Über die Nutzung der fehlerhaften DNA-Reparatur BRCA1 defizienter Pankreaskarzinomzellen in der medikamentösen Therapie

In this study we show that BRCA1-deficient murine pancreatic carcinoma cells are sensitive to DNA damaging drugs like Mitomycin C and Cisplatin

Phase Transitions from Saddles of the Potential Energy Landscape

The relation between saddle points of the potential of a classical many-particle system and the analyticity properties of its thermodynamic functions is studied. For finite systems, each saddle point is found to cause a nonanalyticity in the Boltzmann entropy, and the functional form of this nonanalytic term is derived. For large systems, the order of the nonanalytic term increases unboundedly, leading to an increasing differentiability of the entropy. Analyzing the contribution of the saddle points to the density of states in the thermodynamic limit, our results provide an explanation of how, and under which circumstances, saddle points of the potential energy landscape may (or may not) be at the origin of a phase transition in the thermodynamic limit. As an application, the puzzling observations by Risau-Gusman et al. on topological signatures of the spherical model are elucidated.Comment: 5 pages, no figure

Thermally Assisted Spin Hall Effect

The spin polarized charge transport is systematically analyzed as a thermally driven stochastic process. The approach is based on Kramers' equation describing the semiclassical motion under the inclusion of stochastic and damping forces. Due to the relativistic spin-orbit coupling the damping experiences a relativistic correction leading to an additional contribution within the spin Hall conductivity. A further contribution to the conductivity is originated from the averaged underlying crystal potential, the mean value of which depends significantly on the electric field. We derive an exact expression for the electrical conductivity. All corrections are estimated in lowest order of a relativistic approach and in the linear response regime.Comment: 12 pages, 1 figur

causalgraph: A Python Package for Modeling, Persisting and Visualizing Causal Graphs Embedded in Knowledge Graphs

This paper describes a novel Python package, named causalgraph, for modeling and saving causal graphs embedded in knowledge graphs. The package has been designed to provide an interface between causal disciplines such as causal discovery and causal inference. With this package, users can create and save causal graphs and export the generated graphs for use in other graph-based packages. The main advantage of the proposed package is its ability to facilitate the linking of additional information and metadata to causal structures. In addition, the package offers a variety of functions for graph modeling and plotting, such as editing, adding, and deleting nodes and edges. It is also compatible with widely used graph data science libraries such as NetworkX and Tigramite and incorporates a specially developed causalgraph ontology in the background. This paper provides an overview of the package's main features, functionality, and usage examples, enabling the reader to use the package effectively in practice

Drug Hypersensitivity Syndrome toCarbamazepine and Human Herpes Virus 6 Infection: Case Reportand Literature Review

Abstract.: We describe a patient with a drug-induced hypersensitivity syndrome to carbamazepine and a concomitant active infection with human herpes virus 6 (HHV-6). The potential role of HHV-6 regarding the drug-induced hypersensitivity syndrome is discussed and the main clinical features of this potentially fatal adverse drug reaction are highlighte

An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay

Herein, we report a novel whole-cell screening assay using Lactobacillus casei as a model microorganism to identify inhibitors of energy-coupling factor (ECF) transporters. This promising and underexplored target may have important pharmacological potential through modulation of vitamin homeostasis in bacteria and, importantly, it is absent in humans. The assay represents an alternative, cost-effective and fast solution to demonstrate the direct involvement of these membrane transporters in a native biological environment rather than using a low-throughput in vitro assay employing reconstituted proteins in a membrane bilayer system. Based on this new whole-cell screening approach, we demonstrated the optimization of a weak hit compound (2) into a small molecule (3) with improved in vitro and whole-cell activities. This study opens the possibility to quickly identify novel inhibitors of ECF transporters and optimize them based on structure–activity relationships

Long-Period Giant Companions to Three Compact, Multiplanet Systems

Understanding the relationship between long-period giant planets and multiple smaller short-period planets is critical for formulating a complete picture of planet formation. This work characterizes three such systems. We present Kepler-65, a system with an eccentric (e = 0.28 ± 0.07) giant planet companion discovered via radial velocities (RVs) exterior to a compact, multiply transiting system of sub-Neptune planets. We also use precision RVs to improve mass and radius constraints on two other systems with similar architectures, Kepler-25 and Kepler-68. In Kepler-68 we propose a second exterior giant planet candidate. Finally, we consider the implications of these systems for planet formation models, particularly that the moderate eccentricity in Kepler-65\u27s exterior giant planet did not disrupt its inner system

An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay

Herein, we report a novel whole-cell screening assay using Lactobacillus casei as a model microorganism to identify inhibitors of energy-coupling factor (ECF) transporters. This promising and underexplored target may have important pharmacological potential through modulation of vitamin homeostasis in bacteria and, importantly, it is absent in humans. The assay represents an alternative, cost-effective and fast solution to demonstrate the direct involvement of these membrane transporters in a native biological environment rather than using a low-throughput in vitro assay employing reconstituted proteins in a membrane bilayer system. Based on this new whole-cell screening approach, we demonstrated the optimization of a weak hit compound (2) into a small molecule (3) with improved in vitro and whole-cell activities. This study opens the possibility to quickly identify novel inhibitors of ECF transporters and optimize them based on structure–activity relationships