Efecto de las crisis repetitivas en el modelo experimental de epilepsia GASH: Sal

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Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden

Actas del Congreso Internacional sobre Epilepsia Audiógena: de los modelos a la clínica.

El libro del primer congreso internacional “Epilepsia Audiógena: de los modelos a la clínica” contiene las presentaciones y contribuciones realizadas por los investigadores en la conferencia. El congreso se celebró en Salamanca del 9 al 12 de Septiembre de 2014. La sede del congreso es el Instituto de Neurociencias de Castilla y León (INCyL), un centro dedicado a la investigación científica en el sistema nervioso y sus patologías así como a la formación de nuevos investigadores y a la divulgación científica. El congreso tuvo un programa científico de excelencia, diverso y compacto centrado en los modelos experimentales de epilepsias reflejas y su relación con la clínica. Los participantes tuvieron la oportunidad de disfrutar de conferenciantes invitados de reconocido prestigio mundial en el campo de la epilepsia. De especial interés fueron los principales temas tratados durante el congreso: epilepsia refleja, modelos de epilepsia audiógena, modelos genéticos de epilepsia, fármacos antiepilépticos y epilepsias humanas.The programme book of the the First International Conference “Audiogenic Epilepsy: from Animal Models to the Clinic” contains the proceedings and contributions made by researchers at the conference. The Congress was held at the Neuroscience Institute of Castilla y León (INCyL), Salamanca, Spain, from September 9th – 12th, 2014 and focused on a broad spectrum of cutting-edge epilepsy research and technologies. During the conference, we had the opportunity to enjoy with excellent and internationally well-recognized keynote speakers. This Congress was intended to be a consolidated forum for multidisciplinary interaction between basic research and clinical scientists, working at the genetic-molecular, cellular, and behaviour levels. Of special interest were the main topics of the Congress: reflex epilepsies, audiogenic seizure models, genetic models of epilepsy, antiepileptic drugs, and human epilepsiesFundación Ramón Areces, Fundación Alicia Koplowitz, Esteve Veterinaria, Instituto de Biomedicina de Salamanca (IBSAL), Univeridad de Salamanca, Instituto de Neurociencias de Castilla y León (INCYL), Charles River, Fotocopias Idem, Microsercon, Ayuntamiento de Salamanc