Velocity-changing collisional effects in nonlinear atomic spectroscopy and photon echo decay in gases

A general theory of atomic dipole coherence under the influence of collisional phase changes, inelastic effects and optically active atom velocity changes, including those due to anisotropic interactions is presented. Velocity change effects are obtained in closed form. Line shapes appear as convolutions of standard pressure broadening contours with velocity-change contours. Width and shift parameters for the He-broadened Na D lines at 2 m bar pressure, 380 K are calculated, as are He-induced photon echo decay rates for these lines. Overall agreement with xperiment is reasonably good

Total destruction of invariant tori for the generalized Frenkel-Kontorova model

We consider generalized Frenkel-Kontorova models on higher dimensional lattices. We show that the invariant tori which are parameterized by continuous hull functions can be destroyed by small perturbations in the $C^r$ topology with $r<1$

Drug Management Reviews in District Drug Management Unit and General Hospital

Drug is one of the essential elements in healthcare that should be effectively and efficiently managed. Following the decentralization in 2001 in Indonesia, drug management has changed in district drug management units and also in District General Hospitals. Certainly this condition influences the sustainability of drug access in primary health care such as in Community Health Center and District General Hospital, especially in drug financing policy. A cross sectional descriptive study to obtain information on drug management in public healthcare in district had been carried out between July and December 2006 in 10 District Public Drug Management Units from 10 district health offices and 9 district general hospitals as samples. Data were collected by interviewing heads of Drug Section in District Health Offices and heads of Hospital Pharmacies using structured questionnaires and observing drug storage in District Drug Management Units, Community Health Centers, and Hospital Pharmacies. Results of the study show that drug planning in District Health Offices and General Hospitals did not meet the basic real need in some districts nor District Hospitals. The minimum health service standards had not been achieved yet. Furthermore, drug procurement, storage and recording as well as reporting was not good enough either, such as shown by the existence of expired drugs. Lead time for drug delivery to community health centers in some districts was longer than the average of lead time in the past 3 years

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential

Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects on HSCs. Single-cell analysis of Cxcl12-abundant reticular (CAR) cells and PDGFRα+Sca1+ (PαS) cells revealed an extensive cellular heterogeneity but uniform expression of the transcription factor gene Ebf1. Conditional deletion of Ebf1 in these MSCs altered their cellular composition, chromatin structure and gene expression profiles, including the reduced expression of adhesion-related genes. Functionally, the stromal-specific Ebf1 inactivation results in impaired adhesion of HSCs, leading to reduced quiescence and diminished myeloid output. Most notably, HSCs residing in the Ebf1-deficient niche underwent changes in their cellular composition and chromatin structure that persist in serial transplantations. Thus, genetic alterations in the BM niche lead to long-term functional changes of HSCs

Boundaries of Siegel Disks: Numerical Studies of their Dynamics and Regularity

Siegel disks are domains around fixed points of holomorphic maps in which the maps are locally linearizable (i.e., become a rotation under an appropriate change of coordinates which is analytic in a neighborhood of the origin). The dynamical behavior of the iterates of the map on the boundary of the Siegel disk exhibits strong scaling properties which have been intensively studied in the physical and mathematical literature. In the cases we study, the boundary of the Siegel disk is a Jordan curve containing a critical point of the map (we consider critical maps of different orders), and there exists a natural parametrization which transforms the dynamics on the boundary into a rotation. We compute numerically this parameterization and use methods of harmonic analysis to compute the global Holder regularity of the parametrization for different maps and rotation numbers. We obtain that the regularity of the boundaries and the scaling exponents are universal numbers in the sense of renormalization theory (i.e., they do not depend on the map when the map ranges in an open set), and only depend on the order of the critical point of the map in the boundary of the Siegel disk and the tail of the continued function expansion of the rotation number. We also discuss some possible relations between the regularity of the parametrization of the boundaries and the corresponding scaling exponents. (C) 2008 American Institute of Physics.NSFMathematic

Forebrain Origins of Glutamatergic Innervation to the Rat Paraventricular Nucleus of the Hypothalamus: Differential Inputs to the Anterior Versus Posterior Subregions

The hypothalamic paraventricular nucleus (PVN) regulates numerous homeostatic systems and functions largely under the influence of forebrain inputs. Glutamate is a major neurotransmitter in forebrain, and glutamate neurosignaling in the PVN is known to mediate many of its functions. Previous work showed that vesicular glutamate transporters (VGluTs; specific markers for glutamatergic neurons) are expressed in forebrain sites that project to the PVN; however, the extent of this presumed glutamatergic innervation to the PVN is not clear. In the present study retrograde FluoroGold (FG) labeling of PVN-projecting neurons was combined with in situ hybridization for VGluT1 and VGluT2 mRNAs to identify forebrain regions that provide glutamatergic innervation to the PVN and its immediate surround in rats, with special consideration for the sources to the anterior versus posterior PVN. VGluT1 mRNA colocalization with retrogradely labeled FG neurons was sparse. VGluT2 mRNA colocalization with FG neurons was most abundant in the ventromedial hypothalamus after anterior PVN FG injections, and in the lateral, posterior, dorsomedial, and ventromedial hypothalamic nuclei after posterior PVN injections. Anterograde tract tracing combined with VGluT2 immunolabeling showed that 1) ventromedial nucleus-derived glutamatergic inputs occur in both the anterior and posterior PVN; 2) posterior nucleus-derived glutamatergic inputs occur predominantly in the posterior PVN; and 3) medial preoptic nucleus-derived inputs to the PVN are not glutamatergic, thereby corroborating the innervation pattern seen with retrograde tracing. The results suggest that PVN subregions are influenced by varying amounts and sources of forebrain glutamatergic regulation, consistent with functional differentiation of glutamate projections. J. Comp. Neurol. 519:1301–1319, 2011. © 2010 Wiley-Liss, Inc

Infinite index extensions of local nets and defects

Subfactor theory provides a tool to analyze and construct extensions of Quantum Field Theories, once the latter are formulated as local nets of von Neumann algebras. We generalize some of the results of [LR95] to the case of extensions with infinite Jones index. This case naturally arises in physics, the canonical examples are given by global gauge theories with respect to a compact (non-finite) group of internal symmetries. Building on the works of Izumi, Longo, Popa [ILP98] and Fidaleo, Isola [FI99], we consider generalized Q-systems (of intertwiners) for a semidiscrete inclusion of properly infinite von Neumann algebras, which generalize ordinary Q-systems introduced by Longo [Lon94] to the infinite index case. We characterize inclusions which admit generalized Q-systems of intertwiners and define a braided product among the latter, hence we construct examples of QFTs with defects (phase boundaries) of infinite index, extending the family of boundaries in the grasp of [BKLR16].Comment: 50 page