Wildlife-friendly farming increases crop yield: evidence for ecological intensification

Ecological intensification has been promoted as a means to achieve environmentally sustainable increases in crop yields by enhancing ecosystem functions that regulate and support production. There is, however, little direct evidence of yield benefits from ecological intensification on commercial farms growing globally important foodstuffs (grains, oilseeds and pulses). We replicated two treatments removing 3 or 8% of land at the field edge from production to create wildlife habitat in 50–60 ha patches over a 900 ha commercial arable farm in central England, and compared these to a business as usual control (no land removed). In the control fields, crop yields were reduced by as much as 38% at the field edge. Habitat creation in these lower yielding areas led to increased yield in the cropped areas of the fields, and this positive effect became more pronounced over 6 years. As a consequence, yields at the field scale were maintained—and, indeed, enhanced for some crops—despite the loss of cropland for habitat creation. These results suggested that over a 5-year crop rotation, there would be no adverse impact on overall yield in terms of monetary value or nutritional energy. This study provides a clear demonstration that wildlife-friendly management which supports ecosystem services is compatible with, and can even increase, crop yields

Wildlife-friendly farming benefits rare birds, bees and plants

Agricultural intensification is a leading cause of global biodiversity loss, especially for threatened and near-threatened species. One widely implemented response is ‘wildlife-friendly farming’, involving the close integration of conservation and extensive farming practices within agricultural landscapes. However, the putative benefits from this controversial policy are currently either unknown or thought unlikely to extend to rare and declining species. Here, we show that new, evidence-based approaches to habitat creation on intensively managed farmland in England can achieve large increases in plant, bee and bird species. In particular, we found that habitat enhancement methods designed to provide the requirements of sensitive target biota consistently increased the richness and abundance of both rare and common species, with 10-fold to greater than 100-fold more rare species per sample area than generalized conventional conservation measures. Furthermore, targeting landscapes of high species richness amplified beneficial effects on the least mobile taxa: plants and bees. Our results provide the first unequivocal support for a national wildlife-friendly farming policy and suggest that this approach should be implemented much more extensively to address global biodiversity loss. However, to be effective, these conservation measures must be evidence-based, and developed using sound knowledge of the ecological requirements of key species

Living on the edge: utilising lidar data to assess the importance of vegetation structure for avian diversity in fragmented woodlands and their edges

Context: In agricultural landscapes, small woodland patches can be important wildlife refuges. Their value in maintaining biodiversity may, however, be compromised by isolation, and so knowledge about the role of habitat structure is vital to understand the drivers of diversity. This study examined how avian diversity and abundance were related to habitat structure in four small woods in an agricultural landscape in eastern England. Objectives: The aims were to examine the edge effect on bird diversity and abundance, and the contributory role of vegetation structure. Specifically: what is the role of vegetation structure on edge effects, and which edge structures support the greatest bird diversity? Methods: Annual breeding bird census data for 28 species were combined with airborne lidar data in linear mixed models fitted separately at (i) the whole wood level, and (ii) for the woodland edges only. Results: Despite relatively small woodland areas (4.9–9.4 ha), bird diversity increased significantly towards the edges, being driven in part by vegetation structure. At the whole woods level, diversity was positively associated with increased vegetation above 0.5 m and especially with increasing vegetation density in the understorey layer, which was more abundant at the woodland edges. Diversity along the edges was largely driven by the density of vegetation below 4 m. Conclusions: The results demonstrate that bird diversity was maximised by a diverse vegetation structure across the wood and especially a dense understorey along the edge. These findings can assist bird conservation by guiding habitat management of remaining woodland patches

Including PrEP for key populations in combination HIV prevention: a mathematical modelling analysis of Nairobi as a case-study

Background: The role of PrEP in combination HIV prevention remains uncertain. We aimed to identify an optimal portfolio of interventions to reduce HIV incidence for a given budget, and to identify the circumstances in which PrEP could be used in Nairobi, Kenya. Methods: A mathematical model was developed to represent HIV transmission among specific key populations (female sex workers (FSW), male sex workers (MSW), and men who have sex with men (MSM)) and among the wider population of Nairobi. The scale-up of existing interventions (condom promotion, anti-retroviral therapy (ART) and male circumcision) for key populations and the wider population as have occurred in Nairobi is represented. The model includes a detailed representation of a Pre-Exposure Prophylaxis (PrEP) intervention and is calibrated to prevalence and incidence estimates specific to key populations and the wider population. Findings: In the context of a declining epidemic overall but with a large sub-epidemic among MSM and MSW, an optimal prevention portfolio for Nairobi should focus on condom promotion for MSW and MSM in particular, followed by improved ART retention, earlier ART, and male circumcision as the budget allows. PrEP for MSW could enter an optimal portfolio at similar levels of spending to when earlier ART is included, however PrEP for MSM and FSW would be included only at much higher budgets. If PrEP for MSW cost as much $500, average annual spending on the interventions modelled would need to be less than$3·27 million for PrEP for MSW to be excluded from an optimal portfolio. Estimated costs per infection averted when providing PrEP to all FSW regardless of their risk of infection, and to high risk FSW only, are $65,160 (95$43,520 - $90,250) and$10,920 (95% credible interval: $4,700 -$51,560) respectively. Interpretation: PrEP could be a useful contribution to combination prevention, especially for underserved key populations in Nairobi. An ongoing demonstration project will provide important information regarding practical aspects of implementing PrEP for key populations in this setting

Long-term woodland restoration on lowland farmland through passive rewilding.

Natural succession of vegetation on abandoned farmland provides opportunities for passive rewilding to re-establish native woodlands, but in Western Europe the patterns and outcomes of vegetation colonisation are poorly known. We combine time series of field surveys and remote sensing (lidar and photogrammetry) to study woodland development on two farmland fields in England over 24 and 59 years respectively: the New Wilderness (2.1 ha) abandoned in 1996, and the Old Wilderness (3.9 ha) abandoned in 1961, both adjacent to ancient woodland. Woody vegetation colonisation of the New Wilderness was rapid, with 86% vegetation cover averaging 2.9 m tall after 23 years post-abandonment. The Old Wilderness had 100% woody cover averaging 13.1 m tall after 53 years, with an overstorey tree-canopy (≥ 8 m tall) covering 91%. By this stage, the structural characteristics of the Old Wilderness were approaching those of neighbouring ancient woodlands. The woody species composition of both Wildernesses differed from ancient woodland, being dominated by animal-dispersed pedunculate oak Quercus robur and berry-bearing shrubs. Tree colonisation was spatially clustered, with wind-dispersed common ash Fraxinus excelsior mostly occurring near seed sources in adjacent woodland and hedgerows, and clusters of oaks probably resulting from acorn hoarding by birds and rodents. After 24 years the density of live trees in the New Wilderness was 132/ha (57% oak), with 390/ha (52% oak) in the Old Wilderness after 59 years; deadwood accounted for 8% of tree stems in the former and 14% in the latter. Passive rewilding of these 'Wilderness' sites shows that closed-canopy woodland readily re-established on abandoned farmland close to existing woodland, it was resilient to the presence of herbivores and variable weather, and approached the height structure of older woods within approximately 50 years. This study provides valuable long-term reference data in temperate Europe, helping to inform predictions of the potential outcomes of widespread abandonment of agricultural land in this region

The MUK eight protocol: a randomised phase II trial of cyclophosphamide and dexamethasone in combination with ixazomib, in relapsed or refractory multiple myeloma (RRMM) patients who have relapsed after treatment with thalidomide, lenalidomide and a proteasome inhibitor

Background Multiple myeloma is a plasma cell tumour with approximately 5500 new cases in the UK each year. Ixazomib is a next generation inhibitor of the 20S proteasome and is thought to be an effective treatment for those who have relapsed from bortezomib. The combination of cyclophosphamide and dexamethasone (CD) is a recognised treatment option for patients with relapsed refractory multiple myeloma (RRMM) who have relapsed after treatment with bortezomib and lenalidomide, whilst also often being combined with newer proteasome inhibitors. The most apparent combination for ixazomib is therefore with CD. Methods MUK eight is a randomised, controlled, open, parallel group, multi-centre phase II trial that will recruit patients with RRMM who have relapsed after treatment with thalidomide, lenalidomide, and a proteasome inhibitor. The primary objective of the trial is to evaluate whether ixazomib in combination with cyclophosphamide and dexamethasone (ICD) has improved clinical activity compared to CD in terms of progression-free survival (PFS). Secondary objectives include comparing toxicity profiles and the activity and cost-effectiveness of both treatments. Since opening, the trial has been amended to allow all participants who experience disease progression (as per the IMWG criteria) on the CD arm to subsequently switch to receive ICD treatment, once progression has been confirmed with two clinical members of the Trial Management Group (TMG). This ‘switch’ phase of the study is exploratory and will assess second progression-free survival measured from randomisation to second disease progression (PFS2) and progression-free survival from the point of switching to second disease progression (PFS Switch) in participants who switch from CD to ICD treatment. Discussion Development of ixazomib offers the opportunity to further investigate the value of proteasome inhibition through oral administration in the treatment of RRMM. Previous studies investigating the safety and efficacy of ICD in patients with RRMM demonstrate a toxicity profile consistent with ixazomib in combination with lenalidomide and dexamethasone, whilst the combination showed possible activity in RRMM patients. Further investigation of the anti-tumour effect of this drug in RRMM patients is therefore warranted, especially since no trials comparing CD with ICD have been completed at present. Trial registration ISRCTN number: ISRCTN58227268. Registered on 26 August 2015

Morphology, geographical variation and the subspecies of marsh tit Poecile palustris in Britain and central Europe

Capsule: All British Marsh Tits belong to subspecies Poecile palustris dresseri, being smaller than nominate P. p. palustris of central Europe. Aims: Determining the subspecies of Marsh Tit in Britain to test whether ssp. P. p. palustris occurs in northern England and Scotland, by assessing regional variation in size compared with central European birds. Methods: 1147 wing length and 250 tail length measurements from 953 Marsh Tits were compared between eight British locations to test for regional variation. Biometrics were compared between birds from Britain and six locations within the continental European range of ssp. palustris. Results: There was no regional variation in wing or tail lengths among British Marsh Tits, indicating that all resident birds belong to ssp. dresseri. There was no evidence supporting the existence of ssp. palustris in northern England. British birds were significantly smaller than those from continental Europe, with proportionately shorter tails, consistent across all age and sex classes. Conclusion: All British Marsh Tits should be considered as ssp. dresseri, with ssp. palustris being limited to continental Europe. With no evidence of regional variation in size within Britain, reliable sexing methods based on biometrics could be applied in demographic studies throughout the country

Long-term woodland restoration on lowland farmland through passive rewilding

Natural succession of vegetation on abandoned farmland provides opportunities for passive rewilding to re-establish native woodlands, but in Western Europe the patterns and outcomes of vegetation colonisation are poorly known. We combine time series of field surveys and remote sensing (lidar and photogrammetry) to study woodland development on two farmland fields in England over 24 and 59 years respectively: the New Wilderness (2.1 ha) abandoned in 1996, and the Old Wilderness (3.9 ha) abandoned in 1961, both adjacent to ancient woodland. Woody vegetation colonisation of the New Wilderness was rapid, with 86% vegetation cover averaging 2.9 m tall after 23 years post-abandonment. The Old Wilderness had 100% woody cover averaging 13.1 m tall after 53 years, with an overstorey tree-canopy (≥ 8 m tall) covering 91%. By this stage, the structural characteristics of the Old Wilderness were approaching those of neighbouring ancient woodlands. The woody species composition of both Wildernesses differed from ancient woodland, being dominated by animal-dispersed pedunculate oak Quercus robur and berry-bearing shrubs. Tree colonisation was spatially clustered, with wind-dispersed common ash Fraxinus excelsior mostly occurring near seed sources in adjacent woodland and hedgerows, and clusters of oaks probably resulting from acorn hoarding by birds and rodents. After 24 years the density of live trees in the New Wilderness was 132/ha (57% oak), with 390/ha (52% oak) in the Old Wilderness after 59 years; deadwood accounted for 8% of tree stems in the former and 14% in the latter. Passive rewilding of these ‘Wilderness’ sites shows that closed-canopy woodland readily re-established on abandoned farmland close to existing woodland, it was resilient to the presence of herbivores and variable weather, and approached the height structure of older woods within approximately 50 years. This study provides valuable long-term reference data in temperate Europe, helping to inform predictions of the potential outcomes of widespread abandonment of agricultural land in this region

The effects of a decade of agri‐environment intervention in a lowland farm landscape on population trends of birds and butterflies

•1. Declines in farmland biodiversity remain evident despite over three decades of research and implementation of agri-environment schemes (AES). Although positive effects of AES are often demonstrated locally or in the short term, studies exploring longer term trends in biodiversity often show contradictory results. Evidence for the potential of AES to drive beneficial changes in populations remains sparse, especially for mobile taxa such as birds and butterflies. •2. We analysed the abundance of 12 widespread bird and 9 butterfly species from a 10-year study of AES intervention in a farmland landscape in southern England. We compared estimates of annual population growth rates from our study landscape with rates derived from large-scale national monitoring schemes in equivalent landscapes without substantial AES. •3. Species trends in our study landscape were frequently stable or increasing, in contrast to concurrent declining trends in equivalent landscapes without AES. These differences were significant for total abundance of granivorous species and for chaffinch Fringilla coelebs, blue tit Cyanistes caeruleus and great tit Parus major individually. For butterflies, differences in trends were significantly more positive for gatekeeper Pyronia tithonus and green-veined white Pieris napi, while small white P. rapae showed a trend that was significantly more negative in our study landscape. •4. Synthesis and applications. Our results demonstrate that, for some bird and butterfly species, the higher abundances associated with areas of AES uptake within a typical commercial farmland landscape can co-occur with positive or stable population trends over long time scales and that these trends can show significant differences from those in equivalent landscapes without substantial AES interventions. Our results suggest that previously observed inconsistencies in AES benefits may in part reflect a lack of long-term studies with accurate data on AES uptake and quality (i.e. successful implementation and management). Our results, thus, affirm the importance of delivering and monitoring high-quality AES options if the design and implementation of the next generation of AES is to achieve significant benefits for biodiversity