Open reduction and corrective ulnar osteotomy for missed radial head dislocations in children

The treatment of chronic radial head dislocation remains controversial. Open reduction of the radial head in combination with correction of malalignment with ulnar osteotomy can be the key to a good surgical result. Between 2001 and 2006, 9 (6 female, 3 male, average age 8.4 (5-11) years) patients were treated surgically for chronic radial head dislocation by one surgeon. The time between trauma and surgery was 7 (1.5-14) months. The procedure consisted of open reduction of the dislocated radial head and reconstruction of the annular ligament in combination with an ulnar osteotomy. An upper arm cast was applied with the forearm in neutral rotation for six weeks. Plates were removed in all patients. Clinical and radiological evaluation took place preoperatively and after an average of 23 (10-49) months. At radiograph 8/9 showed a reduced radial head; in one an anterior subluxation was seen. The range of motion remained the same in 4 patients who had a full range of motion preoperatively. In 2/5 patients with loss of range of motion preoperatively, improvement was seen. There were no serious surgical complications beside one infection. Open reduction and corrective ulnar osteotomy shows good results for missed radial head dislocations in children

Absolute dimensions of solar-type eclipsing binaries. EF Aquarii: a G0 test for stellar evolution models

Recent studies have shown that stellar chromospheric activity, and its effect on convective energy transport in the envelope, is most likely the cause of significant radius and temperature discrepancies between theoretical evolution models and observations. We aim to determine absolute dimensions and abundances for the solar-type detached eclipsing binary EF Aqr, and to perform a detailed comparison with results from recent stellar evolutionary models. uvby-beta standard photometry was obtained with the Stromgren Automatic Telescope. The broadening function formalism was applied on spectra observed with HERMES at the Mercator telescope in La Palma, to obtain radial velocity curves. Masses and radii with a precision of 0.6% and 1.0% respectively have been established for both components of EF Aqr. The active 0.956 M_sol secondary shows star spots and strong Ca II H and K emission lines. The 1.224 M_sol primary shows signs of activity as well, but at a lower level. An [Fe/H] abundance of 0.00+-0.10 is derived with similar abundances for Si, Ca, Sc, Ti, V, Cr, Co, and Ni. Solar calibrated evolutionary models such as Yonsei-Yale, Victoria-Regina and BaSTI isochrones and evolutionary tracks are unable to reproduce EF Aqr, especially for the secondary, which is 9% larger and 400 K cooler than predicted. Models adopting significantly lower mixing length parameters l/H_p remove these discrepancies, as seen in other solar type binaries. For the observed metallicity, Granada models with a mixing length of l/H_p=1.30 (primary) and 1.05 (secondary) reproduce both components at a common age of 1.5+-0.6 Gyr. Observations of EF Aqr suggests that magnetic activity, and its effect on envelope convection, is likely to be the cause of discrepancies in both radius and temperature, which can be removed by adjusting the mixing length parameter of the models downwards.Comment: 11 pages, 8 figures, accepted for publication by A&

The perturbed sublimation rim of the dust disk around the post-AGB binary IRAS08544-4431

Context: Post-Asymptotic Giant Branch (AGB) binaries are surrounded by stable dusty and gaseous disks similar to the ones around young stellar objects. Whereas significant effort is spent on modeling observations of disks around young stellar objects, the disks around post-AGB binaries receive significantly less attention, even though they pose significant constraints on theories of disk physics and binary evolution. Aims: We want to examine the structure of and phenomena at play in circumbinary disks around post-AGB stars. We continue the analysis of our near-infrared interferometric image of the inner rim of the circumbinary disk around IRAS08544-4431. We want to understand the physics governing this inner disk rim. Methods: We use a radiative transfer model of a dusty disk to reproduce simultaneously the photometry as well as the near-infrared interferometric dataset on IRAS08544-4431. The model assumes hydrostatic equilibrium and takes dust settling self-consistently into account. Results: The best-fit radiative transfer model shows excellent agreement with the spectral energy distribution up to mm wavelengths as well as with the PIONIER visibility data. It requires a rounded inner rim structure, starting at a radius of 8.25 au. However, the model does not fully reproduce the detected over-resolved flux nor the azimuthal flux distribution of the inner rim. While the asymmetric inner disk rim structure is likely to be the consequence of disk-binary interactions, the origin of the additional over-resolved flux remains unclear. Conclusions: As in young stellar objects, the disk inner rim of IRAS08544-4431 is ruled by dust sublimation physics. Additional observations are needed to understand the origin of the extended flux and the azimuthal perturbation at the inner rim of the disk.Comment: Accepted for publication in A&A, 13 figures, 13 page

A mid-IR interferometric survey with MIDI/VLTI: resolving the second-generation protoplanetary disks around post-AGB binaries

We present a mid-IR interferometric survey of the circumstellar environment of a specific class of post-Asymptotic Giant Branch (post-AGB) binaries. For this class the presence of a compact dusty disk has been postulated on the basis of various spatially unresolved measurements. Our interferometric survey was performed with the MIDI instrument on the VLTI. In total 19 different systems were observed using variable baseline configurations. Combining all the visibilities at a single wavelength at 10.7 micron, we fitted two parametric models to the data: a uniform disk (UD) and a ring model mimicking a temperature gradient. We compared our observables of the whole sample, with synthetic data computed from a grid of radiative transfer models of passively irradiated disks in hydrostatic equilibrium. These models are computed with a Monte Carlo code that has been widely applied to describe the structure of protoplanetary disks around young stellar objects (YSO). The spatially resolved observations show that the majority of our targets cluster closely together in the distance-independent size-colour diagram, and have extremely compact N-band emission regions. The typical uniform disk diameter of the N-band emission region is about 40 mass which corresponds to a typical brightness temperature of 400-600~K. The resolved objects display very similar characteristics in the interferometric observables and in the spectral energy distributions. Therefore, the physical properties of the disks around our targets must be similar. The grid of protoplanetary disk models covers very well the observed objects. Much like for young stars, the spatially resolved N-band emission region is determined by the hot inner rim of the disk. Continued comparisons between post-AGB and protoplanetary disks will help to understand grain growth and disk evolution processes,Comment: 30 pages, 21 figures, in press in Astronomy and Astrophysic

An interferometric study of the post-AGB binary 89 Herculis I Spatially resolving the continuum circumstellar environment at optical and near-IR wavelengths with the VLTI, NPOI, IOTA, PTI, and the CHARA Array

Binary post-AGB stars are interesting laboratories to study both the evolution of binaries as well as the structure of circumstellar disks. A multiwavelength high angular resolution study of the prototypical object 89 Herculis is performed with the aim of identifying and locating the different emission components seen in the SED. A large interferometric data set, collected over the past decade and covering optical and near-IR wavelengths, is analyzed with simple geometric models. Combining the interferometric constraints with the photometry and the optical spectra, we reassess the energy budget of the post-AGB star and its circumstellar environment. We report the first (direct) detection of a large (35-40%) optical circumstellar flux contribution and spatially resolve its emission region. Given this large amount of reprocessed and/or redistributed optical light, the fitted size of the emission region is rather compact and fits with(in) the inner rim of the circumbinary dust disk. This rim dominates our K band data through thermal emission and is rather compact, emitting significantly already at a radius of twice the orbital separation. We interpret the circumstellar optical flux as due to a scattering process, with the scatterers located in the extremely puffed-up inner rim of the disk and possibly also in a bipolar outflow seen pole-on. A non-LTE gaseous origin in an inner disk cannot be excluded but is considered highly unlikely. This direct detection of a significant amount of circumbinary light at optical wavelengths poses several significant questions regarding our understanding of both post-AGB binaries and the physics in their circumbinary disks. Although the identification of the source of emission/scattering remains inconclusive without further study on this and similar objects, the implications are manifold.Comment: Accepted for publication in A&A, 16 pages, 15 figure

ost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism

Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms associated with disease-causing genetic variants. The human 17β-hydroxysteroid dehydrogenase 10 (HSD10) is a moonlighting enzyme with at least two structurally and catalytically unrelated functions. HSD10 disease was originally described as a disorder of isoleucine metabolism, but the clinical manifestations were subsequently shown to be linked to impaired mtDNA transcript processing due to deficient function of HSD10 in the mtRNase P complex. A surprisingly large number of other, mostly enzymatic and potentially clinically relevant functions have been attributed to HSD10. Recently, HSD10 was reported to exhibit phospholipase C-like activity towards cardiolipins (CL), important mitochondrial phospholipids. To assess the physiological role of the proposed CL-cleaving function, we studied CL architectures in living cells and patient fibroblasts in different genetic backgrounds and lipid environments using our well-established LC–MS/MS cardiolipidomic pipeline. These experiments revealed no measurable effect on CLs, indicating that HSD10 does not have a physiologically relevant function towards CL metabolism. Evolutionary constraints could explain the broad range of reported substrates for HSD10 in vitro. The combination of an essential structural with a non-essential enzymatic function in the same protein could direct the evolutionary trajectory towards improvement of the former, thereby increasing the flexibility of the binding pocket, which is consistent with the results presented here

Class of self-limiting growth models in the presence of nonlinear diffusion

The source term in a reaction-diffusion system, in general, does not involve explicit time dependence. A class of self-limiting growth models dealing with animal and tumor growth and bacterial population in a culture, on the other hand are described by kinetics with explicit functions of time. We analyze a reaction-diffusion system to study the propagation of spatial front for these models.Comment: RevTex, 13 pages, 5 figures. To appear in Physical Review

Mathematical description of bacterial traveling pulses

The Keller-Segel system has been widely proposed as a model for bacterial waves driven by chemotactic processes. Current experiments on {\em E. coli} have shown precise structure of traveling pulses. We present here an alternative mathematical description of traveling pulses at a macroscopic scale. This modeling task is complemented with numerical simulations in accordance with the experimental observations. Our model is derived from an accurate kinetic description of the mesoscopic run-and-tumble process performed by bacteria. This model can account for recent experimental observations with {\em E. coli}. Qualitative agreements include the asymmetry of the pulse and transition in the collective behaviour (clustered motion versus dispersion). In addition we can capture quantitatively the main characteristics of the pulse such as the speed and the relative size of tails. This work opens several experimental and theoretical perspectives. Coefficients at the macroscopic level are derived from considerations at the cellular scale. For instance the stiffness of the signal integration process turns out to have a strong effect on collective motion. Furthermore the bottom-up scaling allows to perform preliminary mathematical analysis and write efficient numerical schemes. This model is intended as a predictive tool for the investigation of bacterial collective motion