Planering av ett integrerat verksamhetssystem för ett småföretag inom servicesektorn

I dagens läge börjar kunderna intressera sig allt mera för företagens säkerhets- och miljöpolitik. Detta resulterar i att större företag i allt större utsträckning börjar kräva att deras underleverantörer har certifiering och ledningssystem i skick. Detta examensarbete har utförts till en följd av detta. Examensarbetet har utförts som en del av Ab Engman Services Oy’s process i att bli ett mera systematiserat företag. En annan del av syftet har varit att man vill stärka företagets brand. Arbetet har tagit form med hjälp av intervjuer, litteraturstudier och analys av tidigare utförda arbeten och studier. Med detta examensarbete kunde konstateras att man erlagt goda grunder och förståelser inför implementeringsfasen av det integrerade verksamhetssystemet, vilket är nästa fas i projektet mot certifiering enligt standarderna ISO 9001 & 14001 och OHSAS 18001 sommaren 2016 hos Engman Services.Nowadays, customers are showing more and more interest in different corporations’ safety and environmental policies. As a result, larger corporations are widely beginning to require that their subcontractors have certification and management systems in order. This bachelor’s thesis has been executed as a result hereof. This bachelor’s thesis has been executed as a part of Ab Engman Services Oy’s process to become a more systematic corporation. Another purpose of this work has been to improve the company’s brand. The work has been shaped via interviews, literature studies and analyses of earlier performed works and studies. A good basis and comprehension prior to the implementation phase of the integrated management system were created by this thesis. Implementation is the next phase of the project and certification according to ISO 9001 & 14001 and OHSAS 18001 will be carried out during the summer of 2016 at Engman Services.Nykyään asiakkaat ovat yhä kiinnostuneempia eri yrityksien turvallisuus- ja ympäristöpolitiikasta. Tämä aiheuttaa sen, että suuremmat yritykset yhä suuremmassa määrin alkavat vaatia, että heidän alihankkijoilla on sertifioinnit ja johtajajärjestelmät kunnossa. Tämä opinnäytetyö vastaa näihin tarpeisiin. Opinnäytetyö on suoritettu osana Ab Engman Services Oy:n prosessia tulla systematisoituneemmaksi yritykseksi. Toinen syy tähän opinnäytetyöhön on se, että halutaan vahvistaa yrityksen brändiä. Työ pohjautuu haastatteluihin, kirjallisuustutkintoihin ja aiemmin suoritettujen töiden ja tutkimuksien analyyseihin. Tämän opinnäytetyön perusteella voitiin huomata, että on luotu hyviä perusteita ja tulkintoja integroidun toimintajärjestelmän implementointivaiheeseen, joka on seuraava vaihe projektissa: sertifiointi ISO 9001- ja 14001- sekä OHSAS 18001-standardien mukaan, kesällä 2016 Engman Servicellä

Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death

NEDD8 is a ubiquitin‐like protein that activates cullin‐RING E3 ubiquitin ligases (CRLs). Here, we identify a novel role for NEDD8 in regulating the activity of poly(ADP‐ribose) polymerase 1 (PARP‐1) in response to oxidative stress. We show that treatment of cells with H2O2 results in the accumulation of NEDD8 chains, likely by directly inhibiting the deneddylase NEDP1. One chain type, an unanchored NEDD8 trimer, specifically bound to the second zinc finger domain of PARP‐1 and attenuated its activation. In cells in which Nedp1 is deleted, large amounts of tri‐NEDD8 constitutively form, resulting in inhibition of PARP‐1 and protection from PARP‐1‐dependent cell death. Surprisingly, these NEDD8 trimers are additionally acetylated, as shown by mass spectrometry analysis, and their binding to PARP‐1 is reduced by the overexpression of histone de‐acetylases, which rescues PARP‐1 activation. Our data suggest that trimeric, acetylated NEDD8 attenuates PARP‐1 activation after oxidative stress, likely to delay the initiation of PARP‐1‐dependent cell death

Breaking barriers, Building bridges: Collaborative forest landscape restoration handbook

Breaking Barriers, Building Bridges: Collaborative Forest Landscape Restoration Handbook explores the various barriers to landscape-scale, collaborative forest restoration and the innovative ways to bridge those barriers. The handbook, which is published by the ERI, features a foreword by Dr. W. Wallace Covington, chapters about collaboration, ecological economics, planning and NEPA development, multi-party monitoring, implementation, and adaptive management all within the context of landscape-scale forest restoration projects across the American West. It also chronicles pioneering ventures in large-scale, collaborative forest restoration and the emerging process that stakeholders, agencies, environmental groups, Native American tribes, and others have begun under the auspices of the Collaborative Forest Landscape Restoration Program and other collaborative efforts. While the process is an evolving one, people with diverse interests continue to work collectively under a shared goal: to restore health and resiliency to the nation's forested landscapes, while protecting people, communities, and enhancing local and regional economies

Investigating practice variation in a changing primary care. A multilevel perspective on The Skaraborg Primary Care Database

Background and Aims: Differences in the clinical care of patients have been explained through the concept of practice variation, that is, the occurrence of established local medical procedures that varies between geographic areas. The primary measures introduced to eliminate undesirable differences in medical care are the introduction of medical guidelines and economical incentives that rewards the desired behaviour. Practice variation in primary care can be seen on different hierarchically organised levels (e.g. patient, physician, health care center (HCC)) and Multilevel Regression analysis techniques (MLRA) offer a suitable tool to analyse these kinds of data. Data extracted from computerised medical records are ideal for studying practice variation as they often comprise information from several levels. In the region of Skaraborg in Sweden a new database, the Skaraborg Primary care database (SPCD), comprising information extracted form the computerised medical records of all public health care centres has recently been established. The overall aims of this thesis were to examine the usefulness and quality of the SPCD database for research and to study practice variation in some important areas such as diagnosis registration, laboratory analysis ordering and prescriptions. Furthermore, the influence of changes in the economic incentives on physician’s clinical behaviour was investigated. Material and Methods: In all studies data from the SPCD comprising data on individual patients from all public health care centres was used. The registration of diagnoses in the SPCD was validated by comparing the occurrence of recorded diagnosis in the diagnosis register of the database with the free text part of the patient medical records for a randomly selected sample of patients. Multilevel logistic regression analysis was used to investigate practice variation in prescribing and laboratory test ordering, focusing on measures of both frequency and variance. The effects of changes in economic incentives for diagnosis coding and prescribing were examined by comparing multilevel analysis results before and after implementation of the economic incentives. Results and Conclusions: The frequency of registration of ICD codes varied between diagnoses but also between physicians and HCCs. Different diagnoses need to be validated separately. The occurrence of practice variation was demonstrated both in laboratory test ordering where the physician level was the most important level and in prescribing where physician and HCC levels were equally important in explaining the observed variation. A positive effect in adherence to prescribing guidelines was demonstrated after the introduction of a decentralised drug budget. The introduction of a strong economic incentive for ICD coding showed the expected rise in coding rates and decline in variation, directly affecting the diagnoses register of the research database. Changes in the healthcare process will have a direct impact on the research database. Knowledge about the local health care processes is essential when interpreting database data. The SPCD seems as a good complement to previously established databases and quality registers, offering new possibilities when studying primary care

Fee Arrangements and Fee Shifting: Lessons From the Experience in Ontario

About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid receptor alpha as a marker of tamoxifen resistance. Using quantitative mass spectrometry-based proteomics, we show that retinoic acid receptor alpha protein networks and levels differ in a tamoxifen-sensitive (MCF7) and a tamoxifen-resistant (LCC2) cell line. High intratumoural retinoic acid receptor alpha protein levels also correlate with reduced relapse-free survival in oestrogen receptor alpha-positive breast cancer patients treated with adjuvant tamoxifen solely. A similar retinoic acid receptor alpha expression pattern is seen in a comparable independent patient cohort. An oestrogen receptor alpha and retinoic acid receptor alpha ligand screening reveals that tamoxifen-resistant LCC2 cells have increased sensitivity to retinoic acid receptor alpha ligands and are less sensitive to oestrogen receptor alpha ligands compared with MCF7 cells. Our data indicate that retinoic acid receptor alpha may be a novel therapeutic target and a predictive factor for oestrogen receptor alpha-positive breast cancer patients treated with adjuvant tamoxifen

Olkiluoto biosphere description 2012

Posiva-raportti, tehtävänumero 721511