32 research outputs found

    3D-Modellierung mit interaktiven Oberflächen

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    3D models are at the core of many important applications from industry, science, and also entertainment. The creation of 3D models is a complex and time consuming process. Current modeling tools are hard to learn and require a deep understanding of the underlying mathematical models. Furthermore, established input devices like the mouse and keyboard do not utilize the full interaction potential -- especially regarding bimanual control -- of the human hand. The growing interest and the commercial breakthrough of multi-touch displays and interactive surfaces raises questions about their potential in the context of 3d modeling, which are thoroughly discussed and evaluated in this work. The presented approach is closely aligned to the whole processing chain for multi-touch applications, starting with the hardware and tracking issues, continuing with fundamental design discussions and operations like selection and 3D manipulation of objects and finishing with complex modeling techniques and metaphors. In regard to hardware and tracking, a robust illumination setup for the diffuse illumination technique is presented along with two extensions of this approach, i.e., hover detection and hand distinction. The design space is organized into specific design dimensions characterized by extremal positions to allow a better overview of design choices and a classification of existing and future systems. Fundamental techniques for selection and integrated 3D manipulation with six degrees of freedom are presented and empirically evaluated. Finally, two established modeling techniques -- implicit surfaces and virtual sculpting -- are extended and evaluated for multi-touch input

    3D-Modellierung mit interaktiven Oberflächen

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    3D models are at the core of many important applications from industry, science, and also entertainment. The creation of 3D models is a complex and time consuming process. Current modeling tools are hard to learn and require a deep understanding of the underlying mathematical models. Furthermore, established input devices like the mouse and keyboard do not utilize the full interaction potential -- especially regarding bimanual control -- of the human hand. The growing interest and the commercial breakthrough of multi-touch displays and interactive surfaces raises questions about their potential in the context of 3d modeling, which are thoroughly discussed and evaluated in this work. The presented approach is closely aligned to the whole processing chain for multi-touch applications, starting with the hardware and tracking issues, continuing with fundamental design discussions and operations like selection and 3D manipulation of objects and finishing with complex modeling techniques and metaphors. In regard to hardware and tracking, a robust illumination setup for the diffuse illumination technique is presented along with two extensions of this approach, i.e., hover detection and hand distinction. The design space is organized into specific design dimensions characterized by extremal positions to allow a better overview of design choices and a classification of existing and future systems. Fundamental techniques for selection and integrated 3D manipulation with six degrees of freedom are presented and empirically evaluated. Finally, two established modeling techniques -- implicit surfaces and virtual sculpting -- are extended and evaluated for multi-touch input

    Coordinating vector field equations and diagrams with a serious game in introductory physics

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    Mathematical reasoning with algebraic and graphical representations is essential for success in physics courses. Many problems require students to fluently move between algebraic and graphical representations. We developed a freely available serious game to challenge the representational fluency of introductory students regarding vector fields. Within the game, interactive puzzles are solved using different types of vector fields that must be configured with the correct mathematical parameters. A reward system implemented in the game prevents from using trial-and-error approaches and instead encourages the player to establish a mental connection between the graphical representation of the vector field and the (algebraic) equation before taking any action. For correct solutions, the player receives points and can unlock further levels. We report about the aim of the game from an educational perspective, describe potential learning scenarios and reflect about a first attempt to use the game in the classroom

    PKCδ Sensitizes Neuroblastoma Cells to L-Buthionine-Sulfoximine and Etoposide Inducing Reactive Oxygen Species Overproduction and DNA Damage

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    Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to chemotherapy and radiation is inhibited by the presence of antioxidants, such as glutathione (GSH), which is crucial in counteracting the endogenous production of reactive oxygen species (ROS). We have previously demonstrated that cells depleted of GSH undergo apoptosis via oxidative stress and Protein kinase C (PKC) δ activation. In the present study, we transfected PKCδ in NB cells resistant to oxidative death induced by L-buthionine-S,R-sulfoximine (BSO), a GSH-depleting agent. Cell responses, in terms of ROS production, apoptosis and DNA damage were evaluated. Moreover, PKCδ activation was monitored by analyzing the phosphorylation status of threonine 505 residue, carrying out PKC activity assay and investigating the subcellular localization of the kinase. The cell responses obtained in BSO-resistant cells were also compared with those obtained in BSO-sensitive cells subjected to the same experimental protocol. Our results demonstrate, for the first time, that PKCδ induces DNA oxidation and ROS overproduction leading to apoptosis of BSO-resistant NB cells and potentiates the cytotoxic effects induced by BSO in sensitive cells. Moreover, PKCδ overexpression enhances the sensitivity of NB cells to etoposide, a well-characterised drug, commonly used in neuroblastoma therapy. Altogether our data provide evidence of a pro-oxidant role of PKCδ that might be exploited to design new therapeutic strategies aimed at selective killing of cancer cells and overcoming drug resistance. However, it becomes evident that a more detailed understanding of ROS-mediated signaling in cancer cells is necessary for the development of redox-modulated therapeutic approaches

    3D Modeling with Interactive Surfaces

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    3D models are at the core of many important applications from industry, science, and also entertainment. The creation of 3D models is a complex and time consuming process. Current modeling tools are hard to learn and require a deep understanding of the underlying mathematical models. Furthermore, established input devices like the mouse and keyboard do not utilize the full interaction potential -- especially regarding bimanual control -- of the human hand. The growing interest and the commercial breakthrough of multi-touch displays and interactive surfaces raises questions about their potential in the context of 3d modeling, which are thoroughly discussed and evaluated in this work. The presented approach is closely aligned to the whole processing chain for multi-touch applications, starting with the hardware and tracking issues, continuing with fundamental design discussions and operations like selection and 3D manipulation of objects and finishing with complex modeling techniques and metaphors. In regard to hardware and tracking, a robust illumination setup for the diffuse illumination technique is presented along with two extensions of this approach, i.e., hover detection and hand distinction. The design space is organized into specific design dimensions characterized by extremal positions to allow a better overview of design choices and a classification of existing and future systems. Fundamental techniques for selection and integrated 3D manipulation with six degrees of freedom are presented and empirically evaluated. Finally, two established modeling techniques -- implicit surfaces and virtual sculpting -- are extended and evaluated for multi-touch input

    The Personal Reader: A Framework for Enabling Personalization Services on the Semantic Web

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    The Personal Reader provides a framework for designing, implementing and maintaining web content readers, which provide personalized enrichment of web content for each individual user

    Entertainment Computing - ICEC 2012: 11th International Conference, ICEC 2012, Bremen, Germany, September 26-29, 2012. Proceedings

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    International audienceBook Front Matter of LNCS 752
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