ferida, em função de ser um método indolor, rápido e de fácil execução. OBJETIVOS -Analisar e comparar compatibilidade dos adesivos, etil- cianoacrilato (Super Bonder) e butilcianoacrilato (Histoacryl), e a reparação de incisões em dorso de ratos entre o fio de sutura e os respectivos adesivos. MÉTODOS - Foram usados 15 ratos. Realizaram-se duas lojas cirúrgicas no dorso. em cada uma, foi implantado um tubo de polietileno (10mm x 1mm), os quais foram preenchidos com os adesivos Super Bonder (lado direito) e Histoacryl (lado esquerdo). As incisões, do lado esquerdo, foram coaptadas com Super Bonder, e as do lado direito, com Histoacryl. Uma incisão mediana, entre as duas incisões,foi realizada e suturada com fio de seda. Os animais foram mortos, depois de 7(sete), 35(trinta) e 120 (cento e vinte dia) dias. RESULTADOS: Os adesivos usados, no presente estudo, não promoveram reação inflamatória, quando usados para síntese das incisões. Porém, estes adesivos, quando implantados no subcutâneo, promoveram reação inflamatória até 120 (cento e vinte dia) dias, no entanto, a reação é mais intensa com Histoacryl. CONCLUSÕES: Super Bonder e Histoacryl permitem o processo cicatricial dos tecidos incisados; facilitam a sutura das incisões. Desta forma, estes podem ser utilizados para sínteses de feridas, lacerações ou incisões cutâneas.BACKGROUND: Tissue adhesives have been used for the synthesis of wound due to their painless application and quick and easy handling. OBJECTIVES: The purpose of this study was to analyze and compare the compatibility of the adhesives ethylcyanoacrylate (Super Bonder) and butyl-cyanoacrylate (Histoacryl), and to compare the reparation of incisions in the dorsum of rats with suture and the respective adhesives. METHODS: Fifteen rats were used. Two surgical pockets were created in their dorsum. A polyethylene tube (10mm x 1mm) was implanted in each one. Each tube was filled with the adhesives Super Bonder(left side) and Histoacryl (right side). The incisions on the left side were closed with Super Bonder, and the incisions on the right side, with Histoacryl. A median incision between the two other incisions was made and closed with braided silk suture. The animals were killed after, 7, 35 and 120 days. RESULTS: The adhesives used in the present study did not promote inflammatory reaction when used for the synthesis of incisions. However, when implanted subcutaneously, they caused an inflammatory reaction within 120 days. Reaction is more severe with Histoacryl. CONCLUSIONS: Super Bonder and Histoacryl can be used effectively in the healing of incised tissues; they aid in the suture of incisions. However, these adhesives can be used for the synthesis of wounds, lacerations or cutaneous incisions