Persistent and Reversible Phase Control in GdMnO3_3 near the Phase Boundary

We have investigated temperature and magnetic-field dependence of dielectric properties in the orthorhombic GdMnO$_3$ single crystal which is located near the phase boundary between the ferroelectric/spiral-antiferromagnetic phase and the paraelectric/$A$-type-antiferromagnetic one. In this compound, strong phase competition between these two phases results in a unique phase diagram with large temperature and magnetic-field hystereses. Based on the phase diagram, we have successfully demonstrated the persistent and reversible phase switching between them by application of magnetic fields.Comment: 4 pages, 2 figures, proceeding of 25th International Conference on Low Temperature Physics LT2

Longitudinal observation of insulin secretory ability before and after the onset of immune checkpoint inhibitor-induced diabetes mellitus: A report of two cases

Immune checkpoint inhibitor-induced diabetes mellitus is a rare immune-related adverse event. This report illustrates clinical data and insulin secretory ability before and after the onset of immune checkpoint inhibitor-induced diabetes

Anomalous Coexistence of Ferroelectric Phases (P∥aP\parallel a and P∥cP\parallel c) in Orthorhombic Eu1−y_{1-y}Yy_yMnO3_3 (y>0.5y>0.5) Crystals

We have investigated the magnetic and dielectric properties of orthorhombic Eu$_{1-y}$Y$_y$MnO$_3$ ($0\leq y\leq 0.6$) single crystals without the presence of the 4$f$ magnetic moments of the rare-earth ions. In $y\geq 0.2$, the magnetic-structure driven ferroelectricity is observed. The ferroelectric transition temperature is steeply reducing with increasing $y$. In $y\geq 0.52$, two ferroelectric phases ($P\parallel a$ and $P\parallel c$) are coexistent at low temperatures. In these phases, ferroelectricity has different origin, which is evidenced by the distinctive poling-electric-field dependence of electric polarization. Namely, the electric polarization along the c axis ($P_c$) is easily saturated by a poling electric field, therefore $P_c$ is caused by the $bc$ spiral antiferromagnetic order. On the other hand, the electric polarization along the a axis ($P_a$) is probably attributed to the collinear $E$-type antiferromagnetic order, because $P_a$ is unsaturated even in a poling field of $10^6$ V/m.Comment: 10 pages, 4figures, to be published in Journal of the Physical Society of Japa

衣服デザインに及ぼす錯視効果に関する研究 : ツェルナー錯視の活用

In this study, it is examined whether the Zollner illusion effect is useful for apparel design, or not. Zollner illusion effect seems parallel lines to slant. Applying this effect to the apparel design, we may have the impression that it looks the straight body line to incline. As a result, we get the conclusion that the Zollner illusion effect is slightly useful for giving impression of slender waist

A distinct effect of transient and sustained upregulation of cellular factor XIII in the goldfish retina and optic nerve on optic nerve regeneration

Unlike in mammals, fish retinal ganglion cells (RGCs) have a capacity to repair their axons even after optic nerve transection. In our previous study, we isolated a tissue type transglutaminase (TG) from axotomized goldfish retina. The levels of retinal TG (TG R) mRNA increased in RGCs 1-6 weeks after nerve injury to promote optic nerve regeneration both in vitro and in vivo. In the present study, we screened other types of TG using specific FITC-labeled substrate peptides to elucidate the implications for optic nerve regeneration. This screening showed that the activity of only cellular coagulation factor XIII (cFXIII) was increased in goldfish optic nerves just after nerve injury. We therefore cloned a full-length cDNA clone of FXIII A subunit (FXIII-A) and studied temporal changes of FXIII-A expression in goldfish optic nerve and retina during regeneration. FXIII-A mRNA was initially detected at the crush site of the optic nerve 1 h after injury; it was further observed in the optic nerve and achieved sustained long-term expression (1-40 days after nerve injury). The cells producing FXIII-A were astrocytes/microglial cells in the optic nerve. By contrast, the expression of FXIII-A mRNA and protein was upregulated in RGCs for a shorter time (3-10 days after nerve injury). Overexpression of FXIII-A in RGCs achieved by lipofection induced significant neurite outgrowth from unprimed retina, but not from primed retina with pretreatment of nerve injury. Addition of extracts of optic nerves with injury induced significant neurite outgrowth from primed retina, but not from unprimed retina without pretreatment of nerve injury. The transient increase of cFXIII in RGCs promotes neurite sprouting from injured RGCs, whereas the sustained increase of cFXIII in optic nerves facilitates neurite elongation from regrowing axons. © 2012 Elsevier Ltd. All rights reserved

An Initial Step of GAS-Containing Autophagosome-Like Vacuoles Formation Requires Rab7

Group A streptococcus (GAS; Streptococcus pyogenes) is a common pathogen that invades non-phagocytic human cells via endocytosis. Once taken up by cells, it escapes from the endocytic pathway to the cytoplasm, but here it is contained within a membrane-bound structure termed GAS-containing autophagosome-like vacuoles (GcAVs). The autophagosome marker GFP-LC3 associates with GcAVs, and other components of the autophagosomal pathway are involved in GcAV formation. However, the mechanistic relationship between GcAV and canonical autophagy is largely unknown. Here, we morphologically analyzed GcAV formation in detail. Initially, a small, GFP-LC3-positive GcAV sequesters each streptococcal chain, and these then coalesce into a single, large GcAV. Expression of a dominant-negative form of Rab7 or RNAi-mediated knockdown of Rab7 prevented the initial formation of small GcAV structures. Our results demonstrate that mechanisms of GcAV formation includes not only the common machinery of autophagy, but also Rab7 as an additional component, which is dispensable in canonical autophagosome formation

A市市民の健康習慣とはつらつ感の実態 2016年の調査から(第3報)

　A市市民の健康習慣とはつらつ感の実態を明らかにするため，年齢階級別かつ性別で市民3000 人を無作為に抽出し，郵送による自記式質問紙調査を行った．その結果，1248 件（回収率41.6%）を回収し，性別，年齢，はつらつ感の記載のないものを除外し，1207 件を分析対象とした（有効回答率96.7%）．はつらつ感は「毎日はつらつ」155 人（12.8%），「まあまあはつらつ」727 人（60.2%），「あまりはつらつとしていない」261人（21.6%），「はつらつとしていない」64 人（5.3%）であった．はつらつ群と非はつらつ群の2 群間で有意差がみられたのは，「心や精神の病気」，「主観的健康観」と，健康習慣では，「30 分以上の早歩き」「エスカレーター・エレベーターの使用」「運動不足の自覚」「運動する仲間」「主食・主菜・副菜のそろった食事」「家族や仲間との楽しい食事」「よく噛むことの心がけ」「食生活の問題意識」「地元の食材の利用」「定期的な体重測定」「自分のBMI の認識」「年1 回の健康診査の受診」「身近に相談できる人・環境」「睡眠による休養」「近所の人のお互いに助け合う気持ち」「近所の人との会話」等の30 項目であった．　A市市民がはつらつと生活するためには，適切な運動や栄養バランスの良い食事等を啓蒙するとともに，健康管理では体重管理や健康診査の受診の勧奨が重要であり，また，はつらつ感は心の状態が反映されていることが推察され，近所の人との会話やつながり等ソーシャル・キャピタルの醸成や心の健康支援の取り組みの充実が示唆された

The Quiescent Intracluster Medium in the Core of the Perseus Cluster

Clusters of galaxies are the most massive gravitationally-bound objects in the Universe and are still forming. They are thus important probes of cosmological parameters and a host of astrophysical processes. Knowledge of the dynamics of the pervasive hot gas, which dominates in mass over stars in a cluster, is a crucial missing ingredient. It can enable new insights into mechanical energy injection by the central supermassive black hole and the use of hydrostatic equilibrium for the determination of cluster masses. X-rays from the core of the Perseus cluster are emitted by the 50 million K diffuse hot plasma filling its gravitational potential well. The Active Galactic Nucleus of the central galaxy NGC1275 is pumping jetted energy into the surrounding intracluster medium, creating buoyant bubbles filled with relativistic plasma. These likely induce motions in the intracluster medium and heat the inner gas preventing runaway radiative cooling; a process known as Active Galactic Nucleus Feedback. Here we report on Hitomi X-ray observations of the Perseus cluster core, which reveal a remarkably quiescent atmosphere where the gas has a line-of-sight velocity dispersion of 164+/-10 km/s in a region 30-60 kpc from the central nucleus. A gradient in the line-of-sight velocity of 150+/-70 km/s is found across the 60 kpc image of the cluster core. Turbulent pressure support in the gas is 4% or less of the thermodynamic pressure, with large scale shear at most doubling that estimate. We infer that total cluster masses determined from hydrostatic equilibrium in the central regions need little correction for turbulent pressure.Comment: 31 pages, 11 Figs, published in Nature July