Limits on Superconductivity-Related Magnetization in Sr2_2RuO4_4 and PrOs4_4Sb12_{12} from Scanning SQUID Microscopy

We present scanning SQUID microscopy data on the superconductors Sr2RuO4 (Tc = 1.5 K) and PrOs$_4$Sb$_{12}$ (Tc = 1.8 K). In both of these materials, superconductivity-related time-reversal symmetry-breaking fields have been observed by muon spin rotation; our aim was to visualize the structure of these fields. However in neither Sr$_2$RuO$_4$ nor PrOs$_4$Sb$_{12}$ do we observe spontaneous superconductivity-related magnetization. In Sr$_2$RuO$_4$, many experimental results have been interpreted on the basis of a $px \pm ipy$ superconducting order parameter. This order parameter is expected to give spontaneous magnetic induction at sample edges and order parameter domain walls. Supposing large domains, our data restrict domain wall and edge fields to no more than ~0.1% and ~0.2% of the expected magnitude, respectively. Alternatively, if the magnetization is of the expected order, the typical domain size is limited to ~30 nm for random domains, or ~500 nm for periodic domains.Comment: 8 pages, 7 figures. Submitted to Phys. Rev.

Relationship between personality change and the onset and course of alcohol dependence in young adulthood

Aims  To examine the reciprocal effects between the onset and course of alcohol use disorder (AUD) and normative changes in personality traits of behavioral disinhibition and negative emotionality during the transition between adolescence and young adulthood. Design  Longitudinal–epidemiological study assessing AUD and personality at ages 17 and 24 years. Setting  Participants were recruited from the community and took part in a day‐long, in‐person assessment. Participants  Male ( n  = 1161) and female ( n  = 1022) twins participating in the Minnesota Twin Family Study. Measurements  The effects of onset (adolescent versus young adult) and course (persistent versus desistent) of AUD on change in personality traits of behavioral disinhibition and negative emotionality from ages 17 to 24 years. Findings  Onset and course of AUD moderated personality change from ages 17 to 24 years. Adolescent onset AUD was associated with greater decreases in behavioral disinhibition. Those with an adolescent onset and persistent course failed to exhibit normative declines in negative emotionality. Desistence was associated with a ‘recovery’ towards psychological maturity in young adulthood, while persistence was associated with continued personality dysfunction. Personality traits at age 11 predicted onset and course of AUD, indicating personality differences were not due to active substance abuse. Conclusions  Personality differences present prior to initiation of alcohol use increase risk for alcohol use disorder, but the course of alcohol use disorder affects the rate of personality change during emerging adulthood. Examining the reciprocal effects of personality and alcohol use disorder within a developmental context is necessary to improve understanding for theory and intervention.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90257/1/j.1360-0443.2011.03617.x.pd

Personality and Psychopathology: A Stagnant Field in Need of Development

A dominant paradigm in psychopathology research proposes that individual differences in personality are centrally involved in the origins and manifestations of psychopathology, and structural models of personality and psychopathology have been extremely useful in helping to organize associations among many traits and disorders. However, these models merely describe patterns of covariation; they do not explain the processes by which these patterns emerge. We argue that the field is stagnated, as it is overly focused on the demonstration of concurrent associations and on confirming a spectrum model that proposes traits and disorders are manifestations of the same underlying constructs. We contend that if the field is to move towards an understanding of causal processes, it must integrate knowledge and principles of personality development and developmental psychopathology. To begin this integration, we review (i) normative trends in personality change, (ii) age‐related changes in the prevalence of disorders, and (iii) the impact of onset and chronicity on the severity of disorders. We propose several developmental processes that may contribute to the co‐development of personality and psychopathology. We then present novel empirical findings to illustrate how a developmental perspective on traits and disorders can inform new hypotheses and propose principles and hypotheses that should guide future research. Copyright © 2014 European Association of Personality PsychologyPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108321/1/per1962.pd

The Segmented Aperture Interferometric Nulling Testbed (SAINT) III: Control Systems Analysis and Preliminary Results

This work presents a detailed current performance analysis for the telescope, pointing, and coronagraph com- ponent subsystems of the Segmented Aperture Interferometric Nulling Testbed (SAINT). The project pairs an active segmented mirror with the Visible Nulling Coronagraph (VNC) towards demonstrating capabilities for the future space observatories needed to directly detect and characterize Earth-sized worlds around nearby stars. We describe approaches to optimize subsystem wavefront sensing and control parameters, summarizing relevant scal- ing relations between these parameters, residual errors, and observed contrast measurements. Preliminary results from diagnostic testing under various control states are presented along with intermediate contrast measurements towards demonstrating the full system

Codevelopment Between Key Personality Traits and Alcohol Use Disorder From Adolescence Through Young Adulthood

ObjectivePersonality traits related to negative emotionality and low constraint are strong correlates of alcohol use disorder (AUD), but few studies have evaluated the prospective interplay between these traits and AUD symptoms from adolescence to young adulthood.MethodThe Minnesota Twin Family Study (N = 2,769) was used to examine the developmental interplay between AUD symptoms and three personality measures of constraint, negative emotionality, and aggressive undercontrol from ages 17 to 29.ResultsResults from random‐intercept, cross‐lagged panel models showed that low constraint and aggressive undercontrol predicted subsequent rank‐order increases in AUD symptoms from ages 17 to 24. AUD symptoms did not predict rank‐order change in these traits from ages 17 to 24. There was support for both cross‐effects from ages 24 to 29. Biometric analysis of the twin data showed genetic influences accounted for most of the phenotypic correlations over time.ConclusionResults are consistent with the notion that personality traits related to low constraint and aggressive undercontrol are important vulnerability/predisposition factors for the development of early adult AUD. In later young adulthood, there is more evidence for the simultaneous codevelopment of personality and AUD. Implications are addressed with attention to personality‐based risk assessments and targeted AUD prevention approaches.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142935/1/jopy12311.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142935/2/jopy12311_am.pd

The Global Phosphoproteome of Chlamydomonas reinhardtii Reveals Complex Organellar Phosphorylation in the Flagella and Thylakoid Membrane

Chlamydomonas reinhardtii is the most intensively-studied and well-developed model for investigation of a wide-range of microalgal processes ranging from basic development through understanding triacylglycerol production. Although proteomic technologies permit interrogation of these processes at the protein level and efforts to date indicate phosphorylation-based regulation of proteins in C. reinhardtii is essential for its underlying biology, characterization of the C. reinhardtii phosphoproteome has been limited. Herein, we report the richest exploration of the C. reinhardtii proteome to date. Complementary enrichment strategies were used to detect 4588 phosphoproteins distributed among every cellular component in C. reinhardtii. Additionally, we report 18,160 unique phosphopeptides at <1% false discovery rate, which comprise 15,862 unique phosphosites - 98% of which are novel. Given that an estimated 30% of proteins in a eukaryotic cell are subject to phosphorylation, we report the majority of the phosphoproteome (23%) of C. reinhardtii. Proteins in key biological pathways were phosphorylated, including photosynthesis, pigment production, carbon assimilation, glycolysis, and protein and carbohydrate metabolism, and it is noteworthy that hyperphosphorylation was observed in flagellar proteins. This rich data set is available via ProteomeXchange (ID: PXD000783) and will significantly enhance understanding of a range of regulatory mechanisms controlling a variety of cellular process and will serve as a critical resource for the microalgal community

Chandra Observations of the Cl1604 Supercluster at z=0.9: Evidence for an Overdensity of Active Galactic Nuclei

We present the results of Chandra observations of the Cl1604 supercluster at z~0.9. The system is the largest structure mapped at redshifts approaching unity, containing at least eight spectroscopically confirmed galaxy clusters and groups. Using two 50-ksec ACIS-I pointings we examine both the X-ray point source population and the diffuse emission from individual clusters in the system. We find a 2.5\sigma excess of point sources detected in the hard band (2-10 keV) relative to the number of sources found in blank fields observed by Chandra. No such excess is observed in the soft band (0.5-2 keV). The hard-band source density is 1.47 times greater than that of a blank field, in agreement with the previously reported correlation between overdensity amplitude and cluster redshift. Using a maximum likelihood technique we have matched 112 of the 161 detected X-ray point sources to optical counterparts and found 15 sources that are associated with the supercluster. All 15 sources have rest-frame luminosities consistent with emission from active galactic nuclei (AGN). We find that the supercluster AGN largely avoid the densest regions of the system and are instead distributed on the outskirts of massive clusters or within poorer clusters and groups. We have also detected diffuse emission from two of the eight clusters and groups in the system, clusters Cl1604+4304 and Cl1604+4314. The systems have bolometric luminosities of 1.43x10^44 and 8.20x10^43 h70^-2 erg s^-1 and gas temperatures of 3.50 (+1.82-1.08) and 1.64 (+0.65-0.45) keV, respectively. Using updated velocity dispersions, we compare the properties of these systems to the cluster scaling relations followed by other X-ray and optically selected galaxy clusters at high redshift.Comment: 24 pages, 14 figures, submitted to Ap