404 research outputs found
Déterminants nutritionnels précoces du neurodéveloppement des enfants de l'étude EDEN (rÎle des acides gras polyinsaturés)
Contexte : De la conception Ă l Ăąge adulte, de nombreux dĂ©terminants environnementaux influencent le neurodĂ©veloppement. Des Ă©tudes montrent que durant la fin de la grossesse et les premiers mois de vie, une grande quantitĂ© d acides gras polyinsaturĂ©s (AGPI), notamment Ă longue chaĂźne (AGPI-LC), se fixe dans le tissu cĂ©rĂ©bral. Un apport optimal durant ces pĂ©riodes critiques pourrait soutenir prĂ©cocement le bon dĂ©veloppement du cerveau et de ses fonctions.Objectifs : Ătudier les relations entre les expositions prĂ©- et postnatales prĂ©coces aux AGPI, et le neurodĂ©veloppement d enfants de 2 et 3 ans.Population : Les donnĂ©es utilisĂ©es Ă©taient celles de l Ă©tude EDEN, une cohorte mĂšre enfant ayant recrutĂ© 2002 femmes enceintes dans les maternitĂ©s de Nancy et Poitiers entre 2003 et 2006. L alimentation maternelle pendant la grossesse a Ă©tĂ© Ă©valuĂ©e par un questionnaire de frĂ©quence alimentaire et une table de composition nutritionnelle. Quatre questionnaires postnatals ont permis d Ă©valuer la durĂ©e d allaitement maternel, et la composition lipidique du colostrum des mĂšres allaitantes a Ă©tĂ© analysĂ©e par chromatographie en phase gazeuse. Des questionnaires parentaux (2 et 3 ans) et un examen neuropsychologique (3 ans) ont permis d Ă©valuer plusieurs aspects du neurodĂ©veloppement. Les analyses statistiques ont Ă©tĂ© rĂ©alisĂ©es par rĂ©gressions linĂ©aires multivariĂ©es, aprĂšs ajustement sur de nombreux facteurs de confusion potentiels.RĂ©sultats : Les scores de neurodĂ©veloppement Ă 2 et 3 ans des enfants allaitĂ©s Ă©taient plus Ă©levĂ©s que ceux des enfants non allaitĂ©s. Chez les enfants allaitĂ©s, la durĂ©e d allaitement maternel Ă©tait associĂ©e positivement au neurodĂ©veloppement. Le rapport n 6/n 3 dans l alimentation maternelle en acides gras en fin de grossesse Ă©tait nĂ©gativement associĂ© Ă plusieurs mesures du neurodĂ©veloppement, et cette association Ă©tait renforcĂ©e chez les enfants non allaitĂ©s. La composition du colostrum en AGPI et en AGPI-LC reflĂ©tait amplement les apports nutritionnels en AGPI et en AGPI-LC en fin de grossesse. L utilisation de matiĂšres grasses alimentaires Ă©tait aussi associĂ©e Ă la composition du colostrum. Les diffĂ©rences de neurodĂ©veloppement des enfants allaitĂ©s ne semblait pas ĂȘtre expliquĂ©es par la composition du colostrum en AGPI ni en AGPI-LC, Ă l exception de la teneur en acide linolĂ©ique qui Ă©tait nĂ©gativement associĂ©e Ă certaines mesures du neurodĂ©veloppement. Dans l ensemble, les associations avec le neurodĂ©veloppement Ă©taient plus frĂ©quemment retrouvĂ©es avec les questionnaires parentaux, mais certaines Ă©valuations par les psychologues venaient parfois conforter ces rĂ©sultats.Conclusion : AssociĂ©s Ă ceux de la littĂ©rature, ces rĂ©sultats soulignent le rĂŽle notable des AGPI durant les pĂ©riodes prĂ©- et postnatale prĂ©coce pour le neurodĂ©veloppement de l enfant. Le suivi des enfants de l Ă©tude EDEN jusqu Ă leur 5 ans permettra d Ă©tudier la persistance de ces rĂ©sultats. Dans une perspective de santĂ© publique, ces travaux rappellent la nĂ©cessitĂ© de promouvoir l allaitement maternel dans la durĂ©e et de surveiller l Ă©quilibre des apports nutritionnels en AGPI pendant la grossesse et la pĂ©riode de lactation.Context: From conception to adulthood, many environmental determinants influence neurodevelopment. Studies showed that in late pregnancy and the first months of life, a large amount of polyunsaturated fatty acids (PUFA), especially long-chain-PUFA (LCPUFA), accretes in the brain. Optimal intake during these critical periods could support the brain development and its cognitive functions.Aims: To investigate the relationships between pre- and early postnatal exposures to PUFA, and neurodevelopment of 2 and 3 years old children.Population: Data were those from the EDEN mother-child cohort study, in which 2002 pregnant women were recruited between 2003 and 2006 in the maternities of Nancy and Poitiers. Maternal food intake during pregnancy was evaluated by food frequency questionnaire combined with a food composition table. Duration of breastfeeding was assessed by 4 postnatal questionnaires. Lipids in colostrum of breastfeeding mothers were analyzed by gas chromatography. Several aspects of the cognitive and motor development were assessed by both parental questionnaires (2 and 3 y) and neuropsychological examination (3 y). Statistical analyzes were performed by multiple linear regressions, after adjusting for many potential confounders.Results: At 2 and 3 years, scores of neurodevelopment were higher among breastfed children than among never breastfed children. Among breastfed children, breastfeeding duration was positively associated with neurodevelopment. Maternal dietary n 6/n 3 ratio during late pregnancy was negatively associated with measures of neurodevelopment, and this association was reinforced among never breastfed children. Colostrum composition in PUFA and LCPUFA greatly reflected maternal intake during pregnancy. Use of oils/fats for cooking and seasoning was associated with colostrum composition. The differences of neurodevelopment of breastfed children did not seem to be explained by PUFA nor LCPUFA in colostrum, except for total linoleic acid that was negatively associated with some measures of neurodevelopment. In general, associations with neurodevelopment were more frequently found with assessments by parental questionnaires, but measures by psychologists sometimes confirmed the results.Conclusion: Combined with the literature, these results underline the importance of PUFA exposures during pre- and postnatal periods for the child neurodevelopment. Follow-up of children up to 5 years will allow to investigate whether those results persist later in childhood. From a public health perspectives, this work reiterates the need to promote breastfeeding duration and to monitor the balance of PUFA intake during pregnancy and lactation periods.PARIS11-SCD-Bib. Ă©lectronique (914719901) / SudocSudocFranceF
Associations between Children's Genetic Susceptibility to Obesity, Infant's Appetite and Parental Feeding Practices in Toddlerhood.
Previous findings suggest that parental feeding practices may adapt to children's eating behavior and sex, but few studies assessed these associations in toddlerhood. We aimed to study the associations between infant's appetite or children's genetic susceptibility to obesity and parental feeding practices. We assessed infant's appetite (three-category indicator: low, normal or high appetite, labelled 4-to-24-month appetite) and calculated a combined obesity risk-allele score (genetic risk score of body mass index (BMI-GRS)) in a longitudinal study of respectively 1358 and 932 children from the EDEN cohort. Parental feeding practices were assessed at 2-year-follow-up by the CFPQ. Three of the five tested scores were used as continuous variables; others were considered as binary variables, according to the median. Associations between infant's appetite or child's BMI-GRS and parental feeding practices were assessed by linear and logistic regression models, stratified on child's sex if interactions were significant. 4-to-24-month appetite was positively associated with restrictive feeding practices among boys and girls. Among boys, high compared to normal 4-to-24-month appetite was associated with higher use of food to regulate child's emotions (OR [95% CI] = 2.24 [1.36; 3.68]). Child's BMI-GRS was not related to parental feeding practices. Parental feeding practices may adapt to parental perception of infant's appetite and child's sex
Measuring Child Socio-Economic Position in Birth Cohort Research: The Development of a Novel Standardized Household Income Indicator
The assessment of early life socioeconomic position (SEP) is essential to the tackling of social inequalities in health. Although different indicators capture different SEP dimensions, maternal education is often used as the only indicator in birth cohort research, especially in multi-cohort analyses. Household income, as a direct measure of material resources, is one of the most important indicators, but one that is underused because it is difficult to measure through questionnaires. We propose a method to construct a standardized, cross-cohort comparable income indicator, the âEquivalized Household Income Indicator (EHII)â, which measures the equivalized disposable household income, using external data from the pan-European Union Statistics on Income and Living Conditions (EUSILC) surveys, and data from the cohorts. We apply this method to four studies, PiccolipiĂč and NINFEA from Italy and ELFE and EDEN from France, comparing the distribution of EHII with other SEP-related variables available in the cohorts, and estimating the association between EHII and child body mass index (BMI). We found that basic parental and household characteristics may be used, with a fairly good performance, to predict the household income. We observed a strong correlation between EHII and both the self-reported income, whenever available, and other individual socioeconomic-related variables, and an inverse association with child BMI. EHII could contribute to improving research on social inequalities in health, in particular in the context of European birth cohort collaborative studies
Associations between genetic obesity susceptibility and early postnatal fat and lean mass: an individual participant meta-analysis
IMPORTANCE: Patterns of body size and body composition associated with genetic obesity susceptibility inform the mechanisms that increase obesity risk. OBJECTIVE: To test associations between genetic obesity susceptibility, represented by a combined obesity risk-allele score, and body size or body composition at birth to age 5 years. DESIGN, SETTING, AND PARTICIPANTS: A total of 3031 children from 4 birth cohort studies in England, France, and Spain were included in a meta-analysis. EXPOSURES: A combined obesity risk-allele score was calculated from genotypes at 16 variants identified by genome-wide association studies of adult body mass index (BMI). MAIN OUTCOMES AND MEASURES: Outcomes were age- and sex-adjusted SD scores (SDS) for weight, length/height, BMI, fat mass, lean mass, and percentage of body fat at birth as well as at ages 1, 2 to 3, and 4 to 5 years. RESULTS: The obesity risk-allele score was not associated with infant size at birth; at age 1 year it was positively associated with weight (ÎČ [SE], 0.020 [0.008] SDS per allele; Pâ=â.009) and length (ÎČ [SE], 0.020 [0.008] SDS per allele; Pâ=â.01), but not with BMI (ÎČ [SE], 0.013 [0.008] SDS per allele; Pâ=â.11). At age 2 to 3 years these associations were stronger (weight: ÎČ [SE], 0.033 [0.008] SDS per allele; Pââ.15 at all ages). CONCLUSIONS AND RELEVANCE: Genetic obesity susceptibility appears to promote a normally partitioned increase in early postnatal, but not prenatal, growth. These findings suggest that symmetrical rapid growth may identify infants with high life-long susceptibility for obesity
Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review
There are over 1,000,000 publications on diet and health and over 480,000 references on inflammation in the National Library of Medicine database. In addition, there have now been over 30,000 peer-reviewed articles published on the relationship between diet, inflammation, and health outcomes. Based on this voluminous literature, it is now recognized that low-grade, chronic systemic inflammation is associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory and musculoskeletal disorders, as well as impaired neurodevelopment and adverse mental health outcomes. Dietary components modulate inflammatory status. In recent years, the Dietary Inflammatory Index (DIIÂź), a literature-derived dietary index, was developed to characterize the inflammatory potential of habitual diet. Subsequently, a large and rapidly growing body of research investigating associations between dietary inflammatory potential, determined by the DII, and risk of a wide range of NCDs has emerged. In this narrative review, we examine the current state of the science regarding relationships between the DII and cancer, cardiometabolic, respiratory and musculoskeletal diseases, neurodevelopment, and adverse mental health outcomes. We synthesize the findings from recent studies, discuss potential underlying mechanisms, and look to the future regarding novel applications of the adult and childrenâs DII (C-DII) scores and new avenues of investigation in this field of nutritional research
Recommended from our members
Association between genetic obesity susceptibility and mother-reported eating behaviour in children up to 5Â years.
BACKGROUND: Many genetic polymorphisms identified by genome-wide association studies for adult body mass index (BMI) have been suggested to regulate food intake. OBJECTIVE: The objective was to study the associations between a genetic obesity risk score, appetitive traits, and growth of children up to age 5 years, with a longitudinal design. METHODS: In 1142 children from the Etude des DĂ©terminants pre et post natals de la santĂ© de l'ENfant (EDEN) birth cohort, a combined obesity risk-allele score (BMI genetic risk score [GRS]) was related to appetitive traits (energy intake up to 12 mo, a single item on appetite from 4 mo to 3 y, a validated appetite score at 5 y) using Poisson regressions with robust standard errors. The potential mediation of appetitive traits on the association between BMI-GRS and growth was assessed by the Sobel test. RESULTS: Children with a high BMI-GRS were more likely to have high energy intake at 1 year and high appetite at 2 and 5 years. High energy intake in infancy and high appetite from 1 year were related to higher subsequent BMI. High 2-year appetite seemed to partially mediate the associations between BMI-GRS and BMI from 2 to 5 years (all P â€Â 0.05). CONCLUSIONS: Genetic susceptibility to childhood obesity seems to be partially explained by appetitive traits in infancy, followed by an early childhood rise in BMI.The EDEN study is supported by Fondation pour la Recherche MĂ©dicale (FRM), French Ministry of Research: Federative Research Institutes and Cohort Program, INSERM Human Nutrition National Research Program, and Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients [AFD]), French Ministry of Health, French Agency for Environment Security (AFSSET), French National Institute for Population Health Surveillance (InVS), ParisâSud University, French National Institute for Health Education (INPES), NestlĂ©, Mutuelle GĂ©nĂ©rale de l'Education Nationale (MGEN), Frenchâspeaking Association for the Study of Diabetes and Metabolism (ALFEDIAM), National Agency for Research (ANR nonâthematic programme), and National Institute for Research in Public Health (IRESP: TGIR 2008 cohort in health programme). The genotyping was funded by a Collaborative Research Grant from the European Society for Paediatric Endocrinology. K.K.O. is supported by the Medical Research Council (unit program: MC_UU_12015/2)
Parental lifestyle patterns around pregnancy and risk of childhood obesity in four European birth cohort studies
Maternal pre-pregnancy obesity and offspring hyperactivity-inattention symptoms at 5 years in preterm and term children: a multi-cohort analysis
The objective of this study was to determine the relationship between maternal pre-pregnancy body mass index (BMI) and child hyperactivity-inattention symptoms (HIS) at 5 years, including preterm and term-born children, and to determine whether this association varied with gestational age. Maternal pre-pregnancy BMI and offspring HIS were assessed in 10,898 participants born >/= 33 weeks of gestation from the ELFE cohort and 2646 children born between 23 and 34 weeks from the EPIPAGE 2 cohort. Reported pre-pregnancy weight (kg) and measured height (m) were collected from mothers at inclusion and used to classify BMI (kg/m(2)). Child HIS were evaluated using the Strengths and Difficulties Questionnaire around 5 years of age. Logistic regression estimated odds ratios (OR) of a high HIS score (>/= 90th percentile) in the ELFE cohort and generalized estimated equations were used in EPIPAGE 2 to account for non-independence of multiple births. As a negative control, paternal BMI was also considered as an exposure of interest in sensitivity analyses. Maternal pre-pregnancy obesity and overweight were associated with child HIS at 5 years in ELFE (adjusted OR [aOR] for obesity 1.27 [1.06, 1.53]; overweight aOR 1.16 [1.00, 1.36]) and pre-pregnancy obesity was associated with high HIS scores in preterm infants of EPIPAGE 2 (aOR 1.48 [1.06, 2.08]). In ELFE, the magnitude of the association increased with decreasing gestational age (interaction p = 0.02). High maternal pre-pregnancy BMI is associated with greater likelihood of high HIS scores in both at-term and preterm children at 5 years of age.Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssanceMaladie Rénale Chronique - Réseau Epidémiologie et Information en Néphrologi
Association between perinatal factors, genetic susceptibility to obesity and age at adiposity rebound in children of the EDEN motherâchild cohort
Abstract: Background: Early adiposity rebound (AR) has been associated with increased risk of overweight or obesity in adulthood. However, little is known about early predictors of age at AR. We aimed to study the role of perinatal factors and genetic susceptibility to obesity in the kinetics of AR. Methods: Body mass index (BMI) curves were modelled by using mixed-effects cubic models, and age at AR was estimated for 1415 children of the EDEN motherâchild cohort study. A combined obesity risk-allele score was calculated from genotypes for 27 variants identified by genome-wide association studies of adult BMI. Perinatal factors of interest were maternal age at delivery, parental education, parental BMI, gestational weight gain, maternal smoking during pregnancy, and newborn characteristics (sex, prematurity, and birth weight). We used a hierarchical level approach with multivariable linear regression model to investigate the association between these factors, obesity risk-allele score, and age at AR. Results: A higher genetic susceptibility to obesity score was associated with an earlier age at AR. At the most distal level of the hierarchical model, maternal and paternal educational levels were positively associated with age at AR. Children born to parents with higher BMI were more likely to exhibit earlier age at AR. In addition, higher gestational weight gain was related to earlier age at AR. For children born small for gestational age, the average age at AR was 88 [±39] days lower than for children born appropriate for gestational age and 91 [±56] days lower than for children born large for gestational age. Conclusion: The timing of AR seems to be an early childhood manifestation of the genetic susceptibility to adult obesity. We further identified low birth weight and gestational weight gain as novel predictors of early AR, highlighting the role of the intrauterine environment in the kinetics of adiposity
Impact of parental lifestyle patterns in the preconception and pregnancy periods on childhood obesity
International audienceIntroduction High prevalence of overweight and obesity already observed in preschool children suggests the involvement of early-life risk factors. Preconception period and pregnancy are crucial windows for the implementation of child obesity prevention interventions with parental lifestyle factors as relevant targets. So far, most studies have evaluated their role separately, with only a few having investigated their potential synergistic effect on childhood obesity. Our objective was to investigate parental lifestyle patterns in the preconception and pregnancy periods and their association with the risk of child overweight after 5âyears. Materials and methods We harmonized and interpreted results from four European mother-offspring cohorts participating in the EndObesity Consortium [EDEN, France; Elfe, France; Lifeways, Ireland; and Generation R, Netherlands] with data available for 1,900, 18,000, 1,100, and 9,500 families, respectively. Lifestyle factors were collected using questionnaires and included parental smoking, body mass index (BMI), gestational weight gain, diet, physical activity, and sedentary behavior. We applied principal component analyses to identify parental lifestyle patterns in preconception and pregnancy. Their association with risk of overweight (including obesity; OW-OB) and BMI z -scores between 5 and 12âyears were assessed using cohort-specific multivariable logistic and linear and regression models (adjusted for potential confounders including parental age, education level, employment status, geographic origin, parity, and household income). Results Among the various lifestyle patterns derived in all cohorts, the two explaining the most variance were characterized by (1) âhigh parental smoking, low maternal diet quality (and high maternal sedentary behavior in some cohorts)â and, (2) âhigh parental BMI and low gestational weight gain.â Patterns characterized by high parental BMI, smoking, low diet quality or high sedentary lifestyle before or during pregnancy were associated with higher risk of OW-OB in children, and BMI z -score at any age, with consistent strengths of associations in the main cohorts, except for lifeways. Conclusion This project provides insight into how combined parental lifestyle factors in the preconception and pregnancy periods are associated with the future risk of child obesity. These findings are valuable to inform family-based and multi-behavioural child obesity prevention strategies in early life
- âŠ