6,318 research outputs found
Retrieval of interatomic separations of molecules from laser-induced high-order harmonic spectra
We illustrate an iterative method for retrieving the internuclear separations
of N, O and CO molecules using the high-order harmonics generated
from these molecules by intense infrared laser pulses. We show that accurate
results can be retrieved with a small set of harmonics and with one or few
alignment angles of the molecules. For linear molecules the internuclear
separations can also be retrieved from harmonics generated using isotropically
distributed molecules. By extracting the transition dipole moment from the
high-order harmonic spectra, we further demonstrated that it is preferable to
retrieve the interatomic separation iteratively by fitting the extracted dipole
moment. Our results show that time-resolved chemical imaging of molecules using
infrared laser pulses with femtosecond temporal resolutions is possible.Comment: 14 pages, 9 figure
Ultrasoft NLL Running of the Nonrelativistic O(v) QCD Quark Potential
Using the nonrelativistic effective field theory vNRQCD, we determine the
contribution to the next-to-leading logarithmic (NLL) running of the effective
quark-antiquark potential at order v (1/mk) from diagrams with one potential
and two ultrasoft loops, v being the velocity of the quarks in the c.m. frame.
The results are numerically important and complete the description of ultrasoft
next-to-next-to-leading logarithmic (NNLL) order effects in heavy quark pair
production and annihilation close to threshold.Comment: 25 pages, 7 figures, 3 tables; minor modifications, typos corrected,
references added, footnote adde
Theoretical analysis of dynamic chemical imaging with lasers using high-order harmonic generation
We report theoretical investigations of the tomographic procedure suggested
by Itatani {\it et al.} [Nature, {\bf 432} 867 (2004)] for reconstructing
highest occupied molecular orbitals (HOMO) using high-order harmonic generation
(HHG). Using the limited range of harmonics from the plateau region, we found
that under the most favorable assumptions, it is still very difficult to obtain
accurate HOMO wavefunction, but the symmetry of the HOMO and the internuclear
separation between the atoms can be accurately extracted, especially when
lasers of longer wavelengths are used to generate the HHG. We also considered
the possible removal or relaxation of the approximations used in the
tomographic method in actual applications. We suggest that for chemical
imaging, in the future it is better to use an iterative method to locate the
positions of atoms in the molecule such that the resulting HHG best fits the
macroscopic HHG data, rather than by the tomographic method.Comment: 13 pages, 14 figure
Partially obscured human detection based on component detectors using multiple feature descriptors
This paper presents a human detection system based on component detector using multiple feature descriptors. The contribution presents two issues for dealing with the problem of partially obscured human. First, it presents the extension of feature descriptors using multiple scales based Histograms of Oriented Gradients (HOG) and parallelogram based Haar-like feature (PHF) for improving the accuracy of the system. By using multiple scales based HOG, an extensive feature space allows obtaining high-discriminated features. Otherwise, the PHF is adaptive limb shapes of human in fast computing feature. Second, learning system using boosting classifications based approach is used for training and detecting the partially obscured human. The advantage of boosting is constructing a strong classification by combining a set of weak classifiers. However, the performance of boosting depends on the kernel of weak classifier. Therefore, the hybrid algorithms based on AdaBoost and SVM using the proposed feature descriptors is one of solutions for robust human detection.This paper presents a human detection system based on component detector using multiple feature descriptors. The contribution presents two issues for dealing with the problem of partially obscured human. First, it presents the extension of feature descriptors using multiple scales based Histograms of Oriented Gradients (HOG) and parallelogram based Haar-like feature (PHF) for improving the accuracy of the system. By using multiple scales based HOG, an extensive feature space allows obtaining high-discriminated features. Otherwise, the PHF is adaptive limb shapes of human in fast computing feature. Second, learning system using boosting classifications based approach is used for training and detecting the partially obscured human. The advantage of boosting is constructing a strong classification by combining a set of weak classifiers. However, the performance of boosting depends on the kernel of weak classifier. Therefore, the hybrid algorithms based on AdaBoost and SVM using the proposed feature descriptors is one of solutions for robust human detection
Improved Perturbative QCD Approach to the Bottomonium Spectrum
Recently it has been shown that the gross structure of the bottomonium
spectrum is reproduced reasonably well within the non-relativistic boundstate
theory based on perturbative QCD. In that calculation, however, the fine
splittings and the S-P level splittings are predicted to be considerably
narrower than the corresponding experimental values. We investigate the
bottomonium spectrum within a specific framework based on perturbative QCD,
which incorporates all the corrections up to O(alpha_S^5 m_b) and O(alpha_S^4
m_b), respectively, in the computations of the fine splittings and the S-P
splittings. We find that the agreement with the experimental data for the fine
splittings improves drastically due to an enhancement of the wave functions
close to the origin as compared to the Coulomb wave functions. The agreement of
the S-P splittings with the experimental data also becomes better. We find that
natural scales of the fine splittings and the S-P splittings are larger than
those of the boundstates themselves. On the other hand, the predictions of the
level spacings between consecutive principal quantum numbers depend rather
strongly on the scale mu of the operator \propto C_A/(m_b r^2). The agreement
of the whole spectrum with the experimental data is much better than the
previous predictions when mu \simeq 3-4 GeV for alpha_S(M_Z)=0.1181. There
seems to be a phenomenological preference for some suppression mechanism for
the above operator.Comment: 26 pages, 16 figures. Minor changes, to be published in PR
Pathways to folding, nucleation events and native geometry
We perform extensive Monte Carlo simulations of a lattice model and the Go
potential to investigate the existence of folding pathways at the level of
contact cluster formation for two native structures with markedly different
geometries. Our analysis of folding pathways revealed a common underlying
folding mechanism, based on nucleation phenomena, for both protein models.
However, folding to the more complex geometry (i.e. that with more non-local
contacts) is driven by a folding nucleus whose geometric traits more closely
resemble those of the native fold. For this geometry folding is clearly a more
cooperative process.Comment: Accepted in J. Chem. Phy
Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor.
Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity. We hypothesize that cathelicidin expression correlates with obesity and modulates fat mass and hepatic steatosis.Materials and methodsMale C57BL/6 J mice were fed a high-fat diet. Streptozotocin was injected into mice to induce diabetes. Experimental groups were injected with cathelicidin and CD36 overexpressing lentiviruses. Human mesenteric fat adipocytes, mouse 3T3-L1 differentiated adipocytes and human HepG2 hepatocytes were used in the in vitro experiments. Cathelicidin levels in non-diabetic, prediabetic and type II diabetic patients were measured by enzyme-linked immunosorbent assay.ResultsLentiviral cathelicidin overexpression reduced hepatic steatosis and decreased the fat mass of high-fat diet-treated diabetic mice. Cathelicidin overexpression reduced mesenteric fat and hepatic fatty acid translocase (CD36) expression that was reversed by lentiviral CD36 overexpression. Exposure of adipocytes and hepatocytes to cathelicidin significantly inhibited CD36 expression and reduced lipid accumulation. Serum cathelicidin protein levels were significantly increased in non-diabetic and prediabetic patients with obesity, compared with non-diabetic patients with normal body mass index (BMI) values. Prediabetic patients had lower serum cathelicidin protein levels than non-diabetic subjects.ConclusionsCathelicidin inhibits the CD36 fat receptor and lipid accumulation in adipocytes and hepatocytes, leading to a reduction of fat mass and hepatic steatosis in vivo. Circulating cathelicidin levels are associated with increased BMI. Our results demonstrate that cathelicidin modulates the development of obesity
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