Acute Colchicine-induced Neuromyopathy in a Patient Treated With Atorvastatin and Clarithromycin

Neuromyopathy is a rare side effect of chronic colchicine therapy, especially without renal impairment. Drugs interacting with colchicine metabolism through CYP3A4 can accelerate accumulation and toxicity. We describe a case of an interaction between atorvastatin, clarithromycin and colchicine resulting in acute neuromyopathy. Learning points: Colchicine has a narrow therapeutic window, and therefore, often produces side effects.Special caution should be adopted if patients with renal disease and concomitant medications are given colchicine.Before prescribing colchicine, the clinical history, including previous medications and conditions, should be carefully considered

How cyclical do cyclically-adjusted balances remain? An EU study

Observed budget balances are an imperfect indicator of the fiscal policy stance, because fluctuations in economic activity induce automatic changes in the balance, hence the use of cyclically-adjusted balances (CAB). However, this paper shows that CABs (as measured through one of the two methods currently used by the Commission) tend to be systematically overestimated during downturns and underestimated during expansions. The dominant source of this distortion arises from the filtering of revenues deemed to be cyclical, possibly signalling a problem with the computation of elasticities. The effect of the items which are assumed not to move with the cycle is non significant, but this overall result conceals offseting effects: public investment turns to be significantly procyclical and interest payments and transfers to firms are countercyclical. Classification-JEL : H6, E6.. cyclically adjusted balances, fiscal policy, EU.

Annotation scheme for citation classification in scientific literature

El análisis de citas bibliográficas que usa variaciones de métodos de conteo provoca deformaciones en la evaluación del impacto. Para enriquecer el cálculo de los factores de impacto se necesita entender el tipo de influencia de los aportes de un investigador sobre el autor que los menciona. Para ello, se requiere realizar análisis de contenido del contexto de las citas que permita obtener su función, polaridad e influencia. El presente artículo trata sobre la definición de un esquema de anotación tendiente a la creación de un corpus de acceso público que sea la base de trabajo colaborativo en este campo, con miras al desarrollo de sistemas que permitan llevar adelante tareas de análisis de contenido con el objetivo planteado.Citation analysis that uses counting methods causes deformations in impact factor assessment. To enrich impact factor calculation is necessary to understand the kind of influence that the contributions of an author have over another´s work. For this purpose, it is required to perform citation content analysis to obtain its function, polarity and influence in a context within an article that mentioned it. In this paper, we focus in the definition of an annotation scheme aimed at creating a public access corpus that be the basis of collaborative work in this field, in order to develop citation content analysis to obtain criteria for impact evaluation

Propagation of time-truncated Airy-type pulses in media with quadratic and cubic dispersion

In this paper, we describe analytically the propagation of Airy-type pulses truncated by a finite-time aperture when second and third order dispersion effects are considered. The mathematical method presented here, based on the superposition of exponentially truncated Airy pulses, is very effective, allowing us to avoid the use of time-consuming numerical simulations. We analyze the behavior of the time truncated Ideal-Airy pulse and also the interesting case of a time truncated Airy pulse with a "defect" in its initial profile, which reveals the self-healing property of this kind of pulse solution.Comment: 9 pages. 5 figure

How to distinguish between a block cipher and a random permutation by lowering the input entropy

IEEE 35th International Carnahan Conference on Security Technology. Londres, 16-19 October 2001A novel cryptanalysis technique is presented, and its suitability for distinguishing a block cipher algorithm or a hash function from a random permutation is explained. Additionally, we propose a genetic algorithm based implementation and show some preliminary results of these ideas on reduced rounds versions of the block cipher TEA