IR Dust Bubbles: Probing the Detailed Structure and Young Massive Stellar Populations of Galactic HII Regions

We present an analysis of wind-blown, parsec-sized, mid-infrared bubbles and associated star-formation using GLIMPSE/IRAC, MIPSGAL/MIPS and MAGPIS/VLA surveys. Three bubbles from the Churchwell et al. (2006) catalog were selected. The relative distribution of the ionized gas (based on 20 cm emission), PAH emission (based on 8 um, 5.8 um and lack of 4.5 um emission) and hot dust (24 um emission) are compared. At the center of each bubble there is a region containing ionized gas and hot dust, surrounded by PAHs. We identify the likely source(s) of the stellar wind and ionizing flux producing each bubble based upon SED fitting to numerical hot stellar photosphere models. Candidate YSOs are also identified using SED fitting, including several sites of possible triggered star formation.Comment: 37 pages, 17 figure

Bound States of the q-Deformed AdS5 x S5 Superstring S-matrix

The investigation of the q deformation of the S-matrix for excitations on the string world sheet in AdS5 x S5 is continued. We argue that due to the lack of Lorentz invariance the situation is more subtle than in a relativistic theory in that the nature of bound states depends on their momentum. At low enough momentum |p|<E the bound states transform in the anti-symmetric representation of the super-algebra symmetry and become the solitons of the Pohlmeyer reduced theory in the relativistic limit. At a critical momentum |p|=E they become marginally unstable, and at higher momenta the stable bound states are in the symmetric representation and become the familiar magnons in the string limit as q->1. This subtlety fixes a problem involving the consistency of crossing symmetry with the relativistic limit found in earlier work. With mirror kinematics, obtained after a double Wick rotation, the bound state structure is simpler and there are no marginally unstable bound states.Comment: 25 page

The influence of psychological factors on pre-employment activities in the unemployed

Structural relationships among latent and economic deprivation, employment commitment, personal resources, and pre-employment activities are examined using a cross- sectional survey of the unemployed. The dependent variable, pre-employment activities, constitutes some of the main activities (other than their daily chores) that the unemployed engage in, including job-seeking, training, volunteer or unpaid work, and leisure activities. The research draws on concepts from Jahoda's latent deprivation theory, Fryer's agency restriction theory, and expectancy value theory. Latent and economic deprivation, employment commitment, and personal resources are expected to directly predict the type of pre-employment activities the unemployed engage in. Latent deprivation is an endogenous construct underlying measures of time structure measured by time structure, enforced activity, social contact, collective purpose, and social status. Measures of personal resources include job-search self-efficacy, self-esteem, affective disposition, and psychological wellbeing. Significant interactions between the predictor variables are also hypothesised. For example, unemployed individuals with higher perceived latent and economic deprivation and higher employment commitment are expected to engage more frequently in employment-related activities (e.g., jobseeking, training, and unpaid work participation). Supplementary hypotheses are framed to test the relative importance of each of the predictor variables. Hypotheses are tested using structural equation modelling. This study is the first stage of a longitudinal study designed to identify psychological factors that influence employment outcomes in the unemployed. Findings from the study will identify psychological barriers to active economic and social participation in the workforce that can be targeted for intervention programs for the unemployed

Space-efficient detection of unusual words

Detecting all the strings that occur in a text more frequently or less frequently than expected according to an IID or a Markov model is a basic problem in string mining, yet current algorithms are based on data structures that are either space-inefficient or incur large slowdowns, and current implementations cannot scale to genomes or metagenomes in practice. In this paper we engineer an algorithm based on the suffix tree of a string to use just a small data structure built on the Burrows-Wheeler transform, and a stack of $O(\sigma^2\log^2 n)$ bits, where $n$ is the length of the string and $\sigma$ is the size of the alphabet. The size of the stack is $o(n)$ except for very large values of $\sigma$. We further improve the algorithm by removing its time dependency on $\sigma$, by reporting only a subset of the maximal repeats and of the minimal rare words of the string, and by detecting and scoring candidate under-represented strings that $\textit{do not occur}$ in the string. Our algorithms are practical and work directly on the BWT, thus they can be immediately applied to a number of existing datasets that are available in this form, returning this string mining problem to a manageable scale.Comment: arXiv admin note: text overlap with arXiv:1502.0637

Ultra scale-down approaches to enhance the creation of bioprocesses at scale: impacts of process shear stress and early recovery stages

The sensitivity of biological materials to shear stress conditions encountered during large-scale bioprocessing makes successful scale up from the bench challenging. Ultra scale-down technologies seek to use just millilitre quantities to enhance our understanding of the impact of the process environment as a basis for process optimisation. They can help speed translation of new biological discoveries to market and reduce risks encountered in scale up. They are important both as process discovery tools and as preparative tools to yield material for study of subsequent stages. In this review the focus is on the early recovery stages post fermentation or cell culture and in particular the use of continuous-flow and dead-end centrifugation integrated with preparative stages (e.g. flocculation) and subsequent depth filtration. Examples range from therapeutic antibodies, to rationally engineered (synthetic biology) host strains, to stem cells for therapy

Helium and Hydrogen Line Ratios and The Stellar Content of Compact HII Regions

We present observations and models of the behaviour of the HI and HeI lines between 1.6 and 2.2um in a small sample of compact HII regions. As in our previous papers on planetary nebulae, we find that the `pure' 1.7007um 4^3D-3^3P and 2.16475um 7^(3,1)G-4^(3,1)F HeI recombination lines behave approximately as expected as the effective temperature of the central exciting star(s) increases. However, the 2.058um 2^1P-2^1S HeI line does not behave as the model predicts, or as seen in planetary nebulae. Both models and planetary nebulae showed a decrease in the HeI 2^1P-2^1S/HI Br gamma ratio above an effective temperature of 40000K. The compact HII regions do not show any such decrease. The problem with this line ratio is probably due to the fact that the photoionisation model does not account correctly for the high densities seen in these HII regions, and that we are therefore seeing more collisional excitation of the 2^1P level than the model predicts. It may also reflect some deeper problem in the assumed model stellar atmospheres. In any event, although the normal HeI recombination lines can be used to place constraints on the temperature of the hottest star present, the HeI 2^1P-2^1S/HI Br gamma ratio should not be used for this purpose in either Galactic HII regions or in starburst galaxies, and conclusions from previous work using this ratio should be regarded with extreme caution. We also show that the combination of the near infrared `pure' recombination line ratios with mid-infrared forbidden line data provides a good discriminant of the form of the far ultraviolet spectral energy distribution of the exciting star(s). From this we conclude that CoStar models are a poor match to the available data for our sources, though the more recent WM-basic models are a better fit.Comment: Accepted for publication in MNRA

Evaluation of options for harvest of a recombinant E. coli fermentation producing a domain antibody using ultra scale-down techniques and pilot-scale verification

Ultra scale-down (USD) methods operating at the millilitre scale were used to characterise full-scale processing of E. coli fermentation broths autolysed to different extents for release of a domain antibody. The focus was on the primary clarification stages involving continuous centrifugation followed by depth filtration. The performance of this sequence was predicted by USD studies to decrease significantly with increased extents of cell lysis. The use of polyethyleneimine (PEI) reagent was studied to treat the lysed cell broth by precipitation of soluble contaminants such as DNA and flocculation of cell debris material. The USD studies were used to predict the impact of this treatment on the performance and here it was found that the fermentation could be run to maximum productivity using an acceptable clarification process (e.g a centrifugation stage operating at 0.11 L per m(2) equivalent gravity settling area per h followed by a resultant required depth filter area of 0.07 m(2) per L supernatant). A range of USD predictions was verified at the pilot scale for centrifugation followed by depth filtration. This article is protected by copyright. All rights reserved

Manifestation of nonequilibrium initial conditions in molecular rotation: the generalized J-diffusion model

In order to adequately describe molecular rotation far from equilibrium, we have generalized the J-diffusion model by allowing the rotational relaxation rate to be angular momentum dependent. The calculated nonequilibrium rotational correlation functions (CFs) are shown to decay much slower than their equilibrium counterparts, and orientational CFs of hot molecules exhibit coherent behavior, which persists for several rotational periods. As distinct from the results of standard theories, rotational and orientational CFs are found to dependent strongly on the nonequilibrium preparation of the molecular ensemble. We predict the Arrhenius energy dependence of rotational relaxation times and violation of the Hubbard relations for orientational relaxation times. The standard and generalized J-diffusion models are shown to be almost indistinguishable under equilibrium conditions. Far from equilibrium, their predictions may differ dramatically