Species competition: coexistence, exclusion and clustering

We present properties of Lotka-Volterra equations describing ecological competition among a large number of competing species. First we extend to the case of a non-homogeneous niche space stability conditions for solutions representing species coexistence. Second, we discuss mechanisms leading to species clustering and obtain an analytical solution for a lumped state in a specific instance of the system. We also discuss how realistic ecological interactions may result in different types of competition coefficients.Comment: 9 pages, 4 figures. Replaced with published version. Freely available from the publisher site under the Creative Commons Attribution licens

Human papillomavirus E2 regulates SRSF3 (SRp20) to promote capsid protein expression in infected differentiated keratinocytes

The human papillomavirus (HPV) life cycle is tightly linked to differentiation of the infected epithelial cell suggesting a sophisticated interplay between host cell metabolism and virus replication. Previously we demonstrated in differentiated keratinocytes in vitro and in vivo that HPV16 infection caused increased levels of the cellular SR splicing factors (SRSFs) SRSF1 (ASF/SF2), SRSF2 (SC35) and SRSF3 (SRp20). Moreover, the viral E2 transcription and replication factor that is expressed at high levels in differentiating keratinocytes could bind and control activity of the SRSF1 gene promoter. Here we reveal that E2 proteins of HPV16 and HPV31 control expression of SRSFs 1, 2 and 3 in a differentiation-dependent manner. E2 has the greatest trans-activation effect on expression of SRSF3. siRNA depletion experiments in two different models of the HPV16 life cycle (W12E and NIKS16) and one model of the HPV31 life cycle (CIN612-9E) revealed that only SRSF3 contributed significantly to regulation of late events in the virus life cycle. Increased levels of SRSF3 are required for L1 mRNA and capsid protein expression. Capsid protein expression was regulated specifically by SRSF3 and appeared independent of other SRSFs. Taken together these data suggest a significant role of the HPV E2 protein in regulating late events in the HPV life cycle through transcriptional regulation of SRSF3 expression. IMPORTANCE Human papillomavirus replication is accomplished in concert with differentiation of the infected epithelium. Virus capsid protein expression is confined to the upper epithelial layers so as to avoid immune detection. In this study we demonstrate that the viral E2 transcription factor activates the promoter of the cellular SRSF3 RNA processing factor. SRSF3 is required for expression of the E4̂L1 mRNA and so controls expression of the HPV L1 capsid protein. Thus we reveal a new dimension of virus-host interaction crucial for production of infectious virus. SRSF proteins are known drug targets. Therefore, this study provides an excellent basis for developing strategies to regulate capsid protein production in the infected epithelium and production of new virions

“ASOCIACION ENTRE SOBREPESO Y OBESIDAD CON COMPLICACIONES MATERNAS EN EL EMBARAZO Y PUERPERIO EN EL HOSPITAL GENERAL DE CUAUTITLAN “GENERAL JOSE VICENTE VILLADA” JULIO-DICIEMBRE 2016

4. RESUMEN La OMS clasifica la obesidad como una pandemia. La prevalencia de sobrepeso y obesidad es mayor en mujeres, representando un 63% de mujeres por grupo de edad, así como el 50% de las mujeres embarazadas presentan obesidad o sobrepeso. En mujeres gestantes el sobrepeso y la obesidad se han asociado a un mayor número de complicaciones durante el embarazo, como son la diabetes gestacional, la enfermedad hipertensiva del embarazo, la preeclampsia, las infecciones maternas (urinarias o endometritis) la enfermedad tromboembólica, el asma y la apnea del sueño. OBJETIVO: Conocer la asociación existente en pacientes con obesidad y sobrepeso con las complicaciones maternas en el embarazo y puerperio en el Hospital General de Cuautitlán “General José Vicente Villada” Se realizó un estudio: Descriptivo, Observacional, Retrospectivo, Transversal. Se analizaron expedientes, de las pacientes con obesidad y sobrepeso durante el embarazo, las cuales fueron captadas a su ingreso a la unidad toco quirúrgica de esta unidad, para analizar la evolución así como la resolución del embarazo en un periodo de 01 Julio 2016 al 31 de Diciembre 2016

The SU(3) spin chain sigma model and string theory

The ferromagnetic integrable SU(3) spin chain provides the one loop anomalous dimension of single trace operators involving the three complex scalars of N=4 supersymmetric Yang-Mills. We construct the non-linear sigma model describing the continuum limit of the SU(3) spin chain. We find that this sigma model corresponds to a string moving with large angular momentum in the five-sphere in AdS_5xS^5. The energy and spectrum of fluctuations for rotating circular strings with angular momenta along three orthogonal directions of the five-sphere is reproduced as a particular case from the spin chain sigma model.Comment: 14 pages. Latex.v2: Misprints corrected. v3: Minor changes and improved details from journal versio

Top marine predators track Lagrangian coherent structures

Meso- and submesoscales (fronts, eddies, filaments) in surface ocean flow have a crucial influence on marine ecosystems. Their dynamics partly control the foraging behaviour and the displacement of marine top predators (tuna, birds, turtles, and cetaceans). In this work we focus on the role of submesoscale structures in the Mozambique Channel on the distribution of a marine predator, the Great Frigatebird. Using a newly developed dynamical concept, namely the Finite-Size Lyapunov Exponent (FSLE), we have identified Lagrangian coherent structures (LCSs) present in the surface flow in the Channel over a 2-month observation period (August and September 2003). By comparing seabirds' satellite positions with LCSs locations, we demonstrate that frigatebirds track precisely these structures in the Mozambique Channel, providing the first evidence that a top predator is able to track these FSLE ridges to locate food patches. After comparing bird positions during long and short trips, and different parts of these trips, we propose several hypotheses to understand how frigatebirds can follow these LCSs. The birds might use visual and/or olfactory cues and/or atmospheric current changes over the structures to move along these biological corridors. The birds being often associated to tuna schools around foraging areas, a thorough comprehension of their foraging behaviour and movement during the breeding season is crucial not only to seabirds' ecology but also to an appropriate ecosystemic approach of fisheries in the Channel

The elementary excitations of the exactly solvable Russian doll BCS model of superconductivity

The recently proposed Russian doll BCS model provides a simple example of a many body system whose renormalization group analysis reveals the existence of limit cycles in the running coupling constants of the model. The model was first studied using RG, mean field and numerical methods showing the Russian doll scaling of the spectrum, E(n) ~ E0 exp(-l n}, where l is the RG period. In this paper we use the recently discovered exact solution of this model to study the low energy spectrum. We find that, in addition to the standard quasiparticles, the electrons can bind into Cooper pairs that are different from those forming the condensate and with higher energy. These excited Cooper pairs can be described by a quantum number Q which appears in the Bethe ansatz equation and has a RG interpretation.Comment: 36 pages, 12 figure

The nuclear receptor LXRα controls the functional specialization of splenic macrophages.

Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was essential for the differentiation of macrophages in the marginal zone (MZ) of the spleen. LXR-deficient mice were defective in the generation of MZ and metallophilic macrophages, which resulted in abnormal responses to blood-borne antigens. Myeloid-specific expression of LXRα or adoptive transfer of wild-type monocytes restored the MZ microenvironment in LXRα-deficient mice. Our results demonstrate that signaling via LXRα in myeloid cells is crucial for the generation of splenic MZ macrophages and identify an unprecedented role for a nuclear receptor in the generation of specialized macrophage subsets