11 research outputs found
How Can Computer Science Help Cancer Survivors Children?
Survival
of
childhood
cancer
has
grown
thanks
to
more
effective
but
more
aggressive
treatments.
As
their
life
expectancy
has
increased,
they
have
discovered
important
long-‐term
side
effects
that
significantly
limit
their
quality
of
life:
cognitive,
linguistic,
physical,
and
social
effects.
The
most
significant
problems
are
related
to
language
and
communication,
which
prevent
the
child
from
expressing
himself
properly,
having
difficulty
finding
the
right
word.
This
poster
presents
some
possible
computer
mediated
solutions
to
improve
children
cancer
survivors’
quality
of
life
A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic \u27fat-free\u27 mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage with compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further distinguishes bone marrow from peripheral adipocytes and contributes to our understanding of bone marrow adipocyte origins, adaptations, and relationships with surrounding tissues with age and disease
¿Cómo puede la Informática ayudar a los niños supervivientes de cáncer?
La
supervivencia
al
cáncer
infantil
ha
crecido
gracias
a
tratamientos
más
efectivos,
aunque
más
agresivos.
A
medida
que
ha
aumentado
su
esperanza
de
vida,
se
han
descubierto
importantes
efectos
secundarios
a
largo
plazo
que
limitan
de
manera
significativa
su
calidad
de
vida:
efectos
cognitivos,
lingüísticos,
físicos,
sociales.
Los
problemas
más
significativos
están
relacionados
con
el
lenguaje
y
la
comunicación,
que
impiden
que
el
niño
pueda
expresarse
de
manera
apropiada,
teniendo
dificultades
para
encontrar
la
palabra
adecuada.
Este
póster
presenta
algunas
posibles
soluciones
basadas
en
tecnologías
TIC
para
mejorar
la
calidad
de
vida
de
los
sobrevivientes
de
cáncer
infantil
Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling
Bone marrow adipocytes resist lipolysis and remodeling in response to β-adrenergic stimulation
Bone Marrow Adipose Tissue: White, Brown or Beige?
From the Washington University Office of Undergraduate Research Digest (WUURD), Vol. 13, 05-01-2018. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College of Arts & Sciences; Lindsey Paunovich, Editor; Helen Human, Programs Manager and Assistant Dean in the College of Arts and Sciences Mentor(s): Erica L. Schellar and Clarissa S. Craf