Improvements in speech of children with apraxia: The efficacy of a Treatment for Establishing Motor Program Organization (TEMPO)

Childhood apraxia of speech (CAS) is a motor speech disorder characterized by distorted phonemes, segmentation (increased segment and intersegment durations), and impaired production of lexical stress. This study investigated the efficacy of Treatment for Establishing Motor Program Organization (TEMPO) in nine participants (ages 5 to 8) using a delayed treatment group design. Children received four weeks of intervention for four days each week. Experimental probes were administered at baseline and post-treatment—both immediately and one month after treatment—for treated and untreated stimuli. Significant improvements in specific acoustic measures of segmentation and lexical stress were demonstrated following treatment for both the immediate and delayed treatment groups. Treatment effects for all variables were maintained at one-month post-treatment. These results support the demonstrated efficacy of TEMPO in improving the speech of children with CAS

Généalogie de la critique d’Israël comme État d’apartheid : l’antisionisme de Durban

L’antisionisme qui a occupé le devant de la scène lors de la «Conférence mondiale contre le racisme » organisée par les Nations unies à Durban en 2001 n’était ni un « nouvel antisémitisme », ni la dernière manifestation d’un phénomène anhistorique et éternel. Durant la période des négociations de paix israélo-palestinienne, entre la fin des années 80 et les années 90, l’accent mis sur Israël comme représentant clé de tout ce qui est mauvais dans le monde était en voie de disparition, mais à Durban, l’équivalence courante dans les années 70 selon laquelle « sionisme = racisme » a refait surface. David Hirsh et Hilary Miller reviennent sur cet événement, lors duquel a été thématisée la critique, devenue depuis classique, d’Israël comme État d’apartheid

Discussion Group Report: Governmental Conduct

Governmental conduct\u27 covers behavior by a wide range of individuals, engaging in a broad scope of activities, and is addressed by a variety of statutes, rules, and codes of conduct. This report concerns the conduct of all persons occupying a position of public trust in New Mexico: elected officials, appointed officials, and classified and exempt state employees. All of these individuals owe important ethical duties to the citizens of New Mexico. Laws and rules regulating government conduct are largely concerned with 1) restrictions on the behavior of individual actors, and 2) disclosure and reporting of government activities so that those activities are open and transparent to the public. Regulations covering behavior restrictions and disclosure may be found in the Campaign Reporting Act, the Lobbyist Regulation Act, Senate and House ethical rules, agency policy manuals, the Governmental Conduct Act, the Open Meetings Act, the Procurement Code, the Financial Disclosure Act, the Personnel Act, NMAC personnel regulations, and the Inspection of Public Records Act. This list is not comprehensive. This report focuses on government conduct in the following issue areas drawn from the Task Force matrix: gifts, reporting, nepotism, honoraria, lobbying, and conduct of public officers and employees. Each of these subcategories will be considered separately.\u2

乳癌患者における極性タンパクPKCζ発現と化学療法耐性および予後との相関に対する研究

研究科: 千葉大学大学院医学薬学府学位:千大院医薬博甲第医1140号要約博士(医学)千葉大

De novo sequence assembly and characterisation of a partial transcriptome for an evolutionarily distinct reptile, the tuatara (Sphenodon punctatus)

BACKGROUND: The tuatara (Sphenodon punctatus) is a species of extraordinary zoological interest, being the only surviving member of an entire order of reptiles which diverged early in amniote evolution. In addition to their unique phylogenetic placement, many aspects of tuatara biology, including temperature-dependent sex determination, cold adaptation and extreme longevity have the potential to inform studies of genome evolution and development. Despite increasing interest in the tuatara genome, genomic resources for the species are still very limited. We aimed to address this by assembling a transcriptome for tuatara from an early-stage embryo, which will provide a resource for genome annotation, molecular marker development and studies of development and adaptation in tuatara. RESULTS: We obtained 30 million paired-end 50 bp reads from an Illumina Genome Analyzer and assembled them with Velvet and Oases using a range of kmers. After removing redundancy and filtering out low quality transcripts, our transcriptome dataset contained 32911 transcripts, with an N50 of 675 and a mean length of 451 bp. Almost 50% (15965) of these transcripts could be annotated by comparison with the NCBI non-redundant (NR) protein database or the chicken, green anole and zebrafish UniGene sets. A scan of candidate genes and repetitive elements revealed genes involved in immune function, sex differentiation and temperature-sensitivity, as well as over 200 microsatellite markers. CONCLUSIONS: This dataset represents a major increase in genomic resources for the tuatara, increasing the number of annotated gene sequences from just 60 to almost 16,000. This will facilitate future research in sex determination, genome evolution, local adaptation and population genetics of tuatara, as well as inform studies on amniote evolution

A self-management programme to reduce falls and improve safe mobility in people with secondary progressive MS: the BRiMS feasibility RCT

This is the final version, also available from NIHR journals library via the DOI in this record.Abstract Background Balance, mobility impairments and falls are common problems for people with multiple sclerosis (MS). Our ongoing research has led to the development of Balance Right in MS (BRiMS), a 13-week home- and group-based exercise and education programme intended to improve balance and encourage safer mobility. Objective This feasibility trial aimed to obtain the necessary data and operational experience to finalise the planning of a future definitive multicentre randomised controlled trial. Design Randomised controlled feasibility trial. Participants were block randomised 1 : 1. Researcher-blinded assessments were scheduled at baseline and at 15 and 27 weeks post randomisation. As is appropriate in a feasibility trial, statistical analyses were descriptive rather than involving formal/inferential comparisons. The qualitative elements utilised template analysis as the chosen analytical framework. Setting Four sites across the UK. Participants Eligibility criteria included having a diagnosis of secondary progressive MS, an Expanded Disability Status Scale (EDSS) score of between ≥ 4.0 and ≤ 7.0 points and a self-report of two or more falls in the preceding 6 months. Interventions Intervention – manualised 13-week education and exercise programme (BRiMS) plus usual care. Comparator – usual care alone. Main outcome measures Trial feasibility, proposed outcomes for the definitive trial (including impact of MS, mobility, quality of life and falls), feasibility of the BRiMS programme (via process evaluation) and economic data. Results A total of 56 participants (mean age 59.7 years, standard deviation 9.7 years; 66% female; median EDSS score of 6.0 points, interquartile range 6.0–6.5 points) were recruited in 5 months; 30 were block randomised to the intervention group. The demographic and clinical data were broadly comparable at baseline; however, the intervention group scored worse on the majority of baseline outcome measures. Eleven participants (19.6%) withdrew or were lost to follow-up. Worsening of MS-related symptoms unrelated to the trial was the most common reason (n = 5) for withdrawal. Potential primary and secondary outcomes and economic data had completion rates of > 98% for all those assessed. However, the overall return rate for the patient-reported falls diary was 62%. After adjusting for baseline score, the differences between the groups (intervention compared with usual care) at week 27 for the potential primary outcomes were MS Walking Scale (12-item) version 2 –7.7 [95% confidence interval (CI) –17.2 to 1.8], MS Impact Scale (29-item) version 2 (MSIS-29vs2) physical 0.6 (95% CI –7.8 to 9) and MSIS-29vs2 psychological –0.4 (95% CI –9.9 to 9) (negative score indicates improvement). After the removal of one outlier, a total of 715 falls were self-reported over the 27-week trial period, with substantial variation between individuals (range 0–93 falls). Of these 715 falls, 101 (14%) were reported as injurious. Qualitative feedback indicated that trial processes and participant burden were acceptable, and participants highlighted physical and behavioural changes that they perceived to result from undertaking BRiMS. Engagement varied, influenced by a range of condition- and context-related factors. Suggestions to improve the utility and accessibility of BRiMS were highlighted. Conclusions The results suggest that the trial procedures are feasible and acceptable, and retention, programme engagement and outcome completion rates were sufficient to satisfy the a priori progression criteria. Challenges were experienced in some areas of data collection, such as completion of daily diaries.National Institute for Health Research (NIHR

Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival

The effects of the adenovirus Ad5 on basic host cell programs, such as cell-cycle regulation, were studied in a microarray analysis of human fibroblasts. About 2,000 genes were up- or down-regulated after Ad5 infection and Ad5 infection was shown to induce reversal of the quiescence program and recapitulation of the core serum response