Regional cerebral blood flow study in postictal psychosis complication complex partial seizure

published_or_final_versio

Treatment of dural sinus thrombosis with low-molecular-weight heparin

published_or_final_versio

Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese

published_or_final_versio

Causes of dural sinus thrombosis in a Chinese community

published_or_final_versio

Planar Antenna Design for Internet of Things Applications

Planar antenna plays an important role in Internet of Things (IoT) applications because of its small size, low profile and low cost. In IoT wireless module, antenna is typically occupied one-third size of overall circuit; therefore, planar antenna, i.e., integrated on printed circuit board (PCB) is one of attractive design. In this chapter, the fundamental of antenna is firstly discussed. Printed Inverted-F Antenna (PIFA) is taken as an example to explain the design process of simple planar antenna and a size-reduced 2.4 GHz ISM band PIFA is used for experimental explanation for the short-range IoT applications. Finally, a wideband antenna is shown as wideband planar antenna for short-range and long-range IoT applications

Magnetic rogue wave in a perpendicular anisotropic ferromagnetic nanowire with spin-transfer torque

We present the current controlled motion of dynamic soliton embedded in spin wave background in ferromagnetic nanowire. With the stronger breather character we get the novel magnetic rogue wave and clarify its formation mechanism. The generation of magnetic rogue wave is mainly arose from the accumulation of energy and magnons toward to its central part. We also observe that the spin-polarized current can control the exchange rate of magnons between envelope soliton and background, and the critical current condition is obtained analytically. Even more interesting is that the spin-transfer torque plays the completely opposite role for the cases of below and above the critical value.Comment: 5 figure

Identification of a novel bat papillomavirus by metagenomics

published_or_final_versio

Intrathecal Morphine and Post-Operative Pain Relief in Robotic Surgeries : A Systematic Review and Meta-Analysis

Peer reviewedPublisher PD

A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2.

Breast cancer is the most common type of female cancer. Reactive oxygen species (ROS) are vital in regulating signaling pathways that control cell survival and cell proliferation. Chemotherapeutic drugs such as anthracyclines induce cell death via ROS induction. Chemoresistance development is associated with adaptive response to oxidative stress. NRF2 is the main regulator of cytoprotective response to oxidative stress. NRF2 can enhance cell growth, antioxidant expression, and chemoresistance by providing growth advantage for malignant cells. Previously, we identified BQ323636.1 (BQ), a novel splice variant of nuclear co-repressor NCOR2, which can robustly predict tamoxifen resistance in primary breast cancer. In this study, we found that BQ was overexpressed in epirubicin-resistant cells and demonstrated that BQ overexpression could reduce the levels of epirubicin-induced ROS and confer epirubicin resistance. In vivo analysis using tissue microarray of primary breast cancer showed direct correlation between BQ expression and chemoresistance. In vitro experiments showed BQ could modulate NRF2 transcriptional activity and upregulate antioxidants. Luciferase reporter assays showed that although NCOR2 repressed the transcriptional activity of NRF2, the presence of BQ reduced this repressive activity. Co-immunoprecipitation confirmed that NCOR2 could bind to NRF2 and that this interaction was compromised by BQ overexpression, leading to increased transcriptional activity in NRF2. Our findings suggest BQ can regulate the NRF2 signaling pathway via interference with NCOR2 suppressive activity and reveals a novel role for BQ as a modulator of chemoresistance in breast cancer