GUÍA DE EVALUACIÓN DEL APRENDIZAJE MORFOLOGÍA VEGETAL

GUÍA DE EVALUACIÓN DEL APRENDIZAJ

Gonadal Development and Sexual Dimorphism of Gobiomorus dormitor from the Estuarine System of Tecolutla, Veracruz, Mexico

The bigmouth sleeper, Gobiomorus dormitor, is a benthic, euryhaline species, and is very abundant in river mouths, coastal lagoons, and sites away from marine influence from south Florida to Dutch Guyana. There are few studies of its life history, ecology, and abundance, particularly within Mexican waters. Nine trips to Tecolutla estuary, Veracruz, Mexico, were taken between October 1995 and May 1998 to estimate the gonadal development and sexual dimorphism of G. dormitor. A total of 94 individuals ranging from 15–260 mm SL and 0.05–181 g were captured. Seventy-two specimens were adults (60 females, 12 males) and 22 were juveniles that did not show external sexual dimorphism. Both juvenile and adult stages of G. dormitor were captured year-round in seagrass beds and adjacent shallow, muddy or sandy areas. This study has shown that G. dormitor are resident and undergo sexual maturation in the Tecolutla estuary. Histological evidence suggests both males and females undergo gonadal recrudescence in the estuary and have an extended reproductive season from May through November. However, it is unclear if the species actually spawns in the estuary, since females in the final stages of oocyte maturation were not captured. Additional research on the reproductive biology and ecology of this under-studied species is necessary to determine its role in tropical estuaries in the southern Gulf of Mexico. Information learned from areas in the center of its distribution may aid in conserving the species at the periphery of its range in Florida, where it is considered threatened

Variaciones climáticas en la Zona Metropolitana de la Ciudad de Toluca, Estado de México: 1960-2007

Los científicos del Panel Intergubernamental para el Cambio Climático (ipcc, 2001), han analizado las posibles consecuencias que pueden representar los cambios climáticos en distintos espacios geográficos de la Tierra. En México, el cambio climático empieza a ser notorio, por esta razón se realizó una investigación en la Zona Metropolitana de la Ciudad de Toluca y su hinterland para estudiar el comportamiento de la temperatura y la precipitación entre 1960 y 2007, y demostrar la existencia de variaciones que pueden contribuir al cambio climático. El sustento teórico de esta investigación fue la geografía ambiental, y el metodológico se basó en la estadística, trabajo de campo, el método comparativo y la cartografía automatizada. Con los resultados obtenidos se puede concluir que el clima en la zmct y su hinterland están en proceso de cambio y, de acuerdo con las investigaciones e informes de la nasa y el ipcc, éste seguirá cambiando globalmente.Los cientíÀcos del Panel Intergubernamental para el Cambio Climático (ipcc, 2001), han analizado las posibles consecuencias que pueden representar los cambios climáticos en distintos espacios geográÀcos de la Tierra. En México, el cambio climático empieza a ser notorio, por esta razón se realizó una investigación en la Zona Metropolitana de la Ciudad de Toluca y su hinterland para estudiar el comportamiento de la temperatura y la precipitación entre 1960 y 2007, y demostrar la existencia de variaciones que pueden contribuir al cambio climático. El sustento teórico de esta investigación fue la geografía ambiental, y el metodológico se basó en la estadística, trabajo de campo, el método comparativo y la cartografía automatizada. Con los resultados obtenidos se puede concluir que el clima en la zmct y su hinterland están en proceso de cambio y, de acuerdo con las investigaciones e informes de la nasa y el ipcc, éste seguirá cambiando globalmente

Trade-SCAN 1.1 – A Tool for Trade Supply Chain Analysis

This document consists in a User Manual of the tool Trade-SCAN 1.1, which has been developed by the European Commission's Joint Research Centre to help users understanding how international trade flows affect employment and income in the EU. In particular, TRADE-SCAN 1.1 allows calculating "value added in trade" type of indicators (also for employment by skills, gender, sectors, age groups…) on the spot and with ad-hoc queries specified by the user. The main data source is the World Input-Output Database (WIOD), 2016 release, complemented with data on employment by age, skill and gender from other sources such as EUKLEMS. The geographical breakdown of the data includes the 28 EU Member States, Australia, Brazil, Canada, China, India, Indonesia, Japan, Mexico, Norway, Russia, South Korea, Switzerland, Turkey, Taiwan, the United States, and an aggregate “Rest of the World” region. The industry breakdown consists of 56 sectors: agriculture and mining (4), manufacturing (22) and services (30).JRC.B.5-Circular Economy and Industrial Leadershi

Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial

INTRODUCTION: Extracorporeal circulation induces hemostatic alterations that lead to inflammatory response (IR) and postoperative bleeding. Tranexamic acid (TA) reduces fibrinolysis and blood loss after cardiopulmonary bypass (CPB). However, its effects on IR and vasoplegic shock (VS) are not well known and elucidating these effects was the main objective of this study. METHODS: A case control study was carried out to determine factors associated with IR after CPB. Patients undergoing elective CPB surgery were randomly assigned to receive 2 g of TA or placebo (0.9% saline) before and after intervention. We performed an intention-to-treat analysis, comparing the incidence of IR and VS. We also analyzed several biological parameters related to inflammation, coagulation, and fibrinolysis systems. We used SPSS version 12.2 for statistical purposes. RESULTS: In the case control study, 165 patients were studied, 20.6% fulfilled IR criteria, and the use of TA proved to be an independent protective variable (odds ratio 0.38, 95% confidence interval 0.18 to 0.81; P < 0.01). The clinical trial was interrupted. Fifty patients were randomly assigned to receive TA (24) or placebo (26). Incidence of IR was 17% in the TA group versus 42% in the placebo group (P = 0.047). In the TA group, we observed a significant reduction in the incidence of VS (P = 0.003), the use of norepinephrine (P = 0.029), and time on mechanical ventilation (P = 0.018). These patients showed significantly lower D-dimer, plasminogen activator inhibitor 1, and creatine-kinase levels and a trend toward lower levels of soluble tumor necrosis factor receptor and interleukin-6 within the first 24 hours after CPB. CONCLUSION: The use of TA attenuates the development of IR and VS after CPB. TRIAL REGISTRATION NUMBER: ISRCTN05718824

Fishing the targets of bioactive compounds from Psidium guajava L. leaves in the context of diabetes

Psidium guajava L. (guava) leaves have demonstrated their in vitro and in vivo effect against diabetes mellitus (DM). However, there is a lack of literature concerning the effect of the individual phenolic compounds present in the leaves in DM disease. The aim of the present work was to identify the individual compounds in Spanish guava leaves and their potential contribution to the observed anti-diabetic effect. Seventy-three phenolic compounds were identified from an 80% ethanol extract of guava leaves by high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry. The potential anti-diabetic activity of each compound was evaluated with the DIA-DB web server that uses a docking and molecular shape similarity approach. The DIA-DB web server revealed that aldose reductase was the target protein with heterogeneous affinity for compounds naringenin, avicularin, guaijaverin, quercetin, ellagic acid, morin, catechin and guavinoside C. Naringenin exhibited the highest number of interactions with target proteins dipeptidyl peptidase-4, hydroxysteroid 11-beta dehydrogenase 1, aldose reductase and peroxisome proliferator-activated receptor. Compounds catechin, quercetin and naringenin displayed similarities with the known antidiabetic drug tolrestat. In conclusion, the computational workflow showed that guava leaves contain several compounds acting in the DM mechanism by interacting with specific DM protein targets.The Spanish Ministry of Economy and Competitiveness; partially supported by the supercomputing infrastructure of Poznan Supercomputing Center, the e-infrastructure program of the Research Council of Norway, the supercomputer center of UiT—the Arctic University of Norway and by the computing facilities of Extremadura Research Centre for Advanced Technologies (CETA–CIEMAT), funded by the European Regional Development Fund (ERDF). This work was also supported by the Spanish Ministry of Economy and Competitiveness.https://www.mdpi.com/journal/ijmsBiochemistrySDG-03:Good heatlh and well-bein

Virtual research and learning communities in Latin America : The CEVALE2VE case

New strategies for the adaptation of higher scientific education to the requirements of the network society are briefly discussed, in particular the pivotal role played by virtual research and learning communities in the Latin American region. The Centro Virtual de Altos Estudios de Altas Energias (CEVALE2VE) is singled out in reference to the virtual graduate course on particle physics that was given at several Venezuelan and Colombian national universities and research institutions during the semesters September 2014 - February 2015 and March 2016 - July 2016. Different course implementation aspects are reviewed to encourage and facilitate similar regional initiatives in the near future.Peer reviewe

Surgical treatment for colorectal cancer: Analysis of the influence of an enhanced recovery programme on long-term oncological outcomes-a study protocol for a prospective, multicentre, observational cohort study

Introduction The evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life. Methods and analysis A multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant. Ethics and dissemination Ethical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings.The present research study was awarded a Ministerio de Ciencia e Innovación health research project grant (PI19/00291) from the Carlos III Institute of the Spanish National Health Service as part of the 2019 call for Strategic Action in Health

DIA-DB : a database and web server for the prediction of diabetes drugs

The DIA-DB is a web server for the prediction of diabetes drugs that uses two different and complementary approaches: (a) comparison by shape similarity against a curated database of approved antidiabetic drugs and experimental small molecules and (b) inverse virtual screening of the input molecules chosen by the users against a set of therapeutic protein targets identified as key elements in diabetes. As a proof of concept DIA-DB was successfully applied in an integral workflow for the identification of the antidiabetic chemical profile in a complex crude plant extract. To this end, we conducted the extraction and LC-MS based chemical profile analysis of Sclerocarya birrea and subsequently utilized this data as input for our server. The server is open to all users, registration is not necessary, and a detailed report with the results of the prediction is sent to the user by email once calculations are completed. This is a novel public domain database and web server specific for diabetes drugs and can be accessed online through http://bio-hpc.eu/software/dia-db/.http://pubs.acs.org/journal/jcics1/about.htmlhj2021BiochemistryGeneticsMicrobiology and Plant Patholog