12 research outputs found
Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)
The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and
death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated
organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating
illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without
early treatment can succumb to delayed in-hospital
care and death. Prompt early initiation of sequenced multidrug
therapy (SMDT) is a widely and currently available
solution to stem the tide of hospitalizations and death. A
multipronged therapeutic approach includes 1) adjuvant
nutraceuticals, 2) combination intracellular anti-infective
therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet
agents/anticoagulants, 5) supportive care including supplemental
oxygen, monitoring, and telemedicine. Randomized
trials of individual, novel oral therapies have not
delivered tools for physicians to combat the pandemic in
practice. No single therapeutic option thus far has been
entirely effective and therefore a combination is required
at this time. An urgent immediate pivot from single drug to
SMDT regimens should be employed as a critical strategy
to deal with the large numbers of acute COVID-19 patients
with the aim of reducing the intensity and duration
of symptoms and avoiding hospitalization and death
Outcome and subsequent fertility of sheep and goats undergoing cesarean section because of dystocia: 110 cases (1981-2001)
The Efficacy of Hair and Urine Toxicology Screening on the Detection of Child Abuse by Burning
Releases, Distribution and Abundance of Gratiana boliviana
From 2003 to 2008, 176,643 Gratiana boliviana Spaeth (Coleoptera: Chrysomelidae) were released in Florida as part of a biological control program targeting tropical soda apple (TSA) Solanum viarum Dunal (Solanaceae). The spatial distribution of releases was clustered with more beetles released in south/central Florida than further north. A survey conducted in the fall of 2008 found G. bolviana present at \u3e70% of randomly selected locations between 26° and 29° latitude, but no beetles were found at sites further north. The presence of beetles and beetle damage were associated with smaller TSA plants and fewer fruits per plant. The absence of beetles in northern Florida may be due to the fewer number released in that area, but also could be influenced by land cover and climate