Solar variability indications from Nimbus 7 satellite data

The cavity pyrheliometer sensor of the Nimbus 7 Earth Radiation Experiment indicated low-level variability of the total solar irradiance. The variability appears to be inversely correlated with common solar activity indicators in an event sense. the limitations of the measuring system and available data sets are described

Larval dispersal in a changing ocean with an emphasis on upwelling regions

Dispersal of benthic species in the sea is mediated primarily through small, vulnerable larvae that must survive minutes to months as members of the plankton community while being transported by strong, dynamic currents. As climate change alters ocean conditions, the dispersal of these larvae will be affected, with pervasive ecological and evolutionary consequences. We review the impacts of oceanic changes on larval transport, physiology, and behavior. We then discuss the implications for population connectivity and recruitment and evaluate life history strategies that will affect susceptibility to the effects of climate change on their dispersal patterns, with implications for understanding selective regimes in a future ocean. We find that physical oceanographic changes will impact dispersal by transporting larvae in different directions or inhibiting their movements while changing environmental factors, such as temperature, pH, salinity, oxygen, ultraviolet radiation, and turbidity, will affect the survival of larvae and alter their behavior. Reduced dispersal distance may make local adaptation more likely in well-connected populations with high genetic variation while reduced dispersal success will lower recruitment with implications for fishery stocks. Increased dispersal may spur adaptation by increasing genetic diversity among previously disconnected populations as well as increasing the likelihood of range expansions. We hypothesize that species with planktotrophic (feeding), calcifying, or weakly swimming larvae with specialized adult habitats will be most affected by climate change. We also propose that the adaptive value of retentive larval behaviors may decrease where transport trajectories follow changing climate envelopes and increase where transport trajectories drive larvae toward increasingly unsuitable conditions. Our holistic framework, combined with knowledge of regional ocean conditions and larval traits, can be used to produce powerful predictions of expected impacts on larval dispersal as well as the consequences for connectivity, range expansion, or recruitment. Based on our findings, we recommend that future studies take a holistic view of dispersal incorporating biological and oceanographic impacts of climate change rather than solely focusing on oceanography or physiology. Genetic and paleontological techniques can be used to examine evolutionary impacts of altered dispersal in a future ocean, while museum collections and expedition records can inform modern-day range shifts

Phosphorylation: The Molecular Switch of Double-Strand Break Repair

Repair of double-stranded breaks (DSBs) is vital to maintaining genomic stability. In mammalian cells, DSBs are resolved in one of the following complex repair pathways: nonhomologous end-joining (NHEJ), homologous recombination (HR), or the inclusive DNA damage response (DDR). These repair pathways rely on factors that utilize reversible phosphorylation of proteins as molecular switches to regulate DNA repair. Many of these molecular switches overlap and play key roles in multiple pathways. For example, the NHEJ pathway and the DDR both utilize DNA-PK phosphorylation, whereas the HR pathway mediates repair with phosphorylation of RPA2, BRCA1, and BRCA2. Also, the DDR pathway utilizes the kinases ATM and ATR, as well as the phosphorylation of H2AX and MDC1. Together, these molecular switches regulate repair of DSBs by aiding in DSB recognition, pathway initiation, recruitment of repair factors, and the maintenance of repair mechanisms

Diffusive and ballistic current spin-polarization in magnetron-sputtered L1o-ordered epitaxial FePt

We report on the structural, magnetic, and electron transport properties of a L1o-ordered epitaxial iron-platinum alloy layer fabricated by magnetron-sputtering on a MgO(001) substrate. The film studied displayed a long range chemical order parameter of S~0.90, and hence has a very strong perpendicular magnetic anisotropy. In the diffusive electron transport regime, for temperatures ranging from 2 K to 258 K, we found hysteresis in the magnetoresistance mainly due to electron scattering from magnetic domain walls. At 2 K, we observed an overall domain wall magnetoresistance of about 0.5 %. By evaluating the spin current asymmetry alpha = sigma_up / sigma_down, we were able to estimate the diffusive spin current polarization. At all temperatures ranging from 2 K to 258 K, we found a diffusive spin current polarization of > 80%. To study the ballistic transport regime, we have performed point-contact Andreev-reflection measurements at 4.2 K. We obtained a value for the ballistic current spin polarization of ~42% (which compares very well with that of a polycrystalline thin film of elemental Fe). We attribute the discrepancy to a difference in the characteristic scattering times for oppositely spin-polarized electrons, such scattering times influencing the diffusive but not the ballistic current spin polarization.Comment: 22 pages, 13 figure

Multi-Instrumented Observations of the Equatorial F-Region During June Solstice: Large-Scale Wave Structures and Spread-F

Typical equatorial spread-F events are often said to occur during post-sunset, equinox conditions in most longitude sectors. Recent studies, however, have found an unexpected high occurrence of ionospheric F-region irregularities during June solstice, when conditions are believed to be unfavorable for the development of plasma instabilities responsible for equatorial spread-F (ESF). This study reports new results of a multi-instrumented investigation with the objective to better specify the occurrence of these atypical June solstice ESF in the American sector and better understand the conditions prior to their development. We present the first observations of June solstice ESF events over the Jicamarca Radio Observatory (11.95° S, 76.87° W, ∼ 1° dip latitude) made by a 14-panel version of the Advanced Modular Incoherent Scatter Radar system (AMISR-14). The observations were made between July 11 and August 4, 2016, under low solar flux conditions and in conjunction with dual-frequency GPS, airglow, and digisonde measurements. We found echoes occurring in the pre-, post-, and both pre- and post-midnight sectors. While at least some of these June solstice ESF events could have been attributed to disturbed electric fields, a few events also occurred during geomagnetically quiet conditions. The late appearance (22:00 LT or later) of three of the observed events, during clear-sky nights, provided a unique opportunity to investigate the equatorial bottomside F-region conditions, prior to ESF, using nighttime airglow measurements. We found that the airglow measurements (630 nm) made by a collocated all-sky camera show the occurrence of ionospheric bottomside F-region perturbations prior to the detection of ESF echoes in all three nights. The airglow fluctuations appear as early as 1 hour prior to radar echoes, grow in amplitude, and then coincide with ESF structures observed by AMISR-14 and GPS TEC measurements. They also show some of the features of the so-called large-scale wave structures (LSWS) that have been detected, previously, using other types of observations and have been suggested to be precursors of ESF. The bottomside fluctuations have zonal spacings between 300 and 500 km, are aligned with the magnetic meridian, and extend at least a few degrees in magnetic latitude

Pulsed rotating supersonic source used with merged molecular beams

We describe a pulsed rotating supersonic beam source, evolved from an ancestral device [M. Gupta and D. Herschbach, J. Phys. Chem. A 105, 1626 (2001)]. The beam emerges from a nozzle near the tip of a hollow rotor which can be spun at high-speed to shift the molecular velocity distribution downward or upward over a wide range. Here we consider mostly the slowing mode. Introducing a pulsed gas inlet system, cryocooling, and a shutter gate eliminated the main handicap of the original device, in which continuous gas flow imposed high background pressure. The new version provides intense pulses, of duration 0.1-0.6 ms (depending on rotor speed) and containing ~10^12 molecules at lab speeds as low as 35 m/s and ~ 10^15 molecules at 400 m/s. Beams of any molecule available as a gas can be slowed (or speeded); e.g., we have produced slow and fast beams of rare gases, O2, Cl2, NO2, NH3, and SF6. For collision experiments, the ability to scan the beam speed by merely adjusting the rotor is especially advantageous when using two merged beams. By closely matching the beam speeds, very low relative collision energies can be attained without making either beam very slow.Comment: 26 pages, 10 figure

The role of the alloy structure in the magnetic behavior of granular systems

The effect of grain size, easy magnetization axis and anisotropy constant distributions in the irreversible magnetic behavior of granular alloys is considered. A simulated granular alloy is used to provide a realistic grain structure for the Monte Carlo simulation of the ZFC-FC curves. The effect of annealing and external field is also studied. The simulation curves are in good agreement with the FC and ZFC magnetization curves measured on melt spun Cu-Co ribbons.Comment: 13 pages, 10 figures, submitted to PR

Understanding the errors of SHAPE-directed RNA structure modeling

Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms. Recent tests have shown that selective 2'-hydroxyl acylation by primer extension (SHAPE) can give near-zero error rates (0-2%) in modeling the helices of RNA secondary structure. Here, we benchmark the method using six molecules for which crystallographic data are available: tRNA(phe) and 5S rRNA from Escherichia coli, the P4-P6 domain of the Tetrahymena group I ribozyme, and ligand-bound domains from riboswitches for adenine, cyclic di-GMP, and glycine. SHAPE-directed modeling of these highly structured RNAs gave an overall false negative rate (FNR) of 17% and a false discovery rate (FDR) of 21%, with at least one helix prediction error in five of the six cases. Extensive variations of data processing, normalization, and modeling parameters did not significantly mitigate modeling errors. Only one varation, filtering out data collected with deoxyinosine triphosphate during primer extension, gave a modest improvement (FNR = 12%, and FDR = 14%). The residual structure modeling errors are explained by the insufficient information content of these RNAs' SHAPE data, as evaluated by a nonparametric bootstrapping analysis. Beyond these benchmark cases, bootstrapping suggests a low level of confidence (<50%) in the majority of helices in a previously proposed SHAPE-directed model for the HIV-1 RNA genome. Thus, SHAPE-directed RNA modeling is not always unambiguous, and helix-by-helix confidence estimates, as described herein, may be critical for interpreting results from this powerful methodology.Comment: Biochemistry, Article ASAP (Aug. 15, 2011

Impurity Scattering from δ\delta-layers in Giant Magnetoresistance Systems

The properties of the archetypal Co/Cu giant magnetoresistance (GMR) spin-valve structure have been modified by the insertion of very thin (sub-monolayer) $\delta$-layers of various elements at different points within the Co layers, and at the Co/Cu interface. Different effects are observed depending on the nature of the impurity, its position within the periodic table, and its location within the spin-valve. The GMR can be strongly enhanced or suppressed for various specific combinations of these parameters, giving insight into the microscopic mechanisms giving rise to the GMR.Comment: 5 pages, 2 figure