Sedentary behaviour and diet across the lifespan: an updated systematic review.

Sedentary behaviour and its association with dietary intake in young people and adults are important topics and were systematically reviewed in 2011. There is a need to update this evidence given the changing nature of sedentary behaviour and continued interest in this field. This review aims to assist researchers in better interpreting the diversity of findings concerning sedentary behaviour and weight status

Optimizing Pulsar Timing Arrays to Maximize Gravitational Wave Single Source Detection: a First Cut

Pulsar Timing Arrays (PTAs) use high accuracy timing of a collection of low timing noise pulsars to search for gravitational waves in the microhertz to nanohertz frequency band. The sensitivity of such a PTA depends on (a) the direction of the gravitational wave source, (b) the timing accuracy of the pulsars in the array and (c) how the available observing time is allocated among those pulsars. Here, we present a simple way to calculate the sensitivity of the PTA as a function of direction of a single GW source, based only on the location and root-mean-square residual of the pulsars in the array. We use this calculation to suggest future strategies for the current North American Nanohertz Observatory for Gravitational Waves (NANOGrav) PTA in its goal of detecting single GW sources. We also investigate the affects of an additional pulsar on the array sensitivity, with the goal of suggesting where PTA pulsar searches might be best directed. We demonstrate that, in the case of single GW sources, if we are interested in maximizing the volume of space to which PTAs are sensitive, there exists a slight advantage to finding a new pulsar near where the array is already most sensitive. Further, the study suggests that more observing time should be dedicated to the already low noise pulsars in order to have the greatest positive effect on the PTA sensitivity. We have made a web-based sensitivity mapping tool available at http://gwastro.psu.edu/ptasm.Comment: 14 pages, 3 figures, accepted by Ap

Discovery of 28 pulsars using new techniques for sorting pulsar candidates

Modern pulsar surveys produce many millions of candidate pulsars, far more than can be individually inspected. Traditional methods for filtering these candidates, based upon the signal-to-noise ratio of the detection, cannot easily distinguish between interference signals and pulsars. We have developed a new method of scoring candidates using a series of heuristics which test for pulsar-like properties of the signal. This significantly increases the sensitivity to weak pulsars and pulsars with periods close to interference signals. By applying this and other techniques for ranking candidates from a previous processing of the Parkes Multi-beam Pulsar Survey, 28 previously unknown pulsars have been discovered. These include an eccentric binary system and a young pulsar which is spatially coincident with a known supernova remnant.Comment: To be published in Monthly Notices of the Royal Astronomical Society. 11 pages, 9 figure

Pulsar timing analysis in the presence of correlated noise

Pulsar timing observations are usually analysed with least-square-fitting procedures under the assumption that the timing residuals are uncorrelated (statistically "white"). Pulsar observers are well aware that this assumption often breaks down and causes severe errors in estimating the parameters of the timing model and their uncertainties. Ad hoc methods for minimizing these errors have been developed, but we show that they are far from optimal. Compensation for temporal correlation can be done optimally if the covariance matrix of the residuals is known using a linear transformation that whitens both the residuals and the timing model. We adopt a transformation based on the Cholesky decomposition of the covariance matrix, but the transformation is not unique. We show how to estimate the covariance matrix with sufficient accuracy to optimize the pulsar timing analysis. We also show how to apply this procedure to estimate the spectrum of any time series with a steep red power-law spectrum, including those with irregular sampling and variable error bars, which are otherwise very difficult to analyse.Comment: Accepted by MNRA

A non-contact, thermal noise based method for the calibration of lateral deflection sensitivity in atomic force microscopy

Calibration of lateral forces and displacements has been a long standing problem in lateral force microscopies. Recently, it was shown by Wagner et al. that the thermal noise spectrum of the first torsional mode may be used to calibrate the deflection sensitivity of the detector. This method is quick, non-destructive and may be performed in situ in air or liquid. Here we make a full quantitative comparison of the lateral inverse optical lever sensitivity obtained by the lateral thermal noise method and the shape independent method developed by Anderson et al. We find that the thermal method provides accurate results for a wide variety of rectangular cantilevers, provided that the geometry of the cantilever is suitable for torsional stiffness calibration by the torsional Sader method, in-plane bending of the cantilever may be eliminated or accounted for and that any scaling of the lateral deflection signal between the measurement of the lateral thermal noise and the measurement of the lateral deflection is eliminated or corrected for. We also demonstrate that the thermal method may be used to characterize the linearity of the detector signal as a function of position, and find a deviation of less than 8% for the instrument used

Observations of Six Glitches in PSR B1737-30

Six glitches have been recently observed in the rotational frequency of the young pulsar PSR B1737-30 (J1740-3015) using the 25-m Nanshan telescope of Urumqi Observatory. With a total of 20 glitches in 20 years, it is one of the most frequently glitching pulsars of the about 1750 known pulsars. Glitch amplitudes are very variable with fractional increases in rotation rate ranging from 10^{-9} to 10^{-6}. Inter-glitch intervals are also very variable, but no relationship is observed between interval and the size of the preceding glitch. There is a persistent increase in |\dot\nu|, opposite in sign to that expected from slowdown with a positive braking index, which may result from changes in the effective magnetic dipole moment of the star during the glitch.Comment: 7 pages, 10 figure

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model

© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited